A slip-up could spell the end of their hopes of making the next round in the Champions League.
Bayer Leverkusen struck three times in a decisive 15-minute spell to set up a 4-2 win over Mainz and move back to the top of the Bundesliga on Saturday.
Luis Garcia scored twice in a 3-1 victory in the second leg of the Champions League pre-quarter-finals.
A last-gasp goal from Hertha Berlin's Adrian Ramos denied Bayer Leverkusen the chance to go six points clear at the top of the Bundesliga on Friday after a 2-2 draw.
Bayer Leverkusen face what looks to be the near-impossible task of putting three goals past Barcelona at the Nou Camp on Wednesday and to do so they will need to dethrone the undisputed passing kings of Europe.
The other semi-final will see an Italian side, Milan or Roma, come up against Bayer Leverkusen or West Ham.
Osasuna beat Bayer Leverkusen 1-0 at home in the UEFA Cup on Thursday to earn themselves an emphatic 4-0 win on aggregate and set up an all-Spanish tie against holders Sevilla in the semi-finals.
Leverkusen finally subdued Besiktas with two goals in the last 13 minutes to secure the 2-1 win they needed to overhaul their Turkish opponents for third place in Group B.
Bayer Leverkusen squandered a chance to go two points clear at the top of the Bundesliga on Sunday when they conceded an injury-time equaliser in a 2-2 draw at Werder Bremen.
Bayern Munich continued their winning run on Saturday by beating fading champions VfL Wolfsburg 3-1 to draw level on points with Bayer Leverkusen at the top of the Bundesliga.
Manchester City came from behind to beat Club Brugge 3-1 and secure their place in the Champions League playoffs
Schalke 04 carried some of their Champions League momentum into the Bundesliga on Sunday, beating Freiburg 2-0 to bounce back after a string of erratic results.
IMAGES from the UEFA Champions League matches played on Wednesday.
Bayer Leverkusen beat a second-string Bayern Munich 2-0 on Saturday to move up to third in the Bundesliga and get back on course for an automatic Champions League spot with three matches left in the season.
Manchester City's spending of more than 180 million pounds ($223.58 million) was the second-biggest outlay ever worldwide by a club in the January transfer window.
Inter Milan and Bayer Leverkusen cruised into the Europa League knockout stage with emphatic wins on Thursday but holders Atletico Madrid and former winners Liverpool suffered surprise defeats.
Bayern Munich retained their two-point lead at the top of the Bundesliga with a nervous 3-1 victory against Mainz 05 on Saturday as champions Borussia Dortmund kept up the chase with a 3-0 win over Bayer Leverkusen.
It is a mark of how far Tottenham Hotspur have come that they start as favourites to win what could be a pivotal Champions League Group E fixture away to Bayer Leverkusen on Tuesday despite the absence of key defender Toby Alderweireld.
A round-up of Saturday's action in LaLiga, Ligue 1, Serie A and Bundesliga.
Bayern Munich extended their lead at the top of the Bundesliga to two points despite drawing 1-1 at Bayer Leverkusen on Saturday, keeping their dreams of winning a treble on track.
A summary of Wednesday's action in the UEFA Champions League Knock-out phase play-offs.
Liverpool were drawn on Thursday to face champions Real Madrid when they return to the Champions League, which has been expanded to a 36-team league format.
Lionel Messi, at his breathtaking best, tore Bayer Leverkusen apart with a record five-goal Champions League haul on Wednesday as Barcelona swept into the quarter-finals 7-1 on the night and 10-2 on aggregate. The Argentine World Player of the Year became the first player to score five in a Champions League match.
Bayer Leverkusen beat Freiburg 3-2 to edge closer to a first ever Bundesliga title.
Holders Barcelona will play Bayer Leverkusen, a team famous for fading in the final straight, while their arch-rivals Real Madrid face a trip to icy Moscow in the Champions League round of 16 following the draw on Friday. Bayern Munich, whose Allianz Arena will host the final, take on FC Basel, the underdogs who spectacularly ousted Manchester United, in another of the top ties.
Bayer Leverkusen rallied with three second-half goals to beat AS Roma 3-1 in a Champions League Group B match on Tuesday.
La Liga leaders Real Madrid cruised to a 4-0 home win over relegation-threatened Celta Vigo on Sunday to restore their seven-point lead at the top of the table with a dominant display.
Rishabh Pant has been nominated for the prestigious Laureus World Comeback of the Year Award.
Real Madrid's Cristiano Ronaldo set a Champions League group phase scoring record on Tuesday as Bayer Leverkusen and Olympiakos Piraeus reached the last 16 and snow forced Galatasaray's match with Juventus to be abandoned.
Barcelona thrashed Real Betis 5-1 on Wednesday to book their spot in the Copa del Rey quarter-finals.
Paris St. Germain's unbeaten start to their Ligue 1 season continued on Friday with a comfortable 3-1 win over Rennes at the Parc des Princes that saw Bradley Barcola score twice to keep them top of the standings.
Thomas Tuchel is regarded as one of the most progressive tacticians in the game, albeit a coach not afraid to ruffle feathers.
Images from the Euro 2024 quarter-final between Spain and Germany, at Stuttgart Arena, Germany, on Friday.
Late Tchouameni header gives Real Madrid 2-1 Las Palmas win and top spot
Germany midfielder Aleksandar Pavlovic will miss Euro 2024 with an illness and coach Julian Nagelsmann has called up Emre Can as his replacement
Liverpool draw Sparta Prague in Europa League last 16
A Dani Carvajal strike in the ninth-minute of stoppage time rescued Real Madrid, earning them a 3-2 comeback win at home against bottom side Almeria on Sunday in a frantic LaLiga tussle that was marked by VAR controversy.
Barcelona suffered a shock 1-0 LaLiga defeat at Real Sociedad on Sunday that ended their seven-match winning streak in all competitions.
Paris St Germain closed out the year on a high as they maintained their five-point advantage at the top of the table.
Roundup of the matches being held across major football leagues in Europe
