Until last season, Manchester United had never lost in the Premier League at Upton Park but the Londoners, who also triumphed at Old Trafford in May, made it two in two seasons with late goals by defenders Anton Ferdinand and Matthew Upson.
Sheffield United finished the season in 18th place with a goal difference of -23, a single goal worse than Wigan, to join already relegated Charlton Athletic and Watford in the second division.
West Ham United humbled holders Manchester United 4-0 on Tuesday to reach the League Cup semi-finals with Old Trafford reject Jonathan Spector scoring twice in the swirling snow at Upton Park.
West Ham United piled more misery on managerless Tottenham Hotspur by coming from behind to book their place in the League Cup semi-finals with a 2-1 win at White Hart Lane and Manchester United also reached the last four on Wednesday.
Manchester City fired the opening shots at the start of a pivotal period in the Premier League title race with a 3-1 victory at bottom club West Ham United on Saturday despite the absence of suspended talisman Carlos Tevez.
Images from the English Premier League matches played on Saturday
Ruud van Nistelrooy will take over on an interim basis.
United are 13th in the Premier League table and following a 1-1 draw with Dutch side Twente Enschede in the first Europa League match, Ten Hag said speculation about his job was inevitable.
Tottenham's task was made all the more difficult two minutes before the interval when forward Son Heung-min was sent off
Argentina host Chile at the Monumental stadium in Buenos Aires on September 5 before facing Colombia five days later in Barranquilla.
Santi Cazorla scored a 94th-minute penalty as sub-par Arsenal beat Southampton on Saturday with Laurent Koscielny's overhead kick having earlier cancelled out Petr Cech's own goal.
Jamie Vardy's record scoring streak ended but LeicesterCity's improbable Premier League title challenge continued with Riyad Mahrez's hat-trick sealing a 3-0 win at SwanseaCity that put them top on Saturday.
Tottenham Hotspur hammered 10-man Aston Villa 4-0 in the Premier League on Sunday thanks to four second-half goals, allowing them to close the gap with their Birmingham rivals to two points in the chase for Champions League football next season.
Images from the English Premier League matches played on Sunday
Manchester United forward Anthony Martial may be rested for Tuesday's Premier League trip to West Ham United to avoid aggravating a hamstring injury, manager Louis van Gaal has said.
Pep Guardiola has apologised to Kalvin Phillips for saying the midfielder was overweight
IMAGES from the EPL matches played on Saturday.
Andy Carroll scored a eight-minute hat-trick as West Ham United's last London derby at Upton Park ended in a barnstorming 3-3 draw with Arsenal on Saturday -- a result that dented both club's respective ambitions.
Tottenham Hotspur and Newcastle United both sealed comeback victories to boost their European qualification hopes.
Leandro Trossard transformed the mood at Arsenal with the winning goal as they recovered from an early setback to beat Tottenham Hotspur 2-1 at home.
Photos from the English Premier League matches played on Sunday
Manchester City won an unprecedented fourth straight English top flight title with a 3-1 win over West Ham United.
Kevin de Bruyne struck twice to inspire Manchester City to a dominant 4-2 win at Crystal Palace on Saturday and move the champions level on points with Liverpool at the top of the Premier League table.
Liverpool climbed to the top of the Premier League table with a 2-1 victory over struggling Wolverhampton Wanderers on Saturday.
Reigning champions City are also involved in a separate independent hearing into the club's alleged breaches of Premier League financial regulations which began in September, with a verdict expected some time before the end of the current season.
Images from the English Premier League matches played on Sunday night.
IMAGES from the Premier League matches played on Saturday
Images from the English Premier League matches played across England on Wednesday.
Newcastle United's clash with AFC Wimbledon was postponed after flooding damaged the Wimbledon pitch on Monday.
A summary of Thursday's action in the Premier League.
The Premier League's bottom two clubs met at Goodison Park and there was more woe for Everton as they bowed out on penalties to Southampton after a 1-1 draw.
Jarrod Bowen and Mohammed Kudus' second-half goals gave West Ham a 2-0 win over Manchester United in the Premier League's early game on Saturday, as the Hammers briefly moved into the top six.
Images from the English Premier League matched played on Wednesday.
A summary of Sunday's action in the English Premier League.
Images from the English Premier League matches played over the weekend.
West Ham United have condemned the behaviour of some of their fans after Fiorentina's Cristiano Biraghi was hit by a cup during the Europa Conference League final.
Ivan Toney, once Brentford's lynchpin in attack, has moved to Al-Ahli for 40 million pounds ($52.50 million).
Liverpool strolled to a 2-0 victory over Brentford, while Newcastle drew 1-1 at Bournemouth.
Liverpool draw Sparta Prague in Europa League last 16
Neither the weather nor the anti-climax of the ceremony taking place the day after the FA Cup final defeat by arch-rivals Manchester United 2-1 could dampen the spirits as flags, bananas and even a blow-up Jack Grealish dummy were held aloft in triumph.
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