Tsitsipas was philosophical in defeat.
It was sweet victory for Japan's Miyu Kato as she bagged the mixed doubles crown with Tim Puetz after being disqualied from the women's doubles.
Top seed Novak Djokovic produced a stellar display to sweep aside Croatian Marin Cilic 6-3, 6-4 in the final of the ATP 250 Tel Aviv Open on Sunday and clinch his third title of the season.
Serbia have been drawn in Group B alongside Spain, South Korea and Canada.
Ahead of this season's Wimbledon, here's a look at the prize money.
Djokovic said his son had won his first tournament on the same day he won the Italian Open
Novak Djokovic enjoyed a stress-free return to US competition following a two year absence
Images from the men's singles fourth round matches on Day 8 of the 2023 Australian Open in Melbourne on Monday.
Greece's Tsitsipas battled back from 3-5 down in the third set to eliminate Medvedev with a 6-3, 6-7(11), 7-6(1) win to set up a showdown on Friday with Rublev for the Red Group's other semi-final spot.
Djokovic also had to contend with hecklers during his second-round win, with one fan attracting his ire in the fourth set after repeatedly making noise while he was preparing to serve.
Novak Djokovic's outstanding serving, mighty forehand and all-court defence delivered him a ninth straight win over Stefanos Tsitsipas in their Red Group match.
IMAGES from Day 5 of the US Open, at the USTA Billie Jean King National Tennis Center, Flushing Meadows, New York, on Friday.
Djokovic was deported on the eve of the 2022 Australian Open in January
Novak Djokovic missed two of this year's four Grand Slams due to not being vaccinated against the novel coronavirus but the Serbian said he has no regrets about his decision.
Novak Djokovic overcame a slow start to outclass Nick Kyrgios 4-6, 6-3, 6-4, 6-6 (7) in the final and win his seventh Wimbledon title in London on Sunday.
Russian Daria Kasatkina said she left the French Open with a bitter taste in her mouth after being booed off by the crowd.
Top seed Novak Djokovic set up a blockbuster Wimbledon final against Nick Kyrgios after recovering from a torrid start to overwhelm Britain's Cameron Norrie 2-6, 6-3, 6-2, 6-4 on Friday.
Carlos Alcaraz stayed on course for his fourth title of 2023 by powering into the semi-finals of the Madrid Open.
Djokovic left little doubt that he would also be there trying to win major number 23.
Djokovic has refused to take the vaccine and appears set to miss out on the year's last Grand Slam
'There are a number of unique challenges elite tennis players have to face. The game is gladiatorial in nature with nowhere for players to hide and no team mate or manager to help deflect the pressure.'
IMAGES from all the action on Day 7 of the US Open played at the USTA Billie Jean King Tennis Center at Flushing Meadows in New York on Sunday.
Novak Djokovic produced a stunning performance to thrash Frances Tiafoe in his first match since winning Wimbledon in July to edge Team Europe ahead in the Laver Cup on Saturday.
There is a petition circulating to allow Novak Djokovic to play at the US Open but the Serbian appears likely to miss the entire North American hardcourt swing barring a sudden change in COVID-19 protocols in the United States and Canada.
World No. 1 Novak Djokovic is determined to give it his best shot in Paris to win the elusive Olympic gold medal.
Andy Murray said he is hoping for a "special" final chance to share a court with Roger Federer at next week's Laver Cup in London and possibly team up to play doubles before the Swiss great retires from the sport.
Novak Djokovic, who won Wimbledon to take his major singles titles to 21, has opted not to be vaccinated against COVID-19. He said on Thursday he could not fly to New York for the year's final Grand Slam.
Earlier, title holder Borna Coric beat American Sebastian Korda 7-6 (5), 6-4, while another home hope Taylor Fritz survived a first-set thriller to beat Czech Jiri Lehecka 7-6 (14), 6-2.
The embarrassing sight of empty seats - particularly in the corporate boxes - will linger in the mind after this year's French Open.
The Australian's determination to once again display his talent on the Wimbledon lawns is an illustration of the huge importance the grasscourt Grand Slam has played in his career.
Djokovic said the Spaniard remains his biggest rival.
Djokovic's official website also confirmed his participation in the Dubai tournament.
'There is so much excitement brewing about Wednesday's Alcaraz and Rune quarter-finals showdown -- it could well be a juicy foretaste of things to come.'
Images from Day 3 of the US Open, at Flushing Meadows, New York.
Djokovic must leave Australia after three federal court judges decided unanimously Sunday to uphold the immigration minister's right to cancel Djokovic's visa.
While several top seeds will have their say, a look at some emerging players who could be serious contenders.
At one stage, police deployed pepper spray.
'I would say the first set and the second set was really, really intense and I started to cramp in my arm.'
British wildcard Liam Broady claimed the biggest win of his career and the biggest shock of Wimbledon 2023 when he stunned Norwegian fourth seed Casper Ruud 6-4 3-6 4-6 6-3 6-0 in front of a delirious Centre Court crowd.