With Australia's number one Alex De Minaur opting out of the tie in Quito, the 28-times champions crashed out when Rinky Hijikata and Jordan Thompson were beaten 7-6(5) 6-4 by Gonzalo Escobar and Diego Hidalgo in the decisive doubles rubber.
Novak Djokovic fights past Aleksandar Kovacevic to reach the last 16 at Indian Wells Open, setting up a clash with defending champion Jack Draper.
Jack Draper stunned Novak Djokovic in a deciding-set tie-break while Carlos Alcaraz extended his winning streak to reach the quarter-finals of the Indian Wells Open. Iga Swiatek, Jessica Pegula and Elena Rybakina also advanced.
IMAGES from the Australian Open matches played at Melbourne Park in Melbourne on Thursday.
Julian Cash and Lloyd Glasspool capped their dream summer with the Wimbledon crown and first Grand Slam title as a pair
Russian seventh seed Daniil Medvedev, the 2023 Miami champion who arrived this year fresh off a run to the Indian Wells semi-finals, crashed out at the first hurdle as he fell 6-2, 6-3 to Spaniard Jaume Munar.
Talk about a man in a hurry -- 10th seed Ben Shelton required just 55 seconds to finish off Australian Rinky Hijikata and reach the Wimbledon third round on Friday.
Bhambri, Nedunchezhiyan-Prashanth reach ATP 250 doubles finals in China
'I think he's bringing a fresh look to my game and I'll be able to benefit from that, no doubt, on the court. But also that champion mentality he has, I'm sure we'll match very well.'
It may not quite be the end for British great Andy Murray at Wimbledon but it felt like it as the 37-year-old received an emotional farewell after he and brother Jamie were beaten in the first round of the men's doubles on Thursday.
Djokovic tamed local favourite Rinky Hijikata 6-3, 6-3 in what was the top seeded Serbian's first tour-level singles match since October.
Team Europe and Team World are tied at 2 after one day of the Laver Cup after play opened Friday in Berlin.
Andy Murray will not get another chance to feature on court in his farewell at the Grand Slam.
Carlos Alcaraz won two matches to lift Team Europe to a 13-11 victory over Team World for the Laver Cup title in Berlin.
Local favourite Thompson saved three match points before prevailing 5-7, 7-6 (6), 6-3 against Nadal, who was playing his first tournament after nearly a year out with a hip injury.
IMAGES from Day 2 of the US Open played at Flushing Meadows in New York on Tuesday.
Images from Day 3 of the US Open, at Flushing Meadows, New York.
IMAGES from Day 5 of the US Open, at the USTA Billie Jean King National Tennis Center, Flushing Meadows, New York, on Friday.