Srikanth lost 21-23, 8-21 to Korea's Chia Hao Lee, continuing his dismal run in international circuit this season.
Indian shuttler Kiran George says his giant-killing act at the Thailand Open Super 500 tournament earlier this year gave him the self-belief, which proved to be the key en route his second BWF title at the Indonesia Masters.
Both Sen and Srikanth are fighting to be inside the top 16 by April 28 next year to qualify for the Paris Olympics.
Prannoy registered a 21-18, 22-20 win over the world number 12 Chen
Young shuttler Tanisha Crasto believes she and doubles partner Ashwini Ponnappa have the game to match the world's best.
The CM expressed hope that budding athletes and sportspersons in the state can take inspiration from his achievement and adopt the same attitude of hard work and dedication shown by the Indian shuttler.
World No. 15 Sindhu, who will be eyeing her third Olympic medal at the Paris Games in two months time, will face second seed and world no. 7 Wang Zhi Yi of China in the summit clash.
The tie was already inconsequential for HS Prannoy as he had lost his earlier two Group A matches.
Eyeing a third Olympic medal, ace Indian shuttler PV Sindhu will now move her base from Hyderabad to Bengaluru to train under the legendary Prakash Padukone in the build-up to the Paris Games.
Prannoy is only seeded Indian player at No. 7 in the men's singles draw of 32 as he will begin his campaign against Loh Kean Yew of Singapore, against whom the Indian has a 4-1 win-loss record.
Bornil Aakash Changmai became only the second Indian shuttler to win a gold medal in the Under-15 boys' singles category.
Two-time Olympic medallist Sindhu will next play Japan's Natsuki Nidaira, while Sen will be up against Ygor Coelho of Brazil.
Chirag Shetty and Satwiksairaj Rankireddy bagged the biggest title of their career, winning the French Open Super 750 crown with a straight-game decimation of Chinese Taipei's Lu Ching Yao and Yang Po Han in the men's doubles final in Paris on Sunday.
Sindhu, Sen look to regain lost touch in Canada Open
Young Kidambi Srikanth continued his meteoric rise in world badminton as he ended the season by becoming only the third Indian male shuttler to break into the top-five, reaching a career-high fourth after hovering in the 40s in the beginning of the year.
Srikanth, Prannoy enter pre-quarters; Aakarshi knocked out
Double Olympic medallist PV Sindhu, who hasn't played any tournament since the Birmingham Games due to an ankle injury, is now world number five after moving up a spot.
P V Sindhu and Aakarshi Kashyap advanced to the women's singles second round at the Denmark Open Super 750 badminton tournament.
In the men's doubles, Satwiksairaj Rankireddy and Chirag Shetty maintained their world number two ranking, although they lost in the quarter-finals of the World Championships going down to Kim Astrup-Anders Rasmussen.
BWF said that Finland will host the Sudirman Cup Finals in September-October while the season-ending World Tour Finals will be staged in Indonesia.
HS Prannoy had almost given up on winning his next title and breaking a six-year long drought before chief national coach Pullela Gopichand instilled in him the belief.
HS Prannoy secured his maiden BWF World Tour title
Satwiksairaj Rankireddy and Chirag Shetty entered the final of the Korea Open Super 500 badminton tournament with a thrilling straight-games victory over the world No.2 Chinese pair of Liang Wei Keng and Wang Chang, in Yeosu, on Saturday.
Rankireddy and Shetty won 21-12, 21-16 in a quarterfinal match that lasted 49 minutes.
Chief national badminton coach Pullela Gopichand on Monday singled out world number one doubles pair of Satwiksairaj Rankireddy and Chirag Shetty as favourites for an Olympic medal and said two-time medallist PV Sindhu too is on the right path and can deliver once again at the Paris Games.
Swiss Open champion Satwiksairaj Rankireddy and Chirag Shetty strengthened their world number six position, while women's doubles pairing of Treesa Jolly and Gayatri Gopichand was static at the 18th position.
The struggle of Indian women shuttlers on the BWF circuit is quite apparent, but Saina Nehwal backs her colleagues by saying that even the strong Chinese players are finding it difficult to dish out strong performances on a consistent basis and expressed hope that the lean patch of the singles players will end soon.
PV Sindhu produced another impressive show as she rallied to a three-game win over USA's Beiwen Zhang to advance to the women's singles quarterfinals
The Indonesian had defeated Sindhu twice in the last three meetings this year, including one at the Madrid Spain Masters final, though the Indian came into the match with an overall 8-2 head-to-head record.
World number 14 Kidambi Srikanth has also withdrawn from the tournament and is in quarantine due to his close contact with Sai Praneeth, BWF said. Srikanth had returned a negative result on Monday.
The Indians, who were also Asian champions, defeated the current world champions in 43 minutes.
Satwiksairaj Rankireddy and Chirag Shetty enjoyed another memorable 'Evening in Paris', lifting the French Open badminton crown for the second time with a dominating straight-game victory over Chinese Taipei's Lee Jhe-Huei and Yang Po-Hsuan in the men's doubles final in Paris on Sunday.
P V Sindhu has made early exits in as many as seven of the 12 BWF World Tour events this year.
Satwik and Chirag jumped one spot in the latest BWF rankings to regain the fifth place.
Battling an inconsistent form, double Olympic medallist PV Sindhu on Tuesday slipped five places to world number 17 in the latest BWF world rankings.
Sathish Kumar wins men's singles title, Tanisha-Dhruv claim mixed doubles crown at Odisha Masters
Newly-crowned Canada Open champion Lakshya Sen will hope to continue his winning momentum while beginning his campaign at the US Open Super 300 badminton tournament.
PV Sindhu and Lakshya Sen notched up contrasting wins to advance to the semifinals of the Canada Open
A sensational run over the last two weeks has given wings to Ashwini Ponnappa's Olympics dreams, and the ace Indian shuttler now wants to continue her fine run in the upcoming bigger tournaments to stay on course for a trip to Paris.
Earlier, the Badminton Association of India (BAI) had said in an update that Satwik had suffered a groin injury.