Nottingham Forest, who finished seventh in the Premier League last season, will replace Palace in the Europa League.
Brentford scraped into the FA Cup fifth round with a narrow 1-0 win over sixth-tier Macclesfield, sealed by Sam Heathcote's second-half own goal after a spirited display from the hosts.
Man City snatch chaotic 2-1 win at Liverpool to stay on Arsenal's heels
Images from the Premier League match between Nottingham Forest and Crystal Palace at Selhurst Park, London, on Monday.
Liam Rosenior hailed 18-year-old Estevao's impact as Chelsea sealed their third straight win with a 3-1 victory over Crystal Palace.
Images from the FA Cup semi-final between Crystal Palace and Aston Villa at Wembley stadium, London, on Saturday.
Crystal Palace forward Jean-Philippe Mateta was taken to hospital with a head injury after a collision with Millwall goalkeeper Liam Roberts.
Crystal Palace's Eberechi Eze sparked a massive south London party by scoring the only goal to win the FA Cup 1-0 against Manchester City on Saturday and claim the club's first major trophy in their history.
Images from Saturday's FA Cup quarter-finals.
Manchester United loosened Arsenal's grip on the Premier League title race with a 3-2 win in north London on Sunday.
Non-league Macclesfield produced perhaps the FA Cup's greatest upset on Saturday when they beat holders Crystal Palace 2-1 in a thirdround thriller, knocking Oliver Glasner's team out of the competition and sending the Moss Rose crowd into raptures.
Newcastle United thumped Crystal Palace 5-0 at St James' Park on Wednesday to go third in the Premier League table with a sixth consecutive win in all competitions as Jacob Murphy scored one goal and set up another.
Arsenal edged past Crystal Palace on penalties on Tuesday to reach the semi-finals of the League Cup.
Manchester City defeated Salford City in the FA Cup, while Burnley suffered a surprising defeat to Mansfield Town. West Ham United and Norwich City also secured victories in their respective matches.
Manchester City halved Arsenal's lead at the top of the Premier League to three points with a 3-0 win over visitors Fulham, while Aston Villa stayed in the frame with a late 1-0 victory at home to Brighton & Hove Albion on Wednesday.
City, Liverpool all cruise in respective FA Cup matches played on Saturday.
A makeshift United defence that included Casemiro at centre-back was easily picked apart by Palace on several occasions
Crystal Palace have never won the FA Cup, Aston Villa last lifted the trophy in 1957 and Nottingham Forest have not managed it since 1959 but all three clubs go into this weekend's semi-finals genuinely believing this could be their year.
Arsenal's Premier League title prospects were enhanced without them even kicking a ball on Wednesday as their closest challengers Manchester City and Aston Villa both dropped points.
Goals from Omar Marmoush and Antoine Semenyo powered Manchester City to a muchneeded 20 home win over Wolverhampton Wanderers on Saturday, lifting Pep Guardiola's men provisionally to within four points of leaders Arsenal in the Premier League title race.
LATE MILEY GOAL SENDS NEWCASTLE THROUGH
IMAGES from the EPL matches played on Sunday
Gabriel Martinelli scored his first hat-trick for Arsenal as the Premier League leaders beat second-tier strugglers Portsmouth 4-1 to reach the FA Cup fourth round.
Chelsea battled from two goals down to beat West Ham 3-2 in the Premier League on Saturday with a stoppage-time Enzo Fernandez winner.
Promoted Sunderland, who have defied expectations to stay in the top half of the Premier League table, could be the worst affected with six players going to the tournament, while the likes of Fulham, Manchester United, Burnley and Crystal Palace will also have to make do without some key personnel.
From Royal Challengers Bengaluru's historic first IPL title to star javelin thrower Neeraj Chopra finally breaking the iconic 90-meter mark to India women winning their first cricket World Cup, this was the year of long-awaited victories and record-breaking feats.
Championship side Oxford United beat League Two's MK Dons on penalties after their match ended 1-1, while a couple of League One teams moved on, with Wigan Athletic beating Championship side Preston North End 1-0, and Port Vale defeating League Two's Fleetwood Town 1-0.
Manchester City maintained their squeeze on Arsenal at the top of the Premier League with a 3-0 victory at Crystal Palace on Sunday, a result that keeps Pep Guardiola's side lurking two points behind the leaders and ready to pounce.
Arsenal missed a chance to tighten their grip on the Premier League title race with a 1-1 draw at 10-man Chelsea on Sunday.
IMAGES from the Premier League matches played on Sunday
Christensen, Rashford on target as Barcelona beat Guadalajara in Copa del Rey
Cash on target as Villa hand Man City their first defeat since August
Premier League leaders Arsenal needed two own goals, the second deep in stoppage time, to scrape a 2-1 home win over bottom club Wolverhampton Wanderers and open a five-point gap, while earlier on Saturday Mohamed Salah put aside a tumultuous week to help Liverpool beat Brighton and Hove Albion 2-0.
Arsenal's Max Dowman impressed manager Mikel Arteta as he became the club's youngest starter at just 15 years and 302 days in Wednesday's 2-0 League Cup win over Brighton & Hove Albion, earning the coach's praise for his impact in the game.
Second-string Liverpool were thumped 3-0 by Crystal Palace as Ismaila Sarr struck twice for the visitors in the League Cup on Wednesday, booking the London side's spot in the quarter-finals and piling more misery on Arne Slot's struggling side.
Arsenal re-established their five-point lead at the top of the Premier League with a 2-0 home win against Brentford on Wednesday and for the second evening running the goals flowed as Aston Villa won 4-3 in a thriller at Brighton and Hove Albion.
IMAGES from the Premier League matches played on Sunday
'I don't think that's fair, because we have other competitions as well we have to try to accommodate.'
Eberechi Eze scored a majestic hat-trick as Arsenal trounced north London rivals Tottenham Hotspur 4-1 to open up a commanding six-point lead.
Arsenal maintained a searing pace at the top of the Premier League with a straightforward 2-0 win at Burnley, while Liverpool snapped a dreadful four-match losing run with a 2-0 victory over Aston Villa to climb provisionally to third.
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