Arsenal, who had 23 shots to Newcastle's seven, piled on the pressure late on to try to reduce the deficit but Newcastle manned the barricades to take a healthy lead to St James' Park.
IMAGES from the South American World Cup qualifiers played on Tuesday.
Brazil return to winning ways with dreary win over Ecuador in their World Cup qualifiers.
Michael Olise scored a stoppage-time penalty as Crystal Palace clawed back from two goals down to draw 2-2 with Manchester City in the Premier League at the Etihad Stadium on Saturday.
Manchester United were humbled 3-0 at home by Newcastle United in the League Cup fourth round
Uruguay and Ecuador secured their spots at the World Cup, joining Brazil and Argentina as qualifiers from the South America
Jarrod Bowen and Mohammed Kudus' second-half goals gave West Ham a 2-0 win over Manchester United in the Premier League's early game on Saturday, as the Hammers briefly moved into the top six.
IMAGES from Saturday's action in the English Premier League.
Cavani netted an opportunist 71st-minute equaliser after Allan Saint-Maximin gave the home side a seventh-minute lead with a fine individual effort, side-stepping two markers before he fired past De Gea.
Darwin Nunez came off the bench to score twice as Liverpool snatched a sensational 2-1 Premier League win at Newcastle United on Sunday.
Monday's resumption was also a chance for those jostling at the top of the table to lay down a marker and for the strugglers to enjoy a fresh start.
A round-up of Wednesday's action in the UEFA Champions League
Nicolas Gonzalez equalised for Argentina four minutes before half-time when he bulleted a header home from a Giovani Lo Celso corner kick.
Images from the UEFA Champions League matches played on Tuesday night.
IMAGES from EPL matches played on Thursday.
Chelsea paid a heavy price for a 3-2 defeat at West Ham United as first Liverpool, then Manchester City, leapfrogged them in the English Premier League title race on Saturday, with City ending the day on top for the first time this season.
A round-up of the action in the English Premier League on Monday.
CR7 started the game against the Toons in his second debut at Old Trafford.
IMAGES from the English Premier League matches played on Wednesday.
Spending falls for first time since 2012
IMAGES from the English Premier League matches played on Saturday.
Arsenal's best chance to equalise came from a Granit Xhaka free kick which looked destined for the top corner until the Gunner's former keeper Emiliano Martinez at full stretch pushed it around the post with a fingertip save.
IMAGES from the English Premier League matches played on Sunday
IMAGES from the EPL matches played on Saturday.
IMAGES from the English Premier League matches played on Saturday.
IMAGES from the EPL matches played on Saturday
Manchester City moved 13 points clear at the top of the English Premier League table after a 2-1 win over West Ham United on Saturday - their 20th straight win in all competitions.
The Gunners' only league defeat of the campaign was in September away to one of England's traditional top-six clubs, Manchester United, drawing criticism that their strong start to the season was based on wins against lesser opposition.
The United States beat Paraguay 1-0 and advanced to the quarter-finals of the Copa America as Group A winners on Saturday after Costa Rica stunned already-qualified Colombia 3-2.
IMAGES from the EPL match played between Arsenal and Newcastle on Monday
IMAGES from the EPL matches played on Sunday.
IMAGES from EPL matches played on Sunday.
A summary of Saturday's action in the Premier League.
A round-up of Saturday's action in the Premier League.
Eight wins and a draw in their last nine games had seen Leicester emerge as the closest pursuers of runaway leaders Liverpool but they went down 3-1 at the Etihad despite taking an early lead through Jamie Vardy. Images from the English Premier League matches played on Saturday.
Images from the English Premier League matches played on Saturday.
Argentina captain Lionel Messi pulled his side level in the 57th minute after a handball by Paraguay's Ivan Peris which no-one on the pitch appealed for but was spotted by a VAR review.
Images from Sunday's action in the Premier League.
But for third-placed Spurs, who trail leaders Manchester City and Liverpool by five points, this may prove to be a loss that leaves them with too much ground to make up.
Lacazette fired the Gunners ahead in the eighth minute after poor defending by the home side before new signing Gabriel made it 2-0 in the 49th and Aubameyang put the icing on the cake with a superb shot into the top corner.
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