Manchester City maintained their squeeze on Arsenal at the top of the Premier League with a 3-0 victory at Crystal Palace on Sunday, a result that keeps Pep Guardiola's side lurking two points behind the leaders and ready to pounce.
IMAGES from the UEFA Champions League matches played on Tuesday
Promoted Sunderland, who have defied expectations to stay in the top half of the Premier League table, could be the worst affected with six players going to the tournament, while the likes of Fulham, Manchester United, Burnley and Crystal Palace will also have to make do without some key personnel.
Arsenal missed a chance to tighten their grip on the Premier League title race with a 1-1 draw at 10-man Chelsea on Sunday.
The Egypt forward has been left out of the club's Champions League match against Inter Milan.
Liverpool could be 14th in the table by the time they kick off at West Ham on Sunday afternoon and they will be desperate to steady the ship with three points.
Premier League leaders Arsenal needed two own goals, the second deep in stoppage time, to scrape a 2-1 home win over bottom club Wolverhampton Wanderers and open a five-point gap, while earlier on Saturday Mohamed Salah put aside a tumultuous week to help Liverpool beat Brighton and Hove Albion 2-0.
Goals from Pedro Neto and Enzo Fernandez earned Chelsea a 2-0 victory at lowly Burnley on Saturday, a win that moved the Blues within three points of Premier League leaders Arsenal.
Substitute Jorgen Strand Larsen scored twice in two minutes as Wolverhampton Wanderers beat fellow Premier League strugglers West Ham United 3-2 to reach the third round of the League Cup on Tuesday.
Everton enjoyed their first Premier League win at Manchester United for 12 years despite playing virtually the entire game with 10 men.
The commanding scoreline in the cross-town London derby came despite Chelsea's midfield talisman Cole Palmer being ruled out after he felt discomfort on the pitch during the pre-match warmup.
IMAGES from Premier League matches played on Saturday
The Croatian replaced Sam Allardyce in June 2015 and led the club to a seventh-placed finish in his first season. He also oversaw their move to the London Stadium last season, but has won just two out of 11 league games in the current campaign.
Arsenal marked Mikel Arteta's 300th game in charge with a convincing 2-0 home victory over West Ham United in the Premier League on Saturday.
West Ham United have sacked Italian manager Gianfranco Zola, the Premier League club said on Tuesday.
A summary of Saturday's action in the Premier League.
The 500 million pounds 2012 London Olympic stadium is reportedly at the centre of a corruption scandal.
Manchester United played out a 2-2 draw against Everton in a pre-season match on Sunday.
British media reported the deal is worth around 55 million pounds for Ghana's Mohammed Kudus, who turns 25 next month.
Bryan Mbeumo hit new heights in the 2024-25 league season, finishing with 20 goals to help Brentford to a solid 10th-place finish.
Fresh off a dominant title-winning campaign, Liverpool kick off the new Premier League season on Friday as the team to beat, as the Reds have transitioned from Juergen Klopp's high-octane chaos to a more measured possession-based style under Arne Slot.
News of all that's transpired on and off the football field
Liverpool's Dominik Szoboszlai struck the first telling blow in the Premier League title race with a dazzling free kick late on giving his side a 1-0 victory over rivals Arsenal.
Winning back-to-back titles for the first time since 1984 is likely to prove a rather more arduous challenge for Liverpool.
Nearly two decades later, Aditi Chauhan retires as a trailblazer, having become the first Indian woman to play professional football in Europe.
A round-up of Saturday's action in the Premier League.
Newcastle United registered a 2-0 home win over Chelsea on Sunday that moves the Magpies a step closer to Champions League football next season.
Liverpool resumed their march to a second Premier League title on Sunday with a 2-1 victory over West Ham United.
Chelsea recovered to beat West Ham United 2-1 to jump to fourth place in the English Premier League on Monday.
Soucek noticed the danger and stopped celebrating, holding up the hoarding so the terrified child could wriggle out, with Bowen, who had been on Soucek's back, pulling him through his teammate's legs to safety.
West Ham United eased the pressure on new manager Julen Lopetegui with a surprise 2-0 victory away to in-form Newcastle United in the Premier League on Monday.
Man United boss Amorim says he has no plans to quit
Arsenal snapped a season-long jinx against Newcastle United with a nervy 1-0 win in their last Premier League home game on Sunday.
'...So that tells you the resilience, resources, the ambition the team has.'
Images from Saturday's action in the Premier League.
Liverpool moved one win away from sealing the Premier League title as substitute Trent Alexander-Arnold secured a 1-0 victory at Leicester City
West Ham beat Premier League strugglers Leicester City 2-0 at the London Stadium on Thursday thanks to an early strike from Tomas Soucek on his 30th birthday and an own goal just before halftime.
IMAGES from the Premier League matches played on Tuesday.
Champions Manchester City struggled in this campaign and sit sixth in the table after winning only two of their last 10 league matches.
The game featured a minute's applause after the ninth minute for 34-year-old Hammers striker Michail Antonio, who is recovering in hospital following surgery on a fractured leg sustained in a car crash on Saturday.
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