The commanding scoreline in the cross-town London derby came despite Chelsea's midfield talisman Cole Palmer being ruled out after he felt discomfort on the pitch during the pre-match warmup.
Arsenal have signed Swedish striker Viktor Gyokeres from Sporting on a five-year deal, the Premier League club said on Saturday.
It took 10 Premier League games for the first cracks to appear in Manchester City's facade last season, but Pep Guardiola got a much earlier reminder of his side's fall from grace on Saturday in another defeat to Tottenham Hotspur.
Brighton midfielder James Milner, who made his Premier League debut in 2002 at age 16, passed Ryan Giggs into second in all-time league appearances on Monday with 633 matches. He needs 20 more to equal Gareth Barry's record.
Arsenal's Calafiori secures 1-0 win at Manchester United; Crystal Palace hold Chelsea to 0-0 draw.
Barcelona's electric 18-year-old winger Lamine Yamal has been handed the famous number 10 shirt previously worn by club icon Lionel Messi.
Phil Foden struck twice as Manchester City stepped up their bid for a fourth Premier League crown in a row with a ruthless 4-0 victory at Brighton & Hove Albion on Thursday.
IMAGES from the Premier League matches played on Wednesday.
IMAGES from the Premier League matches played in England on Sunday.
IMAGES from the English Premier League matches played on Saturday.
IMAGES from Premier League matches played on Sunday.
Arsenal closed the gap on leaders Liverpool with a 2-1 Premier League victory at Nottingham Forest
Images from Saturday's FA Cup quarter-finals.
A round-up of Saturday's action in the Premier League.
Champions Manchester City's 12-match winning streak in the Premier League came to an end as Julio Enciso's stunner earned sixth-placed Brighton and Hove Albion a 1-1 draw.
An early penalty by Alexis Mac Allister and a Darwin Nunez brace helped Liverpool to thrash Sparta Prague 5-1.
A round-up of Saturday's action in the Premier League.
A round-up of Tuesday's action in the Premier League.
Welbeck extra-time winner sends Brighton into quarters
Sunderland stun Sheffield United in playoff to return to Premier League
IMAGES from the Premier League match played between Brighton & Hove Albion and Manchester United on Thursday.
A round-up of Saturday's action in the Premier League.
Three late goals from Amad Diallo dragged a below-par Manchester United to an unlikely 3-1 comeback victory over bottom side Southampton.
Some lament the FA Cup having lost much of its romance in recent years, in the face of obsession with the Premier League, but this tie had it in bucket loads.
Arsenal moved up to second in the Premier League and within six points of Liverpool after a largely trouble-free, if slightly pedestrian, 1-0 win at home to struggling Ipswich Town on a chilly night in north London on Friday.
Champions Manchester City could only muster a 2-2 Premier League draw with Brighton & Hove Albion on Saturday.
IMAGES from the Premier League matches played on Sunday
A round-up of Saturday's action in the Premier League.
A summary of Saturday's action in the Premier League.
Images from Thursday's action in the Premier League.
Rashford is not my player at the moment but every player that performs well on loan is good news for my club.
Images from Saturday's action in the Premier League.
IMAGES from the English Premier League matches played on Saturday.
Aashita Sood and Mayank Agarwal are enjoying their 20-day break ahead of the Test series against England.
Nottingham Forest reached the FA Cup quarter-finals as they beat fellow Premier League club Ipswich Town on penalties after the City Ground clash ended 1-1 after extra time on Monday.
Manchester United languish 14th in the standings on 19 points, their worst placing to end a calendar year since they were 15th in 1989.
Norwich City winger Borja Sainz has been suspended for six matches and fined 12,000 pounds ($14,749) for spitting at an opponent.
It is the first time since 1989-90 that Manchester United have lost 10 of their first 22 games of the league season.
Ronaldo answered his critics five minutes after halftime with a superb finish
Brazil, who are fifth in the CONMEBOL table with 18 points from 12 games, host Colombia on March 21 and visit Argentina five days later in a match that could see Neymar come up against former Barcelona and Paris St Germain teammate Lionel Messi.