Local favourite Thompson saved three match points before prevailing 5-7, 7-6 (6), 6-3 against Nadal, who was playing his first tournament after nearly a year out with a hip injury.
Seven-time Grand Slam champion Venus Williams and former world number three Elina Svitolina were handed wildcard entries into Wimbledon.
Williams playing at a 'better level' after injury-hit start to season
Coco Gauff battled past Elina Svitolina in the Auckland Classic final on Sunday to retain her title.
Hurkacz, Swiatek win as Poland march into United Cup final
Images from Day 4 of the 2023 Wimbledon Championships.
Tan had to be assisted off court in a wheelchair at the Australian Open after suffering calf problems
Images from Day 1 of the 2024 Australian Open in Melbourne on Sunday.
Swiatek is positioned to face American fourth seed Jessica Pegula in the semi-finals.
Aryna Sabalenka said at the French Open that she did not want her country to be in any conflict and did not support the war in Ukraine.
IMAGES from matches on Day 4 of the US Open at Flushing Meadows in New York on Thursday.
Venus has no plans of following her younger sister into retirement any time soon.
Images from Day 2 of the 2024 Australian Open in Melbourne on Monday.
Wimbledon was the only Grand Slam to ban competitors from Russia and Belarus last year.
Ons Jabeur stands on the verge of history with a maiden Grand Slam title at Wimbledon within her grasp but in Czech surprise package Marketa Vondrousova she faces a final opponent who could tear up the script and prolong her wait.
Dominic Thiem defeated qualifier Facundo Bagnis of Argentina 6-4, 7-5 in the first round of the Plava Laguna Croatia Open Umag
Unseeded Marketa Vondrousova of the Czech Republic stunned Tunisia's Ons Jabeur 6-4 6-4 to win the Wimbledon women's singles final on Saturday.
The decision to lift the ban was met with protest from Ukraine, whose Foreign Minister Dmytro Kuleba said it was "immoral" and urged Britain to deny Russian and Belarusian players visas.
IMAGES from Day 6 of the French Open at Roland Garros in Paris on Friday.
Stefanos Tsitsipas enjoyed an incident-free path into the third round of the French Open with a win over Roberto Carballes Baena.
'She said YES Madame MONFILS @elisvitolina #July2021 (XV)(III)', the Frenchman captioned a picture with Svitolina donning a sizable diamond ring and Monfils in the background.
Images from Day 8 of the 2023 French Open at Roland Garros in Paris on Sunday.
IMAGES from Day 6 of the 2023 US Open on Saturday.
Images from Day 10 of the 2023 French Open at Roland Garros in Paris on Tuesday.
Murray knocked out by Fritz in Washington
The couple, who got engaged in April this year, have been dating since 2018.
Top-seeded Elina Svitolina of Ukraine, wearing her national colors of blue and yellow, won on "a special night for me," beating Russia's Anastasia Potapova 6-2, 6-1 on Tuesday in the first round of the Abierto GNP Seguros in Monterrey, Mexico.
Elina Svitolina said she will donate her prize money from WTA tournaments to Ukraine's military and to help with humanitarian efforts following Russia's invasion of her country last week.
Wimbledon debutant Eubanks ends Tsitsipas's challenge in fourth round.
Former US Open champion Svetlana Kuznetsova has joined a growing list of players who have decided not to play in this year's tournament due to concerns over the COVID-19 pandemic.
IMAGES from Day 1 of all the action from the Wimbledon Championships played at the All England Lawn Tennis and Croquet Club, London, on Monday.
After two straight wins, India went down 1-3 to a formidable Russian team in a fourth Pool A match in the FIDE World Women's Team Chess Championship, in Sitges, Spain.
Geopolitical tensions simmered at the US Open on Thursday as Ukrainian Marta Kostyuk refused the customary handshake at the net when Belarusian Victoria Azarenka defeated her 6-2, 6-3 in the second round.
While Monfils's and Svitolina's relationship has blossomed, so have their respective games.
World number 12 Belinda Bencic dug deep to overpower the Czech Republic's Marketa Vondrousova 7-5, 2-6, 6-3 on Saturday and win the Tokyo Games women's singles title, becoming the first Swiss woman to earn an Olympics tennis gold.
Overpowers Svitolina to reach second straight US Open final
Former French Open champion Jelena Ostapenko is the latest player to withdraw from the US Open, organisers of the tennis Grand Slam confirmed on Monday.
Grand Slam champions Daniil Medvedev from Russia and Belarusian Victoria Azarenka will not be able to participate in the June 27-July 10 tournament.
Ukrainian Svitolina came into the match riding high on a nine-match winning streak from the start of the season but, hampered by a hip injury, was completely outplayed by the aggressive Belgian on Rod Laver Arena.
The actors turned showstoppers for Shahin Mannan and Nirmooha respectively.
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