Griezmann played mainly deep, but also often close to lone striker Giroud or even on the flanks.
Atletico Madrid needed a penalty shootout to edge past Inter Milan and reach the Champions league quarter-finals after a dramatic last-16 clash ended 2-2 on aggregate on Wednesday.
Ernesto Valverde's Bilbao team punished the visitors with clinical counter-attacks, playing with the advantage of having won the first leg 1-0 in Madrid.
Roundup of the matches being held across major football leagues in Europe on Sunday
Barcelona's Raphinha scored deep into stoppage time to hand his side a dramatic 5-4 comeback win at Benfica and a place in the Champions League last 16.
It was Griezmann's combination of graft and guile at both ends of the pitch that caught the eye.
Griezmann thankful for thankless role in France side
Robert Lewandowski and substitute Pablo Torre each scored twice to help leaders Barcelona thrash visitors Sevilla 5-1 in LaLiga on Sunday in a confidence boost for Hansi Flick's side ahead of key clashes against Bayern Munich and Real Madrid.
If this sporting clash was, as English essayist, novelist and journalist George Orwell said, "war minus the shooting" both sets of players were more than ready, and set about each other with little restraint.
IMAGES from the UEFA Champions League matches played on Wednesday.
Real Sociedad will join Atletico Madrid, Real Madrid, and LaLiga champions Barcelona in Europe's elite club competition next season.
Messi hit back last week, saying he was tired of being blamed for problems at Barcelona.
Second-half strikes by Federico Valverde, Brahim Diaz and Endrick gave feeble Real Madrid an unconvincing 3-0 win over lowly Real Valladolid.
Antoine Griezmann's free kick brushed the top of Mandzukic's head and sailed over his own goalkeeper to give France a 1-0 lead in the 18th minute of the game at Moscow's Luzhniki Stadium.
Piotr Zielinski converted two penalties for Inter Milan as they played out a thrilling 4-4 draw with Juventus.
The quarter-final draw was the last in the current format with UEFA adopting an all-new format from the 2024-25 season onwards.
The Euro 2016 has come to an end with Portugal defeating hosts France on Sunday to lift their biggest football title. UEFA, the organising body of European Championships has now revealed the Team of the Tournament for Euro 2016. Four Portugal players, three Germans and two each from France and Wales have made this team, which is selected by a 13-strong panel of technical observers also including legendary Manchester United manager Sir Alex Ferguson.
Raphael Varane's glancing header and a goalkeeping blunder that gifted Antoine Griezmann a soft goal gave France a 2-0 victory over Uruguay in the first World Cup quarter-final on Friday and a set up a last-four tie with Brazil or Belgium.
Denmark levelled seven minutes later, with Christensen making up for the deflection by blasting a powerful header past distraught French goalkeeper Hugo Lloris.
Robert Lewandowski and Raphinha both scored twice to help Barcelona thrash hosts Villarreal 5-1.
IMAGES from football matches played across Europe on Wednesday.
Leverkusen's Schick scores hat-trick in comeback win over Heidenheim.
Following his heroics against world champions Germany in the semifinal at Marseille, France forward Antoine Griezmann has emerged as a clear favourite to bag the Golden Boot award at the 2016 European Championship. Griezmann fired a brace past Germany to take his tournament tally to an astounding six goals. Such has been his dominance that the French magician leads Portugal hero Cristiano Ronaldo (3 goals) by a double margin in the tournament's goal's tally.
Barcelona announced the signing of Griezmann this month for 120 million euros
Antoine Griezmann and Samuel Lino scored in each half to give Atletico Madrid a 2-0 win over Lazio on Wednesday that secured them top spot in Champions League Group E, the first time since 2016 that they had reached the knockouts as group winners.
Messi mania highlights 'epic' year for MLS, Garber says
IMAGES from the FIFA World Cup Group C match played between France and Australia at Kazan Stadium on Saturday
Greece beat England for the first time as striker Vangelis Pavlidis's double earned the visitors a richly-deserved 2-1 victory.
When Barca and Neymar were at the peak of their powers in 2017, however, he shook world football by heading to PSG for a record-smashing 222 million euros ($269.89 million).
Manchester City have one just victory from their last 10 games across all competitions.
Inter Milan captain Lautaro Martinez struck a last-gasp goal to snatch a dramatic 1-0 win over 10-man Napoli as they claimed their third successive Italian Super Cup title on Monday.
The 25-year-old striker, who stands 1.76 metres tall, caught the eye on the big stage against Germany, driving home a penalty at the end of the first half before poking in the ball on 72 minutes following a rare blunder by Germany goalkeeper Manuel Neuer.
Germany, who crashed out at the group stage in the World Cup in Russia, suffered their sixth defeat of 2018.
Barcelona made a disappointing start to their Champions League campaign by losing 2-1 to AS Monaco on Thursday.
New Atletico striker Diego Costa, whose transfer from Chelsea was agreed this week, watched on from the stands as both sides hit the woodwork in the opening 20 minutes of an even first period.
A summary of Wednesday's action in the Champions League quarter-finals first leg.
Kylian Mbappe is now expected to be paired with his favoured attacking partner in Olivier Giroud.
Manchester City squandered a three-goal lead to draw 3-3 with Feyenoord in the Champions League on Tuesday.
The race for Golden Boot award at the 2016 Euro Championship heats up with French players occupying the top three spots ahead of the semi-final round. France forward Antoine Griezmann leads the way in the race followed by his teammates Olivier Giroud and Dimitri Payet.
Girona reclaimed top spot in LaLiga after beating champions Barcelona 4-2