Harry Kane scored his 36th goal of the season but Bayern Munich let a second-half lead slip to draw 2-2 with Hamburg SV.
Napoli's injury concerns deepened in the second half when David Neres was seen limping off. The stoppage sparked a brief flashpoint between the two sides.
IMAGES from Serie A matches played on Sunday
Real Madrid's struggles continued on Sunday as they battled to a 1-1 draw at Girona in LaLiga.
A round-up of Tuesday's action in the UEFA Champions League.
A summary of Monday's action in LaLiga and Serie A.
Villarreal fought back to shock Barcelona 3-2 on Sunday, handing the LaLiga champions their first league defeat since late December.
All the action from La Liga and Serie A matches played on Sunday.
Napoli forward Lukaku, who has battled to regain match fitness after joining the club in late August, delivered an impressive performance with one goal and two assists.
Napoli thrash Palermo to advance to Coppa Italia last 16
Images from Sunday's action in LaLiga and Serie A.
Jude Bellingham converted a penalty and Kylian Mbappe added another goal before halftime to spur Real Madrid to a 2-0 victory over Getafe.
Ivan Toney, once Brentford's lynchpin in attack, has moved to Al-Ahli for 40 million pounds ($52.50 million).
Chelsea reached the Champions League quarter-finals as a first-half goal from Raheem Sterling and a controversial penalty by Kai Havertz overturned a first-leg deficit.
'We have a team with much potential and we are showing that in the Champions League. It's not for nothing we have made it to the quarter-finals'
Borussia Dortmund snatched a 1-0 victory over Chelsea in the Champions League round of 16 first leg on Wednesday
Holders Real Madrid were sensationally knocked out of the Champions League on Tuesday after being thrashed 4-1 at home by an outstanding Ajax Amsterdam who overturned a first-leg deficit to reach the quarter-finals 5-3 on aggregate.
Serbian midfielder Dusan Tadic said Zinedine Zidane had helped inspire what he described as the game of his life in Ajax Amsterdam's 4-1 drubbing of Champions League holders Real Madrid on Tuesday.
A round-up of Wednesday's action in the UEFA Champions League.
Ajax Amsterdam's Donny van de Beek grabbed an early goal to secure a precious 1-0 victory at Tottenham Hotspur in the first leg of their Champions League semi-final on Tuesday.
Images from the UEFA Champions League quarter-final first leg matches played on Wednesday
Roberto Firmino had a goal chalked off late in the first half after the referee awarded a foul against the hosts, before substitute Gabriel Jesus found the net on the hour mark only for a Video Assistant Referee (VAR) review to deem Firmino offside in the build-up. Brazil meet Peru in their final group game on Saturday with both sides needing only a draw to seal their place in the quarter-finals
Liverpool laboured to a 2-0 win over Denmark's Midtjylland on Tuesday as a goal from Diogo Jota and a Mohamed Salah penalty secured a hard-fought Champions League Group D victory at Anfield.
Teenager Curtis Jones grabbed a 58th-minute winner as an injury-hit Liverpool qualified for the knockout stage of the Champions League with a 1-0 win over Ajax Amsterdam at Anfield on Tuesday.
Christian Pulisic scored his 10th goal for the United States before being substituted after picking up a knock in a 1-1 draw with Chile in a friendly in Houston on Tuesday.
Images from the Champions League matches played across Europe on Tuesday
IMAGES from the Champions League matches played on Tuesday
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