Set 183 for victory, Andrew Balbirnie produced a stunning knock to take Ireland over the line with five wickets and a ball to spare in front of a sell-out crowd.
Jacob Bethell has represented England in 29 matches across all formats and will lead the team in the absence of the regular Test players.
Brydon Carse will replace Gus Atkinson for England's second T20 International against India on Saturday.
Hazlewood was initially named in the squad for South Africa, will also return home following the Test series. Xavier Bartlett has been drafted in as his replacement.
Tickets for Sydney ODI, Canberra T20I of India's white-ball tour of Australia sold out: CA
Gill will try to prove a point with aggressive cricket in Asia Cup, says Irfan Pathan
The second T20 will be played on Tuesday.
Samson reminded everyone of his class with a 54 off 36 balls in a high-voltage friendly at Greenfield Stadium, guiding the KCA Secretary XI to a nail-biting win ahead of the Kerala Cricket League.
Sunil Gavaskar said it's time to support India's Asia Cup squad, refusing to debate Yashasvi Jaiswal's exclusion.
Deepti Sharma credits long training period ahead of England tour for positive results
Shiv Sena (UBT) leader Aaditya Thackeray targeted the BCCI over India Pakistan cricket matches in the Asia Cup
The two marquee India versus Pakistan games will be held in Dubai during the upcoming Asia Cup which is scheduled to start in the UAE from September 9, the ACC announced on Saturday.
Meanwhile, England fast bowler Lauren Bell moved up two places to reach fourth in the rankings for bowlers after her three-wicket haul in the first T20I against India.
Dewald Brevis smashed his maiden T20 International century to power South Africa to an emphatic 53-run victory against Australia in the second T20I.
Mithali Raj feels India can end their long-standing trophy drought if they seize key moments
As Jasprit Bumrah prepares for his return to the shortest format in national colours in the upcoming Asia Cup 2025, scheduled from September 9 to 28 in the UAE, former Sri Lanka all-rounder Farveez Maharoof shared his thoughts on the pacer's recurring fitness issues and how the team management could effectively manage his workload.
The result extends a difficult run for the West Indies, who were coming off a clean sweep of defeats across formats against Australia earlier in the week.
Admirer of Tendulkar, inspired by Pandya, UAE's Alishan Sharafu ready for India challenge in Asia Cup
Both teams will now travel to the Caribbean for a three-match one-day international series.
As India's pace spearhead Jasprit Bumrah's workload management has become a topic of debate, former Team India opener Akash Chopra defended the pacer's selective participation in the longest format.
Pakistan head coach Mike Hesson said Babar Azam has been asked to improve certain aspects of his game.
India eye maiden women's T20I series win over England; hosts to miss injured skipper Brunt
Hardik Pandya rose two places to become the first Indian to occupy the No 1 spot in the ICC's T20I all-rounders' rankings.
Tilak Varma stole the show with a spectacular maiden century as India clinched a narrow 11-run win over South Africa in a high-scoring third T20 International.
He became the first player to record 100 wins in the shortest format of the game.
Uncapped left-arm seamer Ben Lister is likely to make his debut in the 2nd Test
West Indies all-rounder Russell set to retire from international cricket
Twice in two games, cricketing upstarts USA stunned Bangladesh again
Glenn Maxwell believes his spin bowling could come in handy in the Powerplay during next year's T20 World Cup to be held in India and Sri Lanka.
'As much as we may want, unka number itni aasani se nahi aayega (It's not going to be easy for Rahul)'
Shubman Gill and Jasprit Bumrah returned to India's T20 squad for next month's Asia Cup, but IPL star performers Shreyas Iyer and Yashasvi Jaiswal missed out.
Swashbuckling wicketkeeper-batter Ishan Kishan turns 27 on Friday!
All-rounder Holder returned figures of 4-19, surpassing Dwayne Bravo as the highest wicket-taker for West Indies in T20Is and then hit the winning runs under pressure, lifting West Indies to their first T20 victory in seven matches.
'We spoke about taking time and enjoying our batting but it didn't pan out that way.'
Women's cricket team gets rousing welcome at India House in London
Pakistan coach Mike Hesson slams Shere Bangla pitch after T20I loss; Bangladesh disagree
Zimbabwe secured victory off the last ball as they beat Afghanistan by four wickets in the first of their three-match Twenty20 series at the Harare Sports Club on Wednesday.
'If you consider Parag for captaincy, how do you expect Samson to stay?'
Shubman Gill dominated with the bat in England, as he amassed a huge tally of 567 runs at an average of 94.50 in the three Tests played in July.
Sophie Ecclestone returns as England announce squad for T20Is against India
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