The draw also produced a clash between two former European champions with AC Milan facing Serbia's Red Star Belgrade while French league leaders Lille face Ajax Amsterdam in a fascinating tie.
IMAGES from Europa League matches played on Thursday.
Moroccan Yassine Bono denied Marcus Rashford, Bruno Fernandes, Mason Greenwood and Anthony Martial in either half of the match to keep the match alive
It is the first time since 1989-90 that Manchester United have lost 10 of their first 22 games of the league season.
United are 13th in the Premier League table and following a 1-1 draw with Dutch side Twente Enschede in the first Europa League match, Ten Hag said speculation about his job was inevitable.
Manchester United, winners of the competition in 2017, will have a lot of travelling to do to Eastern Europe after being drawn alongside Kazakhstan side Astana, Serbia's Partizan Belgrade and Dutch side AZ Alkmaar.
Tottenham have not won any silverware since they beat Chelsea in the 2008 League Cup final.
However, there was a softening in tone over eventual cases where league seasons may be cancelled -- an outcome UEFA had been quick to oppose.
Liverpool resumed their march to a second Premier League title on Sunday with a 2-1 victory over West Ham United.
Tottenham Hotspur secured a place in the Europa League next season as they closed out their Premier League campaign with a 1-1 draw at Crystal Palace on Sunday.
Images from UEFA Europa League semi-finals played on Thursday.
A summary of Thursday's matches in the Europa League.
Reach fifth round for first time in 10 years
UEFA bowed to the inevitable on Wednesday and suspended all Champions League and Europa League matches 'until further notice' due to the coronavirus pandemic.
The 24 sides through from the group phase join the eight third-placed finishers in the Champions League in Monday's draw, including Manchester United and Ajax Amsterdam.
Eintracht Frankfurt won the Europa League final after holding their nerve to beat Rangers 5-4 in a clinical penalty shootout as they claimed their first European trophy in 42 years.
IMAGES from Europa League matches played on Thursday.
Arsenal's Arteta wary of old foe Villa
AC Milan have been drawn to play Manchester United in what is the standout tie in next month's Europa League round of 16.
Pogba, who rejoined United from Juventus last year, started all 15 games and scored three times in Europe's second-tier competition to help United lift the trophy for the first time in May.
Arsenal can sustain a Europa League challenge but a top-four finish in the Premier League would be the best way to reach next season's Champions League, manager Arsene Wenger has said.
Manchester United were forced to dig deep to reach the Europa League semi-finals as Portuguese midfielder Bruno Fernandes converted a 95th-minute penalty to secure a 1-0 win over a stubborn FC Copenhagen side after extra time on Monday.
Bundesliga leaders Bayern Munich powered past third-placed Eintracht Frankfurt 4-0 with an impressive display of high-pressing football on Sunday.
Rashford scores a brace as Man United fight back to beat Omonia
Mourinho was hired as manager and technical director in June as Fenerbahce chase their first Turkish league title since 2014. He was attempting to get his new team into the revamped 36-team league stage of the Champions League, which he won with Porto in 2004 and Inter Milan in 2010.
UEFA has postponed all Champions League and Europa League matches due to take place next week because of the coronavirus outbreak, European soccer's governing body said in a statement on Friday.
Europe's top club coaches gave their support on Thursday to the much-maligned Europa League.
Manchester City came from behind to beat Club Brugge 3-1 and secure their place in the Champions League playoffs
IMAGES from the Europa League matches played on Thursday
IMAGES from the Europa League matches played on Thursday
'We created loads of chances in our seven (Premier League) games but we have to step up.'
Ruud van Nistelrooy will take over on an interim basis.
Ajax keeper Remko Pasveer made five saves and scored on his own attempt to help the hosts win the shootout as Dutch international Brian Brobbey missed two penalties.
Going into the ground, some Israel fans wore both Israeli and French colours. Two wore a t-shirt with Israeli club side Maccabi Tel Aviv's logo on the front and the words "Ni Oubli Ni Pardon" (Never Forgive Never Forget) on the back.
Manchester United manager Jose Mourinho said Friday's draw for the last 16 of the Europa League against Russian side Rostov has been unkind to his team, the favourites.
Harry Kane netted his 200th goal for Tottenham Hotspur as they won 3-1 at Ludogorets and AC Milan's 24-match unbeaten run ended
Alexandre Lacazette's free-kick sent Arsenal into the Europa League semi-finals with a comfortable 1-0 win away over Napoli, while Chelsea beat Slavia Prague 4-3 in a roller-coaster game, helped by a Pedro brace.
Sevilla clinched a sixth Europa League title with a roller-coaster 3-2 win over Inter Milan after an overhead kick by defender Diego Carlos deflected by the Italian side's top scorer Romelu Lukaku settled a thrilling contest on Friday.
IMAGES from the Europa League semifinal played between Manchester United and Sevilla in Cologne on Sunday.
Roma have taken just four points from their last five league matches, and were eliminated from the Coppa Italia last week in a 1-0 defeat to rivals Lazio.
