The challenge against champions Chlesea on Sunday is for Manchester United to show that they can replicate the confident and businesslike win that City showed a month ago.
A summary of Wednesday's group matches in the UEFA Champions League.
Images from the English Premier League matches played on Sunday.
Chelsea brought a whole new dimension to the Premier League title race when they handed Manchester City their first defeat of the season on Saturday to leave Mohamed Salah-inspired Liverpool as the new leaders.
News of all that's transpired on and off the football field
Manchester City continued their imperious start to the season with a 2-1 win over Swansea City to reach the fourth round of the League Cup on Wednesday but it was a testing night for rivals United who eventually overcame Northampton Town 3-1.
News of all that transpired on and off the football field.
Pep Guardiola drew first blood in his renewed managerial duel with Jose Mourinho as Manchester City deservedly won an absorbing Premier League derby 2-1 against Manchester United at Old Trafford on Saturday.
Not many people talk badly of Pep Guardiola, a sainted figure in football, but Manchester City's manager will find two of his most vocal critics facing him down at Old Trafford on Saturday.
Manchester United eased the pressure on manager Ole Gunnar Solskjaer with a 3-1 win at Everton in the Premier League on Saturday with Bruno Fernandes scoring twice and Edinson Cavani grabbing his first for the club.
Manchester United's Paul Pogba and Henrikh Mkhitaryan scored a goal in each half as their team comfortably outclassed Ajax Amsterdam to win an emotional Europa League final 2-0 and qualify for the group stages of the Champions League.
Romelu Lukaku scored twice to earn Belgium a 2-1 victory over Switzerland in the Nations League on Friday, lifting the mood in the country after a week marred by match-fixing allegations.
Manchester City claimed the win required to finally end Liverpool's relentless attempt to dethrone them as Premier League champions as they hit back from a goal down to crush Brighton and Hove Albion on the south coast on Sunday.
As the black-tinted sports cars carrying Manchester United's millionaire footballers rolled into the club's Carrington complex for the start of pre-season training on Wednesday, no one wound down any windows to discuss the start of life under Jose Mourinho. But there was surely only one topic of conversation when the players began the hard task of proving to the new manager on the pitch that they can forge the sort of future he outlined so eloquently at his news conference the previous day.
I'm not happy with just fighting for fourth, I want to fight for trophies, says manager Jose Mourinho
The Champions League quarter-final between Liverpool and Manchester City is one of the most anticipated games of the season pitting the Premier League's runaway leaders against the top scorers in Europe's elite competition.
Aston Villa were relegated from the Premier League for the first time since it began in 1992 when they suffered their 24th loss of the season in a 1-0 defeat at Old Trafford on Saturday.
'It's very difficult to play football in these circumstances within 48 hours. It's amazing for the fans around the world, everybody has the Premier League, I'm more than happy to do that but it's very hard for the players'
Having beaten Colombia in a tense Round of 18 match at the World Cup England can now look forward to a quarter-final against Sweden with the curse of the shootout lifted.
Bristol City, from English football's second-tier, pulled off a sensation in the League Cup quarter-finals as they knocked out the holders Manchester United 2-1 amid late and wholly improbable drama at their Ashton Gate home on Wednesday.
News of all that's transpired on and off the football field.
Inter Milan's aversion to Europa League football continued with a 3-1 defeat at Sparta Prague, while AS Roma ended a continental hoodoo stretching back seven games with a 4-0 home win over Romanian side FC Astra on Thursday.
A summary of sports events and sports persons, who made news on Thursday
Premier League leaders Manchester City recovered from two goals down to beat Championship side Swansea City 3-2 at the Liberty Stadium on Saturday and progress to the FA Cup semi-finals.
Cristiano Ronaldo scored the 750th goal of his remarkable career in a 3-0 win over Dynamo Kyiv on Wednesday
News of all that's transpired on and off the football field.
Images from the English Premier League matches played on Saturday
Manchester City progressed to the knockout stages of the Champions League from Group F on Tuesday after twice coming from behind to draw 2-2 with Olympique Lyonnais, a team Pep Guardiola hailed as one of the toughest he has ever faced.
News of all that's transpired on and off the football field
Second half goals from Presnel Kimpembe and Kylian Mbappe gave the impressive French side a clear advantage ahead of the return in Paris on March 6.
Images from the English Premier League matches played on Wednesday.
City are 18 points clear of second-placed Liverpool after beating Chelsea 1-0 at the Etihad Stadium on Sunday and need just four wins from their final nine games to be sure of the title.
News of all that's transpired on and off the football field.
IMAGES from the UEFA Champions League quarter-final 2nd leg matches played on Tuesday
News of all that's transpired on and off the football field.
Lionel Messi came off the bench to inspire Barcelona to a 3-1 win over a dogged Leganes side on Sunday, creating one goal and scoring another to keep the Catalans five points clear at the top of La Liga.
Images from the European World Cup qualifiers played on Thursday
Manchester United's troubled season hit a new low on Saturday as Jose Mourinho saw his gamble on introducing a new tactical system backfire with an insipid 3-1 defeat to West Ham United in the Premier League.
IMAGES from Saturday's English Premier League matches.
Images from the Champions League matches played on Wednesday