The following is a timeline charting her rise to the top of the women's game:
Serena Williams signalled her intention to retire this month, saying she was "evolving away from tennis" but never confirming the US Open as her final event.
While her career has featured a number of highs -- she has won two doubles Grand Slam titles and 11 WTA titles, including the Cincinnati Masters -- Garcia said she has become fixated on what she sees as her failures.
Serena Williams was included on the entry list for the US Open on Wednesday along with fellow former champion Novak Djokovic, who will not be able to compete due to his refusal to be vaccinated against COVID-19.
Serena Williams said her five-episode documentary series 'Being Serena' is a tribute to all the women who have gotten back to work after becoming a mother.
Serena Williams credited Tiger Woods on Wednesday as one of the main reasons she was still playing tennis.
Sania Mirza in her tribute to Serena wrote how the all-time great women's singles tennis player inspired her.
The defeat ended Williams's bid for a record-equalling 24th Grand Slam title.
Williams has just one professional tournament remaining before she drops the curtain on her historic career
Serena and daughter Alexis Olympia croon to 'Belle' from the classic hit 'Beauty and the Beast'.
'Meghan Markle, my selfless friend, lives her life -- and leads by example -- with empathy and compassion'
Serena Williams survived another scare to beat older sister Venus 3-6, 6-3, 6-4 on Thursday in the latest instalment of their reluctant on-court sibling rivalry to reach the quarter-finals of the inaugural Top Seed Open in Lexington, Kentucky.
Madison Keys, 29, is the fourth-oldest first-time Grand Slam champion in the professional era.
Aryna Sabalenka will battle American 19th seed Madison Keys in the final on Saturday looking to become the first woman since Martina Hingis from 1997-99 to win the Australian Open title three times in a row.
The five time US Open champion was given the loudest cheer at the Arthur Ashe stadium.
Four-time Grand Slam champion Naomi Osaka's name appeared on the singles entry list for Wimbledon released by the organisers on Friday but veterans Roger Federer and the Williams sisters were not included.
Opportunity knocks for Serena Williams on the grass courts of Wimbledon next week when she faces a diminished field on her best surface at the famous All England Club.
Defending champion Jannik Sinner dismissed eighth seed Alex de Minaur 6-3, 6-2, 6-1 to reach the Australian Open semi-finals and extend the country's decades-long wait for another homegrown singles winner at the Grand Slam on Wednesday.
Serena Williams needs to be creative and add variety to her game if the 39-year-old American wants to tame the current power-hitters on clay, seven-time Grand Slam singles winner Mats Wilander said ahead of this week's French Open.
Williams had signalled her intention to retire in a Vogue article in early August, saying she was "evolving away from tennis" but never confirming the U.S. Open as her final event.
Tennis great Serena Williams limped out of Wimbledon in tears on Tuesday after her latest bid for a record-equalling 24th Grand Slam singles crown ended in injury.
'I'm terrible at goodbyes, the world's worst'
Aryna Sabalenka is the red-hot favourite at Melbourne Park, where another victory would give her a fourth major title and widen the gap in the rankings to Poland's Iga Swiatek and Coco Gauff of the United States.
Serena Williams voiced concern for fellow tennis player Peng Shuai, who has not been seen publicly since she accused a former vice-premier of China, Zhang Gaoli, of sexual assault.
Serena Williams could easily walk off the court and into the broadcast booth if she wants to, pocketing a handsome paycheck and boosting ratings for a sport that is losing star power, those in the business say.
American sporting legends including Serena Williams, Michael Phelps and Nastia Liukin turned out witness Simone Biles go for a fifth Olympic gold medal on Tuesday as Biles-mania continued to grip Paris.
In the clash of legends, Roger Federer got the better of Serena Williams in their historic clash in the mixed doubles at the Hopman Cup in Perth on Tuesday.
Serena Williams said she would have faced far harsher punishment had she engaged in similar behavior to Zverev
Venus Williams will miss the upcoming US Open due to an injury, becoming the third U.S. female after her sister Serena and Sofia Kenin to announce on Wednesday they would not take part in the final Grand Slam tournament of the year.
Serena Williams can't stop twinning with her daughter and the Internet is simply loving it!
Osaka will play Jennifer Brady for the title.
Serena Williams creates ripples with her latest outfit.
Three-times winner Serena Williams moved into the Toronto Open second round after beating Spain's Nuria Parrizas Diaz on Monday
A summary of Friday's action at the US Open.
Sofia Kenin said that the experience at Roland Garros changed her career trajectory.
Williams and Hamilton have pledged an estimated 10 million pounds ($13.06 million) each to the bid.
Serena Williams has defeated her compatriot in four straight matches since a defeat in the quarter-finals of the 2013 Australian Open.
Like mother, like daughter! The tennis champ shared a sweet twinning photo with her daughter.
Ohanian married tennis star Serena Williams in 2017.
