Arsenal maintained control of the Premier League title race as they chiselled out a nervy 2-1 win over London rivals Chelsea to open up a five-point lead at the top of the table on Sunday.
Promoted Sunderland, who have defied expectations to stay in the top half of the Premier League table, could be the worst affected with six players going to the tournament, while the likes of Fulham, Manchester United, Burnley and Crystal Palace will also have to make do without some key personnel.
Manchester City's Erling Haaland became the fastest player to reach 100 Premier League goals to ignite their charge on Tuesday.
Bournemouth's Antoine Semenyo scored inside the first minute as they ended a run of eight games without a victory thanks to a 1-0 Premier League home win over Fulham on Monday, a result that reignites their hopes of European football next season.
Images from Thursday's action in the Premier League.
Liverpool moved one win away from sealing the Premier League title as substitute Trent Alexander-Arnold secured a 1-0 victory at Leicester City
IMAGES from the Premier League matches played on Sunday.
A round-up of Saturday's action in the Premier League.
IMAGES from the Premier League matches played on Tuesday.
A summary of Saturday's action in the English Premier League.
A summary of Saturday's action in the Premier League.
Marcus Rashford and Joshua Zirkzee bagged two goals apiece as Manchester United thumped Everton 4-0 on Sunday in new manager Ruben Amorim's first Premier League match at Old Trafford.
Images from the English Premier League matches played on Sunday night.
Cristiano Ronaldo came off the bench to earn Manchester United a hard-fought 2-1 victory at Everton in the Premier League on Sunday, taking his career goal tally to 700 in the process.
IMAGES from the Premier League matches played on Saturday.
IMAGES from the Premier League matches played on Saturday
Manchester City and Arsenal closed in on Premier League leaders Liverpool with contrasting victories on Saturday as Manchester United's bubble was burst by Fulham.
Aston Villa claimed their first three points of the Premier League Season
All the action from soccer matches played in Europe on Monday.
IMAGES from Premier League matches played on Saturday.
Images from the Premier League matches played on Saturday, March 9.
A summary of Sunday's action in the Premier League.
Norwich opened the floodgates in one of three earlier kickoffs, with their new U.S. international signing Josh Sargent and Greek winger Christos Tzolis each scoring twice on their full debuts at Carrow Road.
Images from the English Premier League matches played on Sunday.
Diogo Jota and Mohamed Salah were on target as Liverpool edged Premier League strugglers Nottingham Forest 3-2.
Images from the English Premier League matches played on Sunday.
IMAGES from the Europa League matches played on Thursday
Images from Saturday's action in the Premier League.
A summary of Tuesday's action in the Premier League.
Images from the English Premier League matches played on Sunday
Manchester City needed a second-half penalty from striker Erling Haaland to break the resistance of a dogged Crystal Palace.
A round-up of Saturday's action in the Premier League.
A Sergio Aguero hat-trick helped Manchester City get back to winning ways in the Premier League with a 3-1 victory over Newcastle United, as they stayed 12 points ahead of Manchester United who had to dig deep to secure a 1-0 win at Burnley.
IMAGES from the EPL matches played on Saturday
Ahmed Musa returned to the line-up with devastating effect as he scored both goals for Nigeria to help them resuscitate their World Cup hopes in a 2-0 win over Iceland at the Volgograd Arena on Friday.
Riyad Mahrez, who inspired Leicester City to an extraordinary Premier League title triumph last season, was named African Footballer of the Year on Thursday.
Manchester City suffered their first home Premier League loss in eight months as a shock 3-2 defeat by Crystal Palace on Saturday left Pep Guardiola's champions trailing leaders Liverpool by four points.
There was eye-catching sports action the world over and we summarise it all in this breathtaking photo feature...
A round-up of Saturday's action in the Premier League.
With United unable to sign a replacement, the pressure will be on 21-year-old England forward Marcus Rashford to deliver the goals in a more central role than he has previously operated in.