Paris St Germain overcame a two-goal deficit and a horror start to beat 10-man Monaco 3-2 in the first leg of their Champions League knockout round playoff tie.
Mbappe fires Real Madrid to the summit, Bayern lose at home and Dortmund stay in the title hunt.
Harry Kane scored his 36th goal of the season but Bayern Munich let a second-half lead slip to draw 2-2 with Hamburg SV.
Bayern Munich, helped by two record-breaking VfL Wolfsburg own goals and two from Michael Olise, demolished the visitors 8-1 in the Bundesliga on Sunday to extend their lead at the top, as the league resumed from its winter break.
Championship side Oxford United beat League Two's MK Dons on penalties after their match ended 1-1, while a couple of League One teams moved on, with Wigan Athletic beating Championship side Preston North End 1-0, and Port Vale defeating League Two's Fleetwood Town 1-0.
IMAGES from the UEFA Champions League matches played on Tuesday
Images from the EPL matches played on Saturday.
IMAGES from the UEFA Champions League matches played on Wednesday.
'The only thing I can do is on the pitch -- to give my all. I won't always be technically perfect, but I will always give 100% for the team.'
Stuttgart stumble to 1-1 against Union, miss out on top three
Bayern Munich, helped by two record-breaking VfL Wolfsburg own goals and two from man-of-the-match Michael Olise, demolished the visitors 8-1 in the Bundesliga on Sunday.
Real Madrid ended a turbulent week with a 2-0 LaLiga win over lowly Levante on Saturday courtesy of second-half goals from Kylian Mbappe and Raul Asencio.
German club Borussia Dortmund said all members of the professional squad and staff tested negative during the first series of coronavirus test adding that "further tests will follow" to ensure the largest possible degree of certainty.
A summary of Wednesday's action in the Champions League quarter-finals first leg.
Inter edge Genoa to go top
IMAGES from matches played across European leagues on Saturday
Recently-retired Indian table tennis great A Sharath Kamal has given himself 11 years to produce the country's first Olympic medallist in the racket sport and German football club Borussia Dortmund could end up being his unlikely ally in pursuit of this path-breaking dream.
Images from the Club World Cup match between Borussia Dortmund and Mamelodi Sundowns at TQL Stadium, Cincinnati, Ohio, on Saturday.
A round-up of Tuesday's action in the UEFA Champions League.
Liverpool shrugged off the absence of Mohamed Salah as midfielder Dominik Szoboszlai scored an 88th-minute penalty to give them a 1-0 Champions League win at Inter Milan.
Manchester City's Erling Haaland came back to haunt Borussia Dortmund with a clinical finish against his former team, while Phil Foden bagged a brilliant brace as the hosts cruised to a 4-1 win in the Champions League on Wednesday to climb to fourth.
The 31-year-old, who has won eight Olympic gold medals in his illustrious career that ended last year, joined the Bundesliga side Borussia Dortmund for a training session on Thursday.
Manchester City's Erling Haaland extended his remarkable scoring streak to 12 straight matches as his side recorded a comfortable 2-0 victory at Villarreal in the Champions League on Tuesday.
Images from the Club World Cup quarter-finals between Paris St Germain-Bayern Munich and Real Madrid-Dortmund.
The 28-year old suspect, a dual German and Russian national identified as Sergei V., had bought options on the day of the attack entitling him to sell shares in Borussia Dortmund at a pre-determined price.
German police arrested a man on Friday who is suspected of planting explosives targeting the bus of soccer team Borussia Dortmund last week, the office of the German federal chief prosecutor said.
A summary of Wednesday's action in the UEFA Champions League.
Mouth-watering matches lined up as PSG to face Bayern and Barcelona in Champions League opening stage.
Kylian Mbappe scored twice from the penalty spot as Real Madrid fought back from a goal down to beat Olympique de Marseille 2-1 in their opening match of the Champions League group stage, at the Santiago Bernabeu, Madrid, on Tuesday.
Real Madrid hit their stride at the Club World Cup on Tuesday, edging Juventus 1-0 to reach the quarter-finals thanks to a second-half strike from academy graduate Gonzalo Garcia.
Borussia Dortmund playmaker Ilkay Guendogan, who was set to leave the German club this summer, could stay on under new coach Thomas Tuchel, his agent said on Tuesday.
IMAGES from the UEFA Champions League matches played on Wednesday
At least one person has been injured by an explosion on the bus taking the Borussia Dortmund soccer team to their UEFA Champions League quarter-final first-leg match against Monaco in Dortmund on Tuesday.
A round-up of Tuesday's Champions League quarter-finals second leg between Barcelona and Dortmund, Aston Villa and Paris St Germain.
Arsenal's Calafiori secures 1-0 win at Manchester United; Crystal Palace hold Chelsea to 0-0 draw.
Three goals in eight first-half minutes sent the Mexican side on their way to victory, with stunning long-range strikes from Nelson Deossa and Jesus Corona coming either side of German Berterame's cool finish.
Juergen Klopp will leave Borussia Dortmund at the end of the season after a seven-year reign as coach which delivered two Bundesliga titles and a Champions League final.
Borussia Dortmund defenders Waldemar Anton and Almugera Kabar are doubtful for Friday's Bundesliga game against Bayer Leverkusen due to illness, coach Nuri Sahin said.
A summary of Saturday's action in LaLiga, Bundesliga and Serie A.
Real Madrid will play local rivals Atletico Madrid while Bayern Munich were drawn against Bundesliga title challengers Bayer Leverkusen on Friday.