Frenchman Adrian Mannarino also quit at two sets apiece against eight-times champion Roger Federer after sliding over on Centre Court and injuring his knee.
Images from the men's singles Round of 16 matches at the US Open on Monday.
It was an emotional win for Aryna Sabalenka, who missed Wimbledon last month due to a shoulder injury.
World number one Jannik Sinner's bid for a second Grand Slam title continued to gain momentum as he thumped Christopher O'Connell 6-1, 6-4, 6-2 on Saturday to reach the US Open fourth round.
Djokovic spent much of the third-round encounter cruising on auto-pilot
Wimbledon's cancellation due to the COVID-19 pandemic this year will have no major financial impact on British tennis, outgoing All England club Chief Executive Richard Lewis said. The grasscourt Grand Slam was scheduled to start on Monday but was cancelled for the first time since World War Two in April.
Nick Kyrgios could not resist poking his nose at authority and Wimbledon's all-white clothing rules.
Factbox on Novak Djokovic's five Wimbledon titles
Zheng Qinwen became the first Chinese player to win an Olympic tennis singles gold medal when she held off Croatia's Donna Vekic for a 6-2, 6-3 win in a tense final on Saturday.
The 16-year-old backed his aggressive backhand throughout the contest and went on to win 17 of his 23 points at the net to seal victory in 61 minutes.
Serbia's Novak Djokovic beat Italy's Lorenzo Musetti 6-4 6-2 to reach his first Olympic final on Friday and will bid for gold in a blockbuster clash with Carlos Alcaraz.
'Last year I was one point away to the final. I felt competitive last couple of years, so why do I need to change that?'
China's Zheng Qinwen is bidding to become the fourth woman to win Olympic gold and the US Open title in the same year
Images from the men's singles action at the US Open on Sunday.
Defending champion Novak Djokovic tops the draw while new world number one Ash Barty is top seed in the women's singles.
Rafael Nadal has criticised Wimbledon's unique seedings formula, which could hinder his chances of a third title when the tournament starts on Monday.
Sania and Mattek-Sands too had two opportunities to break their rivals but the American fluffed a volley from the net before left-handed Desirae served extremely well to eventually hold.
His Queen's run, plus a quarter-final at the French Open suggest Novaj Djokovic, who will climb back into the world's top 20 on Monday, is ready for a lengthy run at Wimbledon.
Last year's runner-up and seventh seed Ruud will now advance to the semi-finals, where he could face fourth seed Alexander Zverev or 11th seed Alex de Minaur.
Australian John Peers and Finn Henri Kontinen made a small slice of Wimbledon history when they won the first match decided by a tiebreak at 12-12 in the deciding set on Tuesday.
Now both men have made history for their country, leaving a permanent mark on the history books.
India's Ramkumar Ramanathan defeated Argentina's Tomas Martin Etcheverry 6-3, 6-4 in the penultimate round of the qualifying tournament.
'Do me a favour': Andy Murray hits back after legacy questioned
'We have dreamt about this for such a long period of time, we worked hard as a unit for such a long period of time and to see this (the trophy) with us, it feels quite relieved as well.'
He may have entered the semifinal as the underdog, but Jannik Sinner's stunning victory over overwhelming favourite Novak Djokovic left the Melbourne crowd shocked.
Wimbledon organisers will announce the cancellation of the grasscourt Grand Slam this week due to the coronavirus pandemic, German Tennis Federation (DTB) vice-president Dirk Hordorff told Sky Sports. All England Lawn Tennis Club (AELTC) officials earlier said the June 29-July 12 event would not be played behind closed doors and postponement was not without significant risk and difficulty.
The duo made the men's doubles semi-finals at Wimbledon and the final of the US Open in the same season.
Images from the US Open men's singles second round matches, at Flushing Meadows, New York, on Wednesday.
Federer, meanwhile, became the first man to lose a Wimbledon singles final after holding match points since 1948 when John Bromwich failed to convert three of them against Bob Falkenburg.
World number one Novak Djokovic is considering going without a coach after 20 years in professional tennis, the Serb said after receiving the top men's honour at the Laureus awards.
Thirteen months ago, Comaneci was the first person Halep hugged when she clambered up into the stands on Court Philippe Chatrier after she won her first Grand Slam title at the French Open.
Three contenders for the women's singles title at the Australian Open.
India's first and only tennis medal in the history of Olympic Games came way back in 1996, when Leander Paes claimed the singles bronze in Atlanta.
IMAGES from Day 1 of the US Open played Flushing Meadows, New York, United States, on Monday.
After losing the first set, Konta faced three break points in an epic fifth game of the second when she came under enormous pressure.
'I'm very privileged to be in the second week of Wimbledon again. This is genuinely one of my favourite weeks of the year so to be prolonging my stay is a lot of fun but I'm looking forward to the challenge.'
Images from the US Open women's singles second round matches, at Flushing Meadows, New York, on Wednesday.
The 85-ranked Indian lost his first round match 6-2, 3-6, 3-6, 2-6 in two hour and 38 minutes.
The 23-year-old Pole, who also won the Roland Garros title in 2020, said she was fully aware that perfectionism was a double-edged sword.
An inspired Halep took full advantage of an error-strewn display by seven-time champion Williams to become the first Romanian to win the Wimbledon title.
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