Liverpool secured a dominant win over West Ham, while other Premier League matches saw Brentford edge Burnley in a seven-goal thriller and Everton secure a late victory against Newcastle.
Eberechi Eze timed his return to the Arsenal scoresheet to perfection with two goals in a 4-1 derby rout of Tottenham Hotspur.
Man City snatch chaotic 2-1 win at Liverpool to stay on Arsenal's heels
Images from the EPL matches played on Saturday.
Arsenal took a seven-point lead at the top of the Premier League after a scoreless draw with Nottingham Forest on Saturday.
Arsenal missed the chance to go eight points clear at the top of the Premier League in a turgid 0-0 draw with champions Liverpool.
Chelsea battled from two goals down to beat West Ham 3-2 in the Premier League on Saturday with a stoppage-time Enzo Fernandez winner.
Liverpool manager Arne Slot must find a way to arrest the team's slide even as the pressure mounts on him, former skipper Steven Gerrard said.
IMAGES from the Premier League matches played on Sunday
Liverpool striker Alexander Isak is expected to be sidelined for at least a couple of months after breaking his leg and undergoing surgery.
The Egypt forward has been left out of the club's Champions League match against Inter Milan.
Second-placed City would have reduced Arsenal's advantage to two points but instead were frustrated as their winning streak in all competitions was halted at eight.
Manchester City were drawn against Real Madrid in the Champions League knockout phase for the sixth time since the 2019-20 season after the draw for the last 16, quarterfinals and semifinals was made on Friday.
Liverpool forward Mohamed Salah is destroying his legacy at the club with his fiery reaction to being left out of the side, former Manchester United striker Wayne Rooney said.
Benjamin Sesko came off the bench to score the winner as Manchester United beat Everton 1-0 in the Premier League, strengthening their hold on fourth place under Michael Carrick.
Arne Slot planned to have a face-to-face meeting with Mohamed Salah on Friday ahead of Saturday's Premier League match against Brighton & Hove Albion.
City, Liverpool all cruise in respective FA Cup matches played on Saturday.
James Milner sets a new Premier League record with his 654th appearance as Brighton beat Brentford 2-0, surpassing Gareth Barry's mark.
Liverpool could be 14th in the table by the time they kick off at West Ham on Sunday afternoon and they will be desperate to steady the ship with three points.
Liverpool shrugged off the absence of Mohamed Salah as midfielder Dominik Szoboszlai scored an 88th-minute penalty to give them a 1-0 Champions League win at Inter Milan.
Goals from Pedro Neto and Enzo Fernandez earned Chelsea a 2-0 victory at lowly Burnley on Saturday, a win that moved the Blues within three points of Premier League leaders Arsenal.
Arsenal missed a chance to tighten their grip on the Premier League title race with a 1-1 draw at 10-man Chelsea on Sunday.
Manchester City halved Arsenal's lead at the top of the Premier League to three points with a 3-0 win over visitors Fulham, while Aston Villa stayed in the frame with a late 1-0 victory at home to Brighton & Hove Albion on Wednesday.
Second-string Liverpool were thumped 3-0 by Crystal Palace as Ismaila Sarr struck twice for the visitors in the League Cup on Wednesday, booking the London side's spot in the quarter-finals and piling more misery on Arne Slot's struggling side.
While his overall win rate is more than 70%, Liverpool have been a tough nut for Pep Guardiola to crack since he arrived at City in 2016, first under Juergen Klopp and now Arne Slot.
Dramatic night in the Champions League playoffs as goals, shocks and dominant performances decided the final places in the last 16.
Galatasaray struck twice in extra time to end 10-man Juventus' brave fightback and reach the Champions League's last 16, progressing with a 7-5 aggregate victory.
Aston Villa and Chelsea drop crucial points in the Premier League as Leeds and Burnley earn draws; James Milner sets appearance record.
A summary of Wednesday's action in the UEFA Champions League.
Arsenal extends its lead in the Premier League, while Manchester United strengthens its top-four bid. Chelsea's Cole Palmer shines with a hat-trick, and West Ham earns a crucial win in their fight against relegation.
Liverpool coach Arne Slot said he was delighted to have Mohamed Salah returning from Africa Cup of Nations duty soon, despite an apparent falling-out just weeks ago.
Arsenal's Premier League lead is cut to four points after a 1-1 draw against Brentford, with goals from Noni Madueke and Keane Lewis-Potter.
Manchester United's Harry Maguire struck a late header to seal a thrilling 2-1 Premier League victory over Liverpool on Sunday
Real Madrid are football's biggest earners, Liverpool best in Premier League
Bayern Munich made it 16 wins from 16 games this season to underline their credentials as early Champions League favourites, beating holders Paris St Germain 2-1 away as Luis Diaz scored two goals and was shown a red card on Tuesday.
England winger Raheem Sterling has left Chelsea by mutual agreement after being frozen out under successive managers, bringing an end to his troubled two-year spell at Stamford Bridge.
Manchester City set up a League Cup final date with Arsenal after a comprehensive 3-1 second-leg victory over visiting Newcastle United secured a 5-1 aggregate win in their semi-final.
Man City ease to 3-0 win over Liverpool as Guardiola celebrates 1,000th game in style
Premier League leaders Arsenal ended their mini-slump with an emphatic 4-0 victory at Leeds United on Saturday to move seven points clear despite Bukayo Saka being ruled out through injury just before kickoff.
IMAGES from UEFA Champions League matches played on Wednesday