Erik ten Hag's side, featuring several players who played in the World Cup in Qatar, could have doubled their lead when Anthony Martial's shot was well saved by Burnley goalkeeper Bailey Peacock-Farrell.
The defeat halted Brighton's impressive three-game winning streak which included a 4-1 win over Chelsea and a 3-1 victory at Arsenal in the League Cup on Wednesday.
English Premier League leaders Manchester City and Chelsea slugged out a magnificent 4-4 draw at Stamford Bridge.
Man City set to release skipper Gundogan and Mendy
Images from the English Premier League matches played on Saturday night.
IMAGES from the EPL matches played on Wednesday.
Arsenal returned to the top of the Premier League with a comfortable 2-0 victory over relegation-threatened Luton Town
The Englishman lasted 31 games, winning only 12, before the owners pulled the trigger.
Tottenham Hotspur and Newcastle United both sealed comeback victories to boost their European qualification hopes.
A ninth successive win in all competitions for United was celebrated with real vigour, as they moved to within a point of City in second, giving Arsenal the chance to go eight points clear at the top of the standings with a win over Tottenham Hotspur on Sunday.
Mohamed Salah scored a late equaliser from a penalty kick as Liverpool escaped Old Trafford with a single point in a 2-2 draw with Manchester United to climb to even on points with Premier League leaders Arsenal.
Brazilian Casemiro struck late to send Manchester United into the FA Cup quarter-finals with a 1-0 victory over Nottingham Forest as teenagers Jayden Danns and Lewis Koumas inspired Liverpool to a 3-0 win over Southampton on Wednesday.
Antony will not immediately return to Manchester United while the Brazil striker addresses assault allegations against him, the Premier League club said on Sunday.
Third-placed Aston Villa are the surprise package of the season and Unai Emery's side face relegation-threatened Burnley while fifth-placed Spurs host a resurgent Bournemouth who have 19 points from their last seven games.
Chelsea came from behind to beat Crystal Palace 3-1 thanks to added time goals from Conor Gallagher and Enzo Fernandez.
IMAGES from the EPL matches played on Saturday
IMAGES from the English Premier League matches played on Sunday
Images from Saturday's action in the Premier League.
Manchester City climbed back into the Premier League's top four as second-half goals by Phil Foden, Julian Alvarez and Bernardo Silva sealed a comeback 3-1 victory at Everton on Wednesday.
IMAGES from the English Premier League matches played on Tuesday.
Manchester City roared back to the top of the Premier League with a 6-1 thrashing of Bournemouth after Manchester United steadied the ship
IMAGES from the Premier League matches played on Wednesday.
Manchester City were confirmed as English Premier League champions for the fifth time in six seasons on Saturday without even having to kick a ball.
A round-up of Saturday's action in the Premier League.
A round-up of Saturday's action in the Premier League.
IMAGES from the English Premier League matches played on Sunday.
Images from the English Premier League matches played over the weekend.
A round-up of Saturday's action in the Premier League.
Images from Saturday's action in the Premier League.
IMAGES from the English Premier League matches played on Wednesday.
Images from the English Premier League matches played on Saturday.
IMAGES from English Premier League matches played on Sunday.
Images from the English Premier League matches played on Saturday
Bukayo Saka scored either side of halftime as Arsenal crushed second-bottom Burnley 5-0.
Champions Manchester City slipped to a shock first Premier League defeat of the season at Wolverhampton Wanderers on Saturday, while Manchester United's campaign of woe continued with a loss to Crystal Palace.
Liverpool overcame an early scare and came from a goal down to claim a 3-1 win at Austria's LASK Linz.
IMAGES from the English Premier League matches played on Saturday
IMAGES from Saturday's action in the English Premier League.
Images from the English Premier League matches played on Saturday.
A summary of Saturday's action in the Premier League.
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