The 16-year-old backed his aggressive backhand throughout the contest and went on to win 17 of his 23 points at the net to seal victory in 61 minutes.
Jelena Ostapenko became only the sixth female Grand Slam champion to lose in the opening round of their title defence on Sunday when she lost to Kateryna Kozlova at the French Open.
Form guide for American Serena Williams ahead of Thursday's US Open semi-final clash against Latvia's Anastasija Sevastova:
After a 48-minute battering at the hands of Serena Williams on Wimbledon's Centre Court on Thursday, the last words Elena Vesnina probably wanted to hear were 'see you later'.
Big-serving Isner reaches Montreal second round
The Australian fell to the floor in celebration after clinching the victory, before sticking a finger behind his ear and asking the raucous crowd to cheer louder.
De Minaur, 20, went the entire tournament without facing a break point, and the Australian fittingly clinched victory with a deft serve-and-volley backhand winner.
Holder Serena Williams survived her toughest challenge yet at this year's French Open as she battled into the fourth round with a 6-4, 7-6(10) win over Frenchwoman Kristina Mladenovic in a rain-disrupted match on Saturday.
A rampaging Madison Keys completed an American sweep of the US Open women's quarter-finals on Wednesday, dismissing Estonia's Kaia Kanepi 6-3, 6-3 to guarantee an American champion at the year's final Grand Slam.
Norma Godinho has just about caught her breath after all the action at SW19 on Super Sunday. Here are Norma's memorable moments from this year's Wimbledon.
Serena Williams said it was a 'great feeling' to surpass Steffi Graf as the most prolific grand slam champion of the open era at the Australian Open on Saturday and was not prepared to put a number on the haul of titles she might end up with.
Maria Sharapova will be back in the US Open spotlight on Wednesday hoping she can come up with a winning encore to her electrifying first round victory over second seed Simona Halep.
India's Leander Paes and his German partner Alexander Zverev went down to the Spanish duo of Feliciano Lopez and Marc Lopez in a men's doubles first round match to bow out of the Cincinnati Open.
It was the Russian's first competitive match since she withdrew from the St Petersburg Open in January.
Could French Open champion Jelena Ostapenko serve up another shock at Wimbledon this year? Or will world number one Angelique Kerber get her season back on track at Wimbledon?
Virushka's wedding was, of course, the biggest Indiansports shaadi of the year, but other athletes too tied the knot this year.
Rafael Nadal rallied from a set down to ease past Fabio Fognini 4-6, 6-1, 6-2 in the Italian Open quarter-finals on Friday and set up a mouth-watering clash against long-time adversary Novak Djokovic for a place in Sunday's final. Djokovic plotted a similar path to the Spanish clay-court king when the Serb lost the first set against Japan's Kei Nishikori before recovering to win 2-6, 6-1, 6-3 and seal an open-era record 51st career meeting against Nadal.
Reigning champions Novak Djokovic and Serena Williams have been named top seeds for the Australian Open starting on Monday.
Shares in the Beaverton, Oregon-based Nike Inc fell more than 2 percent after Kaepernick posted a black-and-white close-up of himself on Instagram on Monday featuring the Nike logo and "Just do it" slogan.
Novak Djokovic and Serena Williams are top seeds at the major starting Monday
Images from the action on Day 2 at the Australian Open.
Multiple Grand Slam winner Martina Navratilova questioned the "silence" of the International Tennis Federation after one of its members described world number one Serena Williams and older sister Venus as "brothers".
Take the poll and tell us which Hollywood celeb pulled off Indian wear better.
World No 2 Rafael Nadal sailed into the quarter-finals of the China Open, his first tournament in 13 weeks, with a 6-3, 6-4 win over German qualifier Peter Gojowczyk on Thursday.
Top seeds Novak Djokovic and Serena Williams face challenging early tests at the US Open following Friday's draws for the year's last Grand Slam starting on Monday.
Top seeded Ash Barty overcame a slow start to defeat Maria Sharapova 6-4 6-1, while Simona Halep battled past Ekaterina Alexandrova 3-6 7-5 6-4 in the second round of the Cincinnati Masters on Wednesday.
IMAGES from Day 6 of the French Open, at Roland Garros, on Friday.
Images from Sunday's action at the Australian Open in Melbourne.
A Champagne cork popped somewhere on Centre Court four games into Serena Williams's Wimbledon semi-final and while it was a tad premature, her 6-2 6-0 thrashing of Elena Vesnina suggested she could celebrating something special come Saturday. The top-seeded American will be taking nothing for granted, having seen her bid to match Steffi Graf's modern era record of grand slam titles stuck one short on 21 for a year, but it was a menacing show of strength, albeit against an overawed opponent.
Relentless schedule taking toll on big-name tennis players.
Maria Sharapova's contentious and captivating US Open run came to an end on Sunday when Latvia's Anastasija Sevastova beat her 5-7, 6-4, 6-2 to reach the Flushing Meadows quarter-finals.
Photos from the US Open matches played on Monday
An Australian Open electrified by the revivals of seasoned champions will bathe in the warm glow of nostalgia on Saturday when the Williams sisters contest the women's final at Rod Laver Arena.
Rafael Nadal swept into the quarter-finals of the Italian Open on Thursday with a ruthless 6-4, 6-1 victory over Canadian teenager Denis Shapovalov. The top seed, who will reclaim the world number one ranking from Roger Federer if he wins his eighth title in Rome, turned in a near-flawless performance, losing only five service points as he honed in on victory in an hour and 22 minutes.
It was Kristyna's first win over a top-five ranked player and she will go on to play fellow Czech Barbora Strycova in the quarter-finals.
The Russian five-times Grand Slam champion struggled for rhythm initially on the low-bouncing grasscourt at the Mallorca Open but picked up the pace to beat Viktoria Kuzmova 7-6(8), 6-0.
A summary of sports events and persons who made news on Sunday
The signs that things were going horribly wrong for Roger Federer were laid bare at Roland Garros.
List of Australian Open women's singles champions since the event began in 1922 (Australian unless stated):
Tournament favourite Novak Djokovic beat Finnish veteran Jarkko Nieminen 6-2, 7-5, 6-2 on Tuesday, kicking off his quest for a first ever Paris trophy to add to his eight other Grand Slams.
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