Alcaraz, whose tournament so far has been typified by lapses in concentration and drops in intensity, was on the back foot as Medvedev clinched the first set in a tiebreak.
Third seed Andrey Rublev suffered a first round exit after his Qatar Open title, losing to qualifier Quentin Halys 3-6, 6-4, 7-6(5) at the Dubai Open on Tuesday.
Sinner won in Cincinnati this week to claim his fifth title of a breakout season before the revelation that he avoided a ban over two positive tests
Factbox on Italy's Jannik Sinner, who beat Germany's Alexander Zverev 6-3, 7-6(4), 6-3 in the Australian Open final
Taylor Fritz moved closer to the semis of the season-ending ATP Finals after the American beat Alex de Minaur 5-7 6-4 6-3 in their last group game on Thursday, but he will have to wait and see if Jannik Sinner can take a set off Daniil Medvedev.
The unpredictable nature of the 2024 US Open has turned it into one of the most thrilling Grand Slam tournaments in recent memory.
Carlos Alcaraz defeated Tallon Griekspoor of the Netherlands 6-1, 6-2 at the China Open on Sunday to capture his 200th career tour victory.
Australian Open chief Craig Tiley said on Thursday he expects to see Australian former Wimbledon finalist Nick Kyrgios back in action at Melbourne Park.
World number one Jannik Sinner's bid for a second Grand Slam title continued to gain momentum as he thumped Christopher O'Connell 6-1, 6-4, 6-2 on Saturday to reach the US Open fourth round.
Jannik Sinner retained his Australian Open title with an emphatic 6-3, 7-6(4), 6-3 win over Alexander Zverev on Sunday
Medvedev battles back to beat Ruusuvuori
The party atmosphere inside Louis Armstrong Stadium was starkly different from the last time Medvedev and O'Connell stood across from each other during the dark days of COVID-19 restrictions.
Djokovic looked in fine nick in Shanghai, playing with consistency throughout the tournament to reach his fifth final at the ATP Masters 1000 event
'It's one of the most epic matches I have played on this court, on any court really.'
Carlos Alcaraz suffered a shock 6-1, 7-5 defeat against Norway's Casper Ruud in his opening match at the ATP Finals
Carlos Alcaraz failed to reach the Paris Masters quarter-finals after a thrilling 6-1, 3-6, 7-5 defeat to local favourite Ugo Humbert
Jannik Sinner won his maiden Grand Slam title at the Australian Open on Sunday.
Jannik Sinner made it two wins out of two at the ATP Finals as he fought off Taylor Fritz in a high-octane clash inside the Inalpi Arena on Tuesday.
Jannik Sinner bounced back from two sets down to beat Daniil Medvedev and win his maiden Grand Slam title.
Here is what you need to know about the prize pot on offer at the 2024 US
'That's the motto: the future is bright. This year hopefully I can play better in Australian Open and go further and show some good tennis.'
The Wimbledon men's singles semi-finals take centre stage at the All England Club on Friday.
The Russian, twice a losing finalist at Melbourne Park, went toe-to-toe with the big Pole for almost four energy-sapping hours on Rod Laver Arena
Jannik Sinner has withdrawn from the Paris Games due to tonsillitis.
Images from Day 7 of the 2025 Australian Open at Melbourne Park on Saturday.
Jannik Sinner has sprinted past opponents at the Australian Open in his quest for a maiden Grand Slam but could end up running a marathon in the final against Daniil Medvedev on Sunday, when Melbourne Park will crown a new king.
Alexander Zverev said his energy began to fade midway through his five-sets Australian Open semi-final loss to Daniil Medvedev
Alcaraz topped the Red Group and will face Green Group runner-up Novak Djokovic in a mouth-watering semi-final.
Medvedev on everyone's US Open radar after first round rout
IMAGES from Day 9 of the Wimbledon Championships, at the All England Lawn Tennis and Croquet Club, London, on Tuesday.
At the age of 36, Novak Djokovic is the fourth oldest Grand Slam champion of the Open era.
'I had some nerves but if you want to beat one of these guys you have to be unbelievably calm and keep your head there.'
Carlos Alcaraz won two matches to lift Team Europe to a 13-11 victory over Team World for the Laver Cup title in Berlin.
Second seed Aryna Sabalenka beat Japanese qualifier Moyuka Uchijima 6-2 6-2 under the roof on Court Philippe-Chatrier on Thursday to move into the French Open third round.
Bulgarian Grigor Dimitrov defeated Alexander Zverev 6-4, 6-7(4), 6-4 in a thrilling contest on Friday to reach the Miami Open final, where he will face world number three Jannik Sinner.
'Can't leave grass,' the 26 year old captioned an image posted on his social media pages.
Athletes from Russia and Belarus, Moscow's closest ally in the 2022 invasion of Ukraine, are barred from the Paris Games except for the few who will compete as neutral athletes without flags or anthems.
IMAGES from the Australian Open Men's semi-finals played on Friday.
Carlos Alcaraz powered into the Australian Open quarter-finals for the first time on Monday
IMAGES from Day 7 of the Wimbledon Championships, at the All England Lawn Tennis and Croquet Club, London, on Sunday.