Harry Maguire's red card proves costly as Manchester United are held 2-2 by Bournemouth, who equalise late from the penalty spot.
Three late goals from Amad Diallo dragged a below-par Manchester United to an unlikely 3-1 comeback victory over bottom side Southampton.
Manchester United's Harry Maguire struck a late header to seal a thrilling 2-1 Premier League victory over Liverpool on Sunday
Benjamin Sesko came off the bench to score the winner as Manchester United beat Everton 1-0 in the Premier League, strengthening their hold on fourth place under Michael Carrick.
Erik ten Hag's side will face Championship (second-tier) outfit Coventry City in the semis after they upset Wolverhampton Wanderers 3-2 on Saturday.
Carrick faces first test as United boss in Manchester derby showdown
Pictures of the meet were splashed across social media as Indian captain Shubman Gill looked like a happy chappy meeting United captain Bruno Fernandes.
Bournemouth's Eli Junior Kroupi struck late to salvage a point for his side in a 4-4 draw with Manchester United on Monday.
Arsenal maintained a searing pace at the top of the Premier League with a straightforward 2-0 win at Burnley, while Liverpool snapped a dreadful four-match losing run with a 2-0 victory over Aston Villa to climb provisionally to third.
Amad Diallo struck a late equaliser as Manchester United made a mockery of their recent form to hold Premier League leaders Liverpool
Manchester United's season, already their worst in the Premier League, hit a new low with their 1-0 defeat to Spurs in that final in Bilbao that denied them a spot in this season's Champions League.
Manchester United's Patrick Dorgu struck in the first half as Ruben Amorim's side held on for an ugly 1-0 victory over Newcastle United on Friday in the year's only Boxing Day fixture to climb to fifth place in the Premier League standings.
Manchester United missed the chance to go fifth in the Premier League when they were held 1-1 by West Ham United at Old Trafford on Thursday, a result which keeps the visitors in the relegation zone.
Promoted Sunderland, who have defied expectations to stay in the top half of the Premier League table, could be the worst affected with six players going to the tournament, while the likes of Fulham, Manchester United, Burnley and Crystal Palace will also have to make do without some key personnel.
Arsenal maintained control of the Premier League title race as they chiselled out a nervy 2-1 win over London rivals Chelsea to open up a five-point lead at the top of the table on Sunday.
De Ligt's last-gasp equaliser snatches dramatic draw for Man United at Spurs
United are six-times League Cup winners, most recently lifting the trophy in 2022-23 with Ten Hag at the helm.
Arsenal's Arteta wary of old foe Villa
'We appreciate your support all over the world'
The win leaves United in 15th place in the Europa League standings on six points from four games.
Manchester City and Chelsea both secured their Champions League places with victories on the final day of the English Premier League season and Newcastle United joined them despite stumbling to a last-day defeat.
Images from the English Premier League matches on Saturday, August 30.
Manchester City have now won only once in 11 games in all competitions.
Postecoglou moves a step closer to making good on his reputation for securing silverware in his second season at clubs and delivering a first cup for Spurs since they won the League Cup in 2008.
United manager Ruben Amorim's tough start to life at Old Trafford continues though and the Portuguese has now lost eight of the 14 Premier League matches since he took charge.
Images from the Europa League semi-finals second leg between Manchester United and Athletic Bilbao, Tottenham Hotspur and Bodo/Glimt, on Thursday.
Not since 1973-74 have Manchester United lost 12 of their opening 25 games in a top-flight season.
IMAGES from the Premier League matches played on Wednesday.
IMAGES from Premier League matches played on Sunday.
IMAGES from the English Premier League matches played on Sunday.
Images from Sunday's action in the English Premier League.
'I don't have a defence. I'm the boss, I'm the manager and I'm not good enough'
Marcus Rashford and Joshua Zirkzee bagged two goals apiece as Manchester United thumped Everton 4-0 on Sunday in new manager Ruben Amorim's first Premier League match at Old Trafford.
A deflected late strike from Lisandro Martinez earned Manchester United a much-needed 1-0 victory at Fulham in the Premier League on Sunday.
Forward Rasmus Hojlund scored twice to allow Manchester United to come back from a goal down and get a 2-1 win at six-times Czech champions Viktoria Plzen in the Europa League on Thursday.
IMAGES from the Premier League matches played on Sunday.
Manchester United got their pre-season off to a flying start with a 4-0 rout of rivals Liverpool in Thailand on Tuesday, giving new manager Erik ten Hag a big boost in his first match in charge.
Manchester City and Arsenal closed in on Premier League leaders Liverpool with contrasting victories on Saturday as Manchester United's bubble was burst by Fulham.
A weakened Manchester United were beaten 2-1 at home by Leicester City on Tuesday, ending Manchester City's wait to be crowned Premier League champions.
Brazilian Casemiro struck late to send Manchester United into the FA Cup quarter-finals with a 1-0 victory over Nottingham Forest as teenagers Jayden Danns and Lewis Koumas inspired Liverpool to a 3-0 win over Southampton on Wednesday.