Real Madrid forward Rodrygo will miss the rest of the season and the World Cup after tearing his ACL and outer meniscus in a LaLiga defeat against Getafe, the club confirmed.
Getafe secured a surprising 1-0 victory against Real Madrid in LaLiga, courtesy of Martin Satriano's stunning volley, leaving Barcelona with a four-point lead at the top of the table.
Benfica will also be without head coach Jose Mourinho, who is suspended after receiving a red card in the first leg.
Real Madrid booked a Spanish Super Cup final against Barcelona after beating city rivals Atletico Madrid 2-1 on Thursday.
Real Madrid now have 45 points from 19 matches, second behind defending champions Barcelona.
For Mourinho, it was an emotional night at the Estadio da Luz, capped by an extraordinary 98th-minute header from Trubin that ensured Benfica snatched a last-16 spot on goal difference.
IMAGES from the UEFA Champions League matches played on Wednesday.
'We've hit rock bottom; we've been knocked out by a second division team.'
Nico O'Reilly's opportunistic strike and Erling Haaland's penalty helped Manchester City to fight back to beat Real Madrid 2-1 in a tense Champions League contest at the Santiago Bernabeu on Wednesday.
Inter edge Genoa to go top
Estevao and Rodrygo at the double as Brazil thrash South Korea 5-0
Brazil beat Senegal 2-0 in feisty friendly at the Emirates
Real Madrid's struggles continued on Sunday as they battled to a 1-1 draw at Girona in LaLiga.
Real Madrid winger Vinicius Jr issued a public apology on Wednesday after his angry reaction to being substituted during Sunday's heated 2-1 El Clasico victory over Barcelona had him storm straight to the changing rooms.
In an eventful match with plenty of needle, Vinicius was fired up, snapping into tackles and encouraging the crowd to make more noise
Real are on 24 points, two ahead of Barcelona and the top two will go head-to-head in next Sunday's El Clasico. Getafe are 12th in the standings on 11 points.
Argentina's Di Maria to quit internationals after Copa America
Kylian Mbappe scored twice from the penalty spot as Real Madrid fought back from a goal down to beat Olympique de Marseille 2-1 in their opening match of the Champions League group stage, at the Santiago Bernabeu, Madrid, on Tuesday.
Rodrygo struck twice and Vinicius Jr dazzled as Real Madrid beat Osasuna 2-1 on Saturday to win their 20th Copa del Rey title and first since 2014.
The system, featuring three centre backs and aggressive wing backs, marked a significant departure from the traditional 4-3-3 formation and appeared to address Real's defensive frailties from a disappointing, trophyless 2024-25 campaign.
Real outclass Majorca, to meet Barca in Super Cup final
Real Madrid laboured to a 1-1 Club World Cup draw against a spirited Al-Hilal in searing heat on Wednesday
That kept Real top of LaLiga on 50 points, one ahead of Atletico in second who missed a chance to leapfrog them. Barcelona, third on 45 points, visit Sevilla on Sunday with a chance to close the gap in the title race.
Barcelona came from an early goal down to beat Real Madrid 5-2 in the Spanish Super Cup final on Sunday
A Jules Kounde goal in the dying minutes of extra-time handed Barcelona a dramatic 3-2 win over fierce rivals Real Madrid in an enthralling Copa del Rey final on Saturday.
The victory lifted Brazil to second in South American qualifying with 21 points, four behind leaders Argentina and one ahead of Uruguay in third, both of whom have a game in hand and will clash on Friday.
Real booked their place in the final when substitute Arda Guler lifted a corner to Ruediger, who headed the equaliser that put Real Madrid through on aggregate.
Kylian Mbappe was in inspired form, scoring twice to guide Real Madrid to a comeback 4-1 win over visitors Las Palmas on Sunday.
IMAGES from the UEFA Champions League matches played on Wednesday
Brazil, who are fifth in the CONMEBOL table with 18 points from 12 games, host Colombia on March 21 and visit Argentina five days later in a match that could see Neymar come up against former Barcelona and Paris St Germain teammate Lionel Messi.
A round-up of the UEFA Champions League last-16 first leg matches played on Tuesday.
The result means Real, on 49 points, are one point clear of Atletico Madrid, who beat Mallorca 2-0, ahead of next weekend's Spanish capital derby at Santiago Bernabeu.
Villarreal fought back to shock Barcelona 3-2 on Sunday, handing the LaLiga champions their first league defeat since late December.
Kylian Mbappe bagged his first hat-trick for Real Madrid as the LaLiga champions easily beat bottom-club Real Valladolid 3-0 on Saturday
The United States' bid for a fourth consecutive CONCACAF Nations League title came to a stunning end
Real Madrid's Intercontinental Cup triumph marked a remarkable milestone for Carlo Ancelotti on Wednesday as the Italian became the manager with the most titles in the club's history with a total of 15 trophies.
Real Madrid paid for defensive mistakes as they were held to a 3-3 draw at lowly local rivals Rayo Vallecano on Saturday.
'We were happy with the win because we played a great game until the 88th minute, when two lapses in concentration led to two goals and we had to suffer a bit more than we should have.'
Real Madrid got their LaLiga title defence off to a limp start as they were held to a 1-1 draw at Mallorca.
Bundesliga leaders Bayern Munich powered past third-placed Eintracht Frankfurt 4-0 with an impressive display of high-pressing football on Sunday.
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