13 of the men's seeds fell at the first hurdle -- a Wimbledon record since 32 seeds were introduced in 2001.
French Open champion Gauff is in line for a clash with fellow American Jessica Pegula.
On the anniversary of the day he first walked on to the Roland Garros court 20 years ago, Rafael Nadal returned as a hero to be celebrated by a crowd that has always embraced him as one of their own.
'We both played high level but I stayed so calm and I really enjoyed the battle.'
IMAGES from the French Open at Roland Garros, in Paris, France, on Wednesday.
Three-time champion Novak Djokovic battled past Frenchman Corentin Moutet in a match that lasted more than three hours on Thursday.
He will surpass Roger Federer's record as the oldest No. 1 in ATP Rankings history on Sunday when he will be 36 years and 321 days old.
With two match wins in total in his last four Grand Slams, Tsitsipas has turned to the former coach of Novak Djokovic to turn his fortunes around.
Factbox on Spanish second seed Carlos Alcaraz, who beat Italian world number one Jannik Sinner 4-6, 6-7(4), 6-4, 7-6(3), 7-6(10-2) in the French Open final on Sunday to win his fifth Grand Slam title.
Novak Djokovic may have played at the Madrid Open for the last time after crashing out
Unseeded Alejandro Tabilo beat twice champion Novak Djokovic 6-3, 6-4 in the second round of the Monte Carlo Masters on Wednesday to maintain a remarkable 100 percent record win record over the 24-times major winner.
'One of the things I love about Virat's thought process on the game is, it is always the aggressive option.'
Paris St Germain forward Ousmane Dembele got a roaring welcome usually reserved for tennis champions when he carried the freshly-won Champions League trophy onto centre court on Monday.
Djokovic is the last member of the "Big Four" still standing and the Serb said he wanted to continue giving to the sport.
Teenager Andreeva shows her mettle, Pegula advances at French Open
Struggling Swiatek will open her campaign against Slovakian Rebecca Sramkova.
The French Open is elevating its total purse at Roland Garros to about $63.7 million, an increase of 5.21 percent compared to last year.
Jannik Sinner defeated Carlos Alcaraz in a high-octane final to claim his maiden Wimbledon trophy and fourth Grand Slam crown on Sunday.
'I believe that tennis or every sport needs rivalries. This could be potentially one of them, but there are amazing players coming up.'
Coco Gauff forgot to bring her rackets to the court but reminded her rivals of her French Open title ambitions with a commanding win while Daniil Medvedev lost his composure on a cold and blustery Tuesday as he crashed out in the opening round.
Medvedev says all-conquering Djokovic is the 'greatest'
Sinner faces defending champ Alcaraz in hotly anticipated French Open final
Six-time champion Novak Djokovic has withdrawn from this year's Italian Open, organisers said on Tuesday.
The 19-year-old Czech Jakub Mensik beat his childhood idol Novak Djokovic in the Miami Open final in an upset for the ages on Sunday.
Jannik Sinner's dazzling winning streak ground to a halt ahead of the French Open but the world number one's top-notch return from a three-month doping ban suggests he will be the main challenger to Carlos Alcaraz in Paris.
Carlos Alcaraz heads to Paris for his French Open title defence having laid down a marker with his victory over world number one Jannik Sinner in Rome
Gael Monfils thrilled the Roland Garros crowd with his 12th five-set victory at the French Open on Tuesday before revealing that he does not enjoy having to dig himself out of deep holes at Grand Slams.
'It's a different surface and I've not had much time to get used to this tournament so my expectations aren't that high.'
'Beautiful draw': Retiring Gasquet meets Sinner in French Open swansong
Alexander Zverev will be third seed for the French Open but the 28-year-old German's prospects of winning his first Grand Slam title in Paris are not looking especially bright.
Novak Djokovic is one win away from a 100th career singles title after breezing past Grigor Dimitrov 6-2, 6-3 on Friday to reach the Miami Open final, where he will face either third seed Taylor Fritz or rising Czech Jakub Mensik.
Electronic line calling systems were also affected by the power cut, the ATP said, while spectators shared pictures of dark hallways at the Manzanares Park Tennis Center.
As the spotlight shines on Carlos Alcaraz's title defence and Novak Djokovic's pursuit of a record 25th Grand Slam, a determined group of challengers is quietly preparing to shake up the draw.
Novak Djokovic said working with coach Andy Murray still felt a bit surreal but it offered him the opportunity to finally build a personal relationship with the Scot after their long rivalry on court.
Norway's Casper Ruud won his first Masters 1000 title on Sunday, as he stormed to a 7-5, 3-6, 6-4 victory over fifth seed Jack Draper in the Madrid Open final with a gutsy performance that showcased his clay-court mettle.
'We were the best team in Asia at one point. Today, we are barely in the reckoning for the Davis Cup.' 'Players now, especially this decade, lack perseverance.'
Novak Djokovic fell short in his bid to claim a 100th ATP title following a straight sets defeat by Czech teenager Jakub Mensik in the Miami Open final
Carlos Alcaraz distanced himself from the class-action lawsuit filed by the Professional Tennis Players' Association
Djokovic has spent more than 400 weeks at number one and now sits fifth in the rankings
Djokovic was playing alongside world number one golfer with disabilities Kipp Popert as part of Colin Montgomerie's team which also featured Gareth Bale.