West Ham draw 0-0 with Crystal Palace to stay just above the relegation zone, while Wolves are officially relegated from the Premier League after a poor season.
Liverpool forward Mohamed Salah will miss the crunch clash against Manchester United due to injury, but manager Arne Slot confirms his return before season end.
Nottingham Forest, who finished seventh in the Premier League last season, will replace Palace in the Europa League.
Liverpool edged closer to Champions League qualification with a 3-1 victory over Crystal Palace at Anfield on Saturday, but the result came with a sour note as Mohamed Salah went off with a suspected hamstring injury.
Mikel Arteta insists the Premier League title race "starts again" after Arsenal's 2-1 loss to Manchester City, with five games left and everything still to play for.
Images from the Premier League match between Nottingham Forest and Crystal Palace at Selhurst Park, London, on Monday.
Images from the FA Cup semi-final between Crystal Palace and Aston Villa at Wembley stadium, London, on Saturday.
Crystal Palace forward Jean-Philippe Mateta was taken to hospital with a head injury after a collision with Millwall goalkeeper Liam Roberts.
Images from Saturday's FA Cup quarter-finals.
Nottingham Forest and Aston Villa reach the Europa League semi-finals, while Braga and Freiburg also advance in a dramatic night of European action.
Crystal Palace's Eberechi Eze sparked a massive south London party by scoring the only goal to win the FA Cup 1-0 against Manchester City on Saturday and claim the club's first major trophy in their history.
Wolverhampton Wanderers and Sunderland have condemned the racial abuse directed at their players on social media following recent Premier League defeats.
Manchester City and Arsenal face off in a crucial Premier League clash, with the title race hanging in the balance as City look to seize momentum.
Brentford scraped into the FA Cup fifth round with a narrow 1-0 win over sixth-tier Macclesfield, sealed by Sam Heathcote's second-half own goal after a spirited display from the hosts.
Newcastle United thumped Crystal Palace 5-0 at St James' Park on Wednesday to go third in the Premier League table with a sixth consecutive win in all competitions as Jacob Murphy scored one goal and set up another.
A makeshift United defence that included Casemiro at centre-back was easily picked apart by Palace on several occasions
Man City snatch chaotic 2-1 win at Liverpool to stay on Arsenal's heels
Liam Rosenior hailed 18-year-old Estevao's impact as Chelsea sealed their third straight win with a 3-1 victory over Crystal Palace.
Andy Robertson scored once and set up Mohamed Salah as Liverpool beat Wolves 3-1 at Molineux to reach the FA Cup quarter-finals, while Tottenham Hotspur's Premier League woes deepened after a 3-1 home defeat to Crystal Palace, extending their winless run to 11 matches.
Crystal Palace have never won the FA Cup, Aston Villa last lifted the trophy in 1957 and Nottingham Forest have not managed it since 1959 but all three clubs go into this weekend's semi-finals genuinely believing this could be their year.
Arsenal maintained control of the Premier League title race as they chiselled out a nervy 2-1 win over London rivals Chelsea to open up a five-point lead at the top of the table on Sunday.
Manchester United loosened Arsenal's grip on the Premier League title race with a 3-2 win in north London on Sunday.
Non-league Macclesfield produced perhaps the FA Cup's greatest upset on Saturday when they beat holders Crystal Palace 2-1 in a thirdround thriller, knocking Oliver Glasner's team out of the competition and sending the Moss Rose crowd into raptures.
Arsenal edged past Crystal Palace on penalties on Tuesday to reach the semi-finals of the League Cup.
Manchester United defeated Aston Villa to strengthen their position in the Premier League top four, while Liverpool were held to a draw by Tottenham Hotspur.
Arsenal seized control of the Premier League title race as Bukayo Saka's goal secured a priceless 1-0 win at Brighton and Hove Albion and Manchester City could only draw 2-2 at home to relegation-threatened Nottingham Forest.
Liverpool secured a dominant win over West Ham, while other Premier League matches saw Brentford edge Burnley in a seven-goal thriller and Everton secure a late victory against Newcastle.
Manchester City defeated Salford City in the FA Cup, while Burnley suffered a surprising defeat to Mansfield Town. West Ham United and Norwich City also secured victories in their respective matches.
Manchester City halved Arsenal's lead at the top of the Premier League to three points with a 3-0 win over visitors Fulham, while Aston Villa stayed in the frame with a late 1-0 victory at home to Brighton & Hove Albion on Wednesday.
City, Liverpool all cruise in respective FA Cup matches played on Saturday.
Arsenal's Premier League title prospects were enhanced without them even kicking a ball on Wednesday as their closest challengers Manchester City and Aston Villa both dropped points.
LATE MILEY GOAL SENDS NEWCASTLE THROUGH
IMAGES from the EPL matches played on Sunday
Goals from Omar Marmoush and Antoine Semenyo powered Manchester City to a muchneeded 20 home win over Wolverhampton Wanderers on Saturday, lifting Pep Guardiola's men provisionally to within four points of leaders Arsenal in the Premier League title race.
Promoted Sunderland, who have defied expectations to stay in the top half of the Premier League table, could be the worst affected with six players going to the tournament, while the likes of Fulham, Manchester United, Burnley and Crystal Palace will also have to make do without some key personnel.
Gabriel Martinelli scored his first hat-trick for Arsenal as the Premier League leaders beat second-tier strugglers Portsmouth 4-1 to reach the FA Cup fourth round.
From Royal Challengers Bengaluru's historic first IPL title to star javelin thrower Neeraj Chopra finally breaking the iconic 90-meter mark to India women winning their first cricket World Cup, this was the year of long-awaited victories and record-breaking feats.
Michael Olise scored a stoppage-time penalty as Crystal Palace clawed back from two goals down to draw 2-2 with Manchester City in the Premier League at the Etihad Stadium on Saturday.
Chelsea battled from two goals down to beat West Ham 3-2 in the Premier League on Saturday with a stoppage-time Enzo Fernandez winner.
Championship side Oxford United beat League Two's MK Dons on penalties after their match ended 1-1, while a couple of League One teams moved on, with Wigan Athletic beating Championship side Preston North End 1-0, and Port Vale defeating League Two's Fleetwood Town 1-0.