West Ham edged Brentford in shootout after Dango Ouattara to attempt a chipped "Panenka" penalty cost his side in their FA Cup fifth round tie on Monday.
Arsenal moved nine points clear in the Premier League after beating Everton 2-0 as 16-year-old Max Dowman became the youngest scorer in league history, while Manchester City dropped points at West Ham.
Liverpool secured a dominant win over West Ham, while other Premier League matches saw Brentford edge Burnley in a seven-goal thriller and Everton secure a late victory against Newcastle.
West Ham United bounced back from conceding an early goal to beat Newcastle United 3-1 on Sunday.
It was Leeds's first win in four league matches but for West Ham their worst start since 1973-74, when they had the same record after nine games.
The commanding scoreline in the cross-town London derby came despite Chelsea's midfield talisman Cole Palmer being ruled out after he felt discomfort on the pitch during the pre-match warmup.
Manchester City will host Liverpool in the FA Cup quarter-finals while Arsenal travel to Southampton as the last-eight draw sets up a blockbuster clash.
Substitute Jorgen Strand Larsen scored twice in two minutes as Wolverhampton Wanderers beat fellow Premier League strugglers West Ham United 3-2 to reach the third round of the League Cup on Tuesday.
British media reported the deal is worth around 55 million pounds for Ghana's Mohammed Kudus, who turns 25 next month.
Manchester City defeated Salford City in the FA Cup, while Burnley suffered a surprising defeat to Mansfield Town. West Ham United and Norwich City also secured victories in their respective matches.
Manchester United's Benjamin Sesko scoring a stoppage-time equaliser to deny 18th-placed West Ham United a 1-0 win.
Arsenal teenager Max Dowman made Premier League history by scoring at 16 years and 73 days in a 2-0 win over Everton, becoming the youngest scorer in the competition.
City, Liverpool all cruise in respective FA Cup matches played on Saturday.
Goals from Omar Marmoush and Antoine Semenyo powered Manchester City to a muchneeded 20 home win over Wolverhampton Wanderers on Saturday, lifting Pep Guardiola's men provisionally to within four points of leaders Arsenal in the Premier League title race.
Manchester United defeated Aston Villa to strengthen their position in the Premier League top four, while Liverpool were held to a draw by Tottenham Hotspur.
Chelsea battled from two goals down to beat West Ham 3-2 in the Premier League on Saturday with a stoppage-time Enzo Fernandez winner.
Southampton secured a 1-0 victory against Fulham with a late penalty, making them the first non-Premier League club to reach the FA Cup quarter-finals this season.
Brentford scraped into the FA Cup fifth round with a narrow 1-0 win over sixth-tier Macclesfield, sealed by Sam Heathcote's second-half own goal after a spirited display from the hosts.
Arsenal extends its lead in the Premier League, while Manchester United strengthens its top-four bid. Chelsea's Cole Palmer shines with a hat-trick, and West Ham earns a crucial win in their fight against relegation.
Graham Potter is in talks to replace Lopetegui, according to British media reports, and the former Chelsea and Brighton & Hove Albion manager is expected to take charge of West Ham for their FA Cup third-round game at Aston Villa on Friday.
Andy Robertson scored once and set up Mohamed Salah as Liverpool beat Wolves 3-1 at Molineux to reach the FA Cup quarter-finals, while Tottenham Hotspur's Premier League woes deepened after a 3-1 home defeat to Crystal Palace, extending their winless run to 11 matches.
Wolverhampton Wanderers stun Liverpool 2-1 with a 94th-minute winner to revive survival hopes and dent the Reds' top-five push, while Everton and Sunderland claim crucial Premier League victories.
Arsenal seized control of the Premier League title race as Bukayo Saka's goal secured a priceless 1-0 win at Brighton and Hove Albion and Manchester City could only draw 2-2 at home to relegation-threatened Nottingham Forest.
Benjamin Sesko came off the bench to score the winner as Manchester United beat Everton 1-0 in the Premier League, strengthening their hold on fourth place under Michael Carrick.
West Ham beat Premier League strugglers Leicester City 2-0 at the London Stadium on Thursday thanks to an early strike from Tomas Soucek on his 30th birthday and an own goal just before halftime.
Manchester City climbed back to the top of the table with a ruthless 3-0 dismantling of West Ham United on Saturday, as Erling Haaland bagged a double to top Cristiano Ronaldo's Premier League goals tally in less than half the time.
Manchester United missed the chance to go fifth in the Premier League when they were held 1-1 by West Ham United at Old Trafford on Thursday, a result which keeps the visitors in the relegation zone.
Arsenal maintained control of the Premier League title race as they chiselled out a nervy 2-1 win over London rivals Chelsea to open up a five-point lead at the top of the table on Sunday.
IMAGES from the EPL matches played on Sunday
Chelsea recovered to beat West Ham United 2-1 to jump to fourth place in the English Premier League on Monday.
Aston Villa and Chelsea drop crucial points in the Premier League as Leeds and Burnley earn draws; James Milner sets appearance record.
Premier League leaders Arsenal ended their mini-slump with an emphatic 4-0 victory at Leeds United on Saturday to move seven points clear despite Bukayo Saka being ruled out through injury just before kickoff.
Manchester City halved Arsenal's lead at the top of the Premier League to three points with a 3-0 win over visitors Fulham, while Aston Villa stayed in the frame with a late 1-0 victory at home to Brighton & Hove Albion on Wednesday.
Arsenal beat Bournemouth 3-2 on Saturday to extend their lead at the top of the English Premier League.
West Ham United eased the pressure on new manager Julen Lopetegui with a surprise 2-0 victory away to in-form Newcastle United in the Premier League on Monday.
The game featured a minute's applause after the ninth minute for 34-year-old Hammers striker Michail Antonio, who is recovering in hospital following surgery on a fractured leg sustained in a car crash on Saturday.
Manchester City maintained their squeeze on Arsenal at the top of the Premier League with a 3-0 victory at Crystal Palace on Sunday, a result that keeps Pep Guardiola's side lurking two points behind the leaders and ready to pounce.
Manchester United loosened Arsenal's grip on the Premier League title race with a 3-2 win in north London on Sunday.
Images from Saturday's action in the Premier League.
Liverpool could be 14th in the table by the time they kick off at West Ham on Sunday afternoon and they will be desperate to steady the ship with three points.
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