Barcelona came within a whisker of an improbable comeback after last month's thrashing, with 18-year-old midfielder Marc Bernal, starting in place of the injured Frenkie De Jong, scoring in each half and Raphinha converting a penalty after Pedri was fouled.
The winners of the tie will face Real Sociedad or Athletic Bilbao in the final. Real Sociedad hold a 1-0 advantage ahead of their second leg in San Sebastian on March 4.
Real Madrid booked a Spanish Super Cup final against Barcelona after beating city rivals Atletico Madrid 2-1 on Thursday.
Mario Lemina's early diving header handed Galatasaray a 1-0 victory over Liverpool in their Champions League last-16 first leg on Tuesday.
Bodo/Glimt secured an upset 3-1 victory over Serie A leaders Inter Milan in the first leg of their Champions League playoff on Wednesday.
Barcelona secured a composed 2-0 LaLiga victory at Villarreal on Sunday thanks to goals from Raphinha and Lamine Yamal in a match that tilted firmly in the visitors' favour when the hosts were reduced to 10 men just before the break.
Virgil van Dijk scored with a stunning late header in the second minute of stoppage time to give Liverpool a 3-2 victory over Atletico Madrid in their opening group stage match of the Champions League, at Anfield, on Wednesday.
IMAGES from football matches played across European Leagues on Saturday.
Atletico Madrid clawed back from two goals down to rescue a last-gasp 4-4 draw at Barcelona in a rip-roaring battle in the first leg of their Copa del Rey semi-final on Tuesday.
A summary of Monday's action in LaLiga and Serie A.
A summary of Saturday's action in Ligue 1, LaLiga and Bundesliga.
A summary of Wednesday's Champions League Round of 16, Second Leg, matches.
Barcelona top the LaLiga standings with 15 points, four ahead of Real Madrid and Villarreal. Girona are seventh on seven points.
Spain manager Luis de la Fuente left Barcelona's 17-year-old defender Pau Cubarsi and midfielders Marcos Llorente and Aleix Garcia out of his 26-man squad
All the action from La Liga and Serie A matches played on Monday
Manchester City squandered a three-goal lead to draw 3-3 with Feyenoord in the Champions League on Tuesday.
Second-half strikes by Federico Valverde, Brahim Diaz and Endrick gave feeble Real Madrid an unconvincing 3-0 win over lowly Real Valladolid.
Manchester City have one just victory from their last 10 games across all competitions.
Barcelona made a disappointing start to their Champions League campaign by losing 2-1 to AS Monaco on Thursday.
Girona reclaimed top spot in LaLiga after beating champions Barcelona 4-2
IMAGES from the UEFA Champions League last 16 matches played on Tuesday
The machine will replace hyperbaric oxygen chambers which the team have stopped using since Sergio Busquets tested positive for COVID-19 this month.
Photos from soccer matches played across top European Leagues on Saturday.
'It wasn't easy, but I called him last night (Sunday) and we had a difficult and tough conversation. I feel bad as he's a player who has always been at the top level and has a future with the national team.'
Alvaro Morata spurned Spain's best opportunity in a dominant first half display from Luis Enrique's side on a scorching evening at Seville's La Cartuja stadium in Group E when he missed the target from inside the area after a defensive slip.
Spain are still favourites to finish top of Group E above Sweden, Poland and Slovakia but, after struggling to break down conservative sides such as Georgia and Greece in March, they know coming first will not be a procession.
Milan missed the chance to jump to second and remained fourth with 48 points
IMAGES from the Champions League matches played on Tuesday.
The game, postponed from the start of the season, offered Atletico the chance to peel further away from nearest challengers Real Madrid but a second draw in three games only moved them on to 55 points.
An early goal from Pablo Sarabia earned Spain a 1-0 win in Switzerland on Thursday, their first victory of this year's UEFA Nations League.
United were unable to create enough quality opportunities to get themselves the goal they needed.
Manchester City took a slender lead from the first leg of their Champions League quarter-final after Kevin De Bruyne's 70th minute goal earned them a 1-0 win over Atletico Madrid at the Etihad Stadium on Tuesday. In anothr match, Liverpool took a firm grip of their Champions League tie with Benfica as goals from Ibrahima Konate, Sadio Mane and Luis Diaz earned them a 3-1 victory in Lisbon.
A summary of Saturday's action in the UEFA Nations League.
'This is very special because of how much I suffered. My statistics show I've won five league titles in seven years.'
Mbappe becomes PSG's all-time highest goal-scorer as French champions extend lead
The French forward, who joined the club in 2009, netted twice in the first-half to take his Real tally to 209 goals in 446 games, moving ahead of Mexican Hugo Sanchez into sixth place on the club's all-time top scorers list.
There were a few nerves at the end but Liverpool set up a Champions League semi-final with Spain's Villarreal after Roberto Firmino scored twice in a 3-3 second-leg draw with Benfica on Wednesday to ensure a 6-4 aggregate win.
Barcelona gave up more ground to Real Madrid in La Liga's title race on Tuesday after being held to a 2-2 draw at home to third-placed Atletico Madrid as a late penalty from Saul Niguez cancelled out Lionel Messi's 700th career goal. The draw meant the Catalans stayed second in the standings on 70 points and leaders Real Madrid, who have 71, will go four points clear at the top with five games left if they beat Getafe at home on Thursday.
After an almighty push by all parties concerned, Spain's La Liga roars back into action next week after a three-month pause due to the COVID-19 pandemic, with matches taking place every day and with everything to play for. The season resumes on Wednesday in bizarre circumstances with the second half of a Segunda Division match between Rayo Vallecano and Albacete that was abandoned in December due to offensive chanting.