"A CT scan of Aiden Markram's wrist showed a fracture involving the wrist bones. The medical team has, therefore, ruled him out of the next Test match against India," said Team doctor, Hashendra Ramjee in an official statement.
Joburg Super Kings and Pretoria Capitals claimed crucial victories over Durban's Super Giants and Sunrisers Eastern Cape respectively in the Betway SA20.
South Africa have now won six successive Tests, starting with success in the West Indies in August and following it with two-Test series wins in Bangladesh and then home to Sri Lanka last month.
Proteas edge Pakistan to win thriller at Centurion
Ryan Rickelton struck a career-best unbeaten 176 and his captain Temba Bavuma scored 106 as South Africa pummelled Pakistan's seamers at Newlands to finish the first day of the second and final Test on 316 for four on Friday.
Faf Du Plessis' injury prompted selectors to fast-track the 23 year old to the hot seat.
Australia will be without their premier pacers but their envious pedigree in ICC tournaments make them favourites to progress to the semi-finals of the Champions Trophy from Group B.
South Africa skipper Aiden Markram claimed that batting on a 'slow and fresh' pitch in New York has been tough.
The home side are chasing a modest target of 148 after bowling out Pakistan for 237 and if they win will be assured a place in the WTC final at Lord's.
Sri Lanka used the seamer friendly conditions at Kingsmead to reduce South Africa to 80/4 before rain stopped play on the opening day of the first Test
All about IPL 2025 which kicks off on March 22, Saturday.
Aiden Markram will require surgery and is to be sidelined for six weeks
Sanju Samson will look to continue his domination of the bowlers but India need more stability in the top order
Chasing the modest total, South Africa were down 86 for seven before Stubbs and Coetzee added 42 runs for the eighth wicket to take them home.
Cricket South Africa is hopeful the unique format may catch on, though for many the jury will be out as the slogathon produced entertainment off the bat
Top bowler Kagiso Rabada will be rested for the series, along with Lungi Ngidi, as South Africa look ahead to the two-Test series against Sri Lanka, which begins later in November.
Tony de Zorzi and Tristan Stubbs both scored maiden Test hundreds as the tourists amassed 307 runs for two wickets against Bangladesh
Markram hoped that this would be the first of more finals to come, in particular when South Africa host the 50-over Cricket World Cup in 2027.
Ryan Rickelton scored a maiden Test century as the hosts finished on 269-7 against Sri Lanka on the opening day
Sri Lanka were dismissed for their lowest test total of 42 after South Africa's Marco Jansen produced bowling heroics to help the hosts take a firm grip on the first Test.
IMAGES from the second T20I in Gqeberha played between India and South Africa on Sunday
Varun Chakaravarthy picked up three wickets and gave 25 runs in his four-over and helped the Men in Blue to defend the given target.
A look at the best catches in the CSK-SRH game.
Aiden Markram conceded that Andries Gous made life difficult for his side after the United States put the seasoned South Africans under tremendous stress in their T20 World Cup Super Eight match.
South Africa have recalled all-rounder Senuran Muthusamy to their 15-player squad for next month's two-Test tour of Bangladesh as one of three frontline spin options.
Sanju Samson became the first Indian to hit two consecutive hundreds in T20 Internationals to power the visitors to a thumping 60-run victory against South Africa.
Middle order batsman Mehidy Hasan Miraz led a Bangladesh fight back with an unbeaten 87 on the third day of the first Test against South Africa on Wednesday to turn a precarious position into a tight contest.
Markram's good form augurs well for the Proteas
India's young batter Yashaswi Jaiswal was placed sixth with 714 points.
South Africa declared their first innings at a daunting 575-6 thanks to Tony de Zorzi's 177 and Wiaan Mulder's unbeaten 105, before the tourists reduced Bangladesh to 38-4 on day two
A clinical South Africa skittled Afghanistan for 56 on their way to a comprehensive nine-wicket victory in the first Twenty20 World Cup semi-final.
India's Arshdeep Singh is in the race for the ICC Men's T20I Cricketer of the Year along with Pakistan's Babar Azam, Zimbabwe's Sikandar Raza and Australia's Travis Head, the ICC revealed on Sunday.
Indian batting line-up need to get its mojo back against a resurgent South Africa to regain the lost ground on rather unfamiliar SuperSport Park conditions
The country's woes at World Cups, be it the 50-over or shortest format, are well documented and so the expectations back home have been tempered
Ramandeep Singh showed great composure to settle under a high catch for the key wicket of SRH's Rahul Tripathi.
'He's got the right mindset to dominate as a leader too. He just needs some time'
South Africa have picked the uncapped duo of batter Ryan Rickelton and seamer Ottniel Baartman in their 15-man squad for the T20 World Cup
South Africa's bid to lift a first major cricket trophy could come down to whether they can finally shed the unwanted tag of "chokers".
Karn Sharma took a sharp catch off his own bowling to send back Abdul Samad.
IMAGES from the fourth and deciding T20I played between South Africa and India in Johannesburg on Friday