Liverpool resumed their march to a second Premier League title on Sunday with a 2-1 victory over West Ham United.
Graham Potter is in talks to replace Lopetegui, according to British media reports, and the former Chelsea and Brighton & Hove Albion manager is expected to take charge of West Ham for their FA Cup third-round game at Aston Villa on Friday.
Tottenham have not won any silverware since they beat Chelsea in the 2008 League Cup final.
It is the first time since 1989-90 that Manchester United have lost 10 of their first 22 games of the league season.
Barcelona were held to a 0-0 home draw by Galatasaray in the first leg of their Europa League last-16 tie
Images from action in the Europa League matches on Thursday.
Cristiano Ronaldo scored on his return to the starting line-up as Manchester United sealed a place in the Europa League knock-out rounds with a 3-0 victory over Sheriff Tiraspol at Old Trafford on Thursday.
IMAGES from Europa League matches played on Thursday.
Reach fifth round for first time in 10 years
In the third-tier Europa Conference League, English Premier League club Leicester City will face Danish side Randers and Scottish club Celtic will take on Norwegian champions Bodo/Glimt in the knockout playoff round.
Barcelona were shaken up by Eintracht Frankfurt but took a first step in their bid to reach the Europa League last four as a second-half goal by Ferran Torres salvaged a 1-1 comeback away draw in their quarter-final first leg on Thursday.
The match was called off a day before the fixture after Spurs manager Antonio Conte said eight players and five members of staff had tested positive for COVID-19.
United are 13th in the Premier League table and following a 1-1 draw with Dutch side Twente Enschede in the first Europa League match, Ten Hag said speculation about his job was inevitable.
Eintracht Frankfurt beat 10-man West Ham United 1-0 in their Europa League semi-final
Rangers joined Barca in the last eight despite losing 2-1 at Red Star Belgrade, progressing 3-2 on aggregate.
Arsenal's Arteta wary of old foe Villa
Bundesliga leaders Bayern Munich powered past third-placed Eintracht Frankfurt 4-0 with an impressive display of high-pressing football on Sunday.
After a tense encounter finished 1-1 following extra time, Villareal's Rulli stepped up after every on-field player scored their spot kicks and he comfortably beat Spaniard De Gea
Barcelona will face a struggling Galatasaray team who are 13th in the Turkish top-flight.
Napoli kept alive their hopes of advancing from Group C after Lorenzo Insigne, Victor Osimhen and Matteo Politano secured a 3-0 home win over Legia Warsaw.
Manchester City came from behind to beat Club Brugge 3-1 and secure their place in the Champions League playoffs
Images from Europa League matches played on Thursday.
Sevilla in semis as Wolves miss penalty.
Manchester United breezed into the next round with a 6-1 aggregate win over Club Brugge
The draw also produced a clash between two former European champions with AC Milan facing Serbia's Red Star Belgrade while French league leaders Lille face Ajax Amsterdam in a fascinating tie.
IMAGES from Europa League matches played on Thursday.
Moroccan Yassine Bono denied Marcus Rashford, Bruno Fernandes, Mason Greenwood and Anthony Martial in either half of the match to keep the match alive
Mourinho was hired as manager and technical director in June as Fenerbahce chase their first Turkish league title since 2014. He was attempting to get his new team into the revamped 36-team league stage of the Champions League, which he won with Porto in 2004 and Inter Milan in 2010.
Ruud van Nistelrooy will take over on an interim basis.
'We created loads of chances in our seven (Premier League) games but we have to step up.'
Going into the ground, some Israel fans wore both Israeli and French colours. Two wore a t-shirt with Israeli club side Maccabi Tel Aviv's logo on the front and the words "Ni Oubli Ni Pardon" (Never Forgive Never Forget) on the back.
Manchester United, winners of the competition in 2017, will have a lot of travelling to do to Eastern Europe after being drawn alongside Kazakhstan side Astana, Serbia's Partizan Belgrade and Dutch side AZ Alkmaar.
However, there was a softening in tone over eventual cases where league seasons may be cancelled -- an outcome UEFA had been quick to oppose.
A summary of Thursday's matches in the Europa League.
Images from Thursday's action in the Premier League.
Images from UEFA Europa League semi-finals played on Thursday.
Tottenham Hotspur secured a place in the Europa League next season as they closed out their Premier League campaign with a 1-1 draw at Crystal Palace on Sunday.
Ajax keeper Remko Pasveer made five saves and scored on his own attempt to help the hosts win the shootout as Dutch international Brian Brobbey missed two penalties.
Eintracht Frankfurt won the Europa League final after holding their nerve to beat Rangers 5-4 in a clinical penalty shootout as they claimed their first European trophy in 42 years.
Jarrod Bowen converted a last-gasp penalty to lift West Ham United to a 2-1 Premier League victory over Manchester United in a fluctuating clash between two struggling sides on Sunday.
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