Brighton secured their second victory of the competition with a comfortable win at Ajax thanks to goals from Ansu Fati and Simon Adingra.
Salah's sublime second-half strike leaves Liverpool on 67 points, three ahead of second-placed Arsenal and four ahead of City on a pivotal day in the title race.
Manchester City and Chelsea both secured their Champions League places with victories on the final day of the English Premier League season and Newcastle United joined them despite stumbling to a last-day defeat.
n own goal by Jakub Kiwior and a thumping late strike by Luis Diaz sealed a 2-0 victory for Liverpool at Arsenal
'It is that I am, how can I say it, running out of energy.'
Images from the Champions League semi-final first leg between Arsenal and Paris St Germain at Emirates Stadium, London, on Tuesday.
Liverpool's slim Premier League title hopes faded further on Saturday when Michail Antonio's late header earned West Ham United a deserved point with a 2-2 draw.
Liverpool kicked off the new year three points clear atop the English Premier League standings with a 4-2 victory over Newcastle United.
Arsenal, who trail Premier League leaders Liverpool by 12 points with nine games remaining, host Real Madrid in the first leg of their Champions League quarter-final next week.
Bukayo Saka scored either side of halftime as Arsenal crushed second-bottom Burnley 5-0.
Jose Mourinho's side top Group G with a maximum nine points, three clear of second-placed Slavia.
Arsenal defeated London rivals Chelsea 1-0 for their first win in four Premier League games on Sunday as a headed goal by stand-in striker Mikel Merino boosted their faint hopes of catching up with runaway leaders Liverpool.
A summary of Sunday's action in the Premier League.
'I want to make as big of an impression as I can and then just try and make the next camp. But obviously, every little kid's dream is to play in a World Cup.'
'The boys will be pleased not to lose but also definitely not happy we didn't win.'
Eddie Howe's side were ruthless in boosting their Champions League qualification hopes while 19th-placed Leicester became the first side in English Football League history to suffer eight successive home league defeats without scoring.
Liverpool reclaimed top spot in the Premier League with a 3-1 win over Burnley at Anfield on Saturday, but they were made to battle hard by a brave visiting side.
Champions Manchester City struggled in this campaign and sit sixth in the table after winning only two of their last 10 league matches.
IMAGES from the English Premier League matches played on Saturday.
Brazilian Casemiro struck late to send Manchester United into the FA Cup quarter-finals with a 1-0 victory over Nottingham Forest as teenagers Jayden Danns and Lewis Koumas inspired Liverpool to a 3-0 win over Southampton on Wednesday.
Aston Villa striker Marcus Rashford scored twice in a 3-0 defeat of second-tier Preston North End in their FA Cup quarter-final at Deepdale on Sunday to earn a Wembley semi-final against fellow Premier League team Crystal Palace.
Manchester City came from behind to beat Club Brugge 3-1 and secure their place in the Champions League playoffs
Liverpool cruised into the fifth round of the FA Cup with a 5-2 rout of Championship side Norwich City on Sunday, to kick off Juergen Klopp's long goodbye at Anfield.
Arsenal snapped a season-long jinx against Newcastle United with a nervy 1-0 win in their last Premier League home game on Sunday.
Van Dijk was sent off for fouling Alexander Isak during the first half and appeared to remonstrate with referee John Brooks before walking off the pitch.
With a game in hand, Hansi Flick's Barca are top on 66 points, three ahead Real in second
Liverpool moved back to the top of the Premier League with a 2-0 victory at struggling Burnley
Third-placed Aston Villa are the surprise package of the season and Unai Emery's side face relegation-threatened Burnley while fifth-placed Spurs host a resurgent Bournemouth who have 19 points from their last seven games.
Liverpool snatched three points with a wild 1-0 victory over relegation-threatened Nottingham Forest.
Athletic Bilbao beat Barcelona 4-2 at home to knock them out of the Copa del Rey
England debutant Myles Lewis-Skelly got new coach Thomas Tuchel's reign up and running as the 18-year-old scored the first goal in a 2-0 home victory against Albania in their World Cup qualifying Group K opener on Friday.
Arsenal closed the gap on leaders Liverpool with a 2-1 Premier League victory at Nottingham Forest
Jarrod Bowen and Mohammed Kudus' second-half goals gave West Ham a 2-0 win over Manchester United in the Premier League's early game on Saturday, as the Hammers briefly moved into the top six.
Manchester City and Arsenal closed in on Premier League leaders Liverpool with contrasting victories on Saturday as Manchester United's bubble was burst by Fulham.
A summary of Wednesday's Champions League first leg quarter-finals between Barcelona and Dortmund and Real Madrid, and Paris St Germain and Aston Villa.
Brazil, who are fifth in the CONMEBOL table with 18 points from 12 games, host Colombia on March 21 and visit Argentina five days later in a match that could see Neymar come up against former Barcelona and Paris St Germain teammate Lionel Messi.
Arsenal moved to 50 points from 24 games.
Koopmeiners leads Atalanta past Milan into Coppa semis
Graham Potter is in talks to replace Lopetegui, according to British media reports, and the former Chelsea and Brighton & Hove Albion manager is expected to take charge of West Ham for their FA Cup third-round game at Aston Villa on Friday.
West Ham beat Premier League strugglers Leicester City 2-0 at the London Stadium on Thursday thanks to an early strike from Tomas Soucek on his 30th birthday and an own goal just before halftime.