Promoted Sunderland, who have defied expectations to stay in the top half of the Premier League table, could be the worst affected with six players going to the tournament, while the likes of Fulham, Manchester United, Burnley and Crystal Palace will also have to make do without some key personnel.
Manchester United loosened Arsenal's grip on the Premier League title race with a 3-2 win in north London on Sunday.
IMAGES from Premier League matches played on Sunday.
Chelsea's Enzo Fernandez scored a smash-and-grab goal deep in injury time to salvage a 1-1 draw with Manchester City on Sunday.
Goals from Pedro Neto and Enzo Fernandez earned Chelsea a 2-0 victory at lowly Burnley on Saturday, a win that moved the Blues within three points of Premier League leaders Arsenal.
Arsenal beat Bournemouth 3-2 on Saturday to extend their lead at the top of the English Premier League.
IMAGES from the Premier League matches played on Sunday
Arsenal closed out 2025 in emphatic fashion, smashing third-placed Aston Villa 4-1 on Tuesday to surge five points clear at the top of the Premier League.
IMAGES from the EPL matches played on Saturday
Arne Slot planned to have a face-to-face meeting with Mohamed Salah on Friday ahead of Saturday's Premier League match against Brighton & Hove Albion.
The Egypt forward has been left out of the club's Champions League match against Inter Milan.
Arsenal marked Mikel Arteta's 300th game in charge with a convincing 2-0 home victory over West Ham United in the Premier League on Saturday.
A summary of Saturday's action in the Premier League.
Erling Haaland took his league tally this season to 11 in eight games with both goals in City's 2-0 home win over Everton -- a result that temporarily put City above Arsenal on goals scored.
Substitute Gabriel Martinelli scored a late goal to help Arsenal hold Manchester City to a 1-1 draw in a blockbuster English Premier League fixture, in London, on Sunday.
Crystal Palace scored a stoppage-time winner to edge Liverpool 2-1 while Manchester United and Chelsea lost by an identical 3-1 margin in the English Premier League on Saturday.
It took 10 Premier League games for the first cracks to appear in Manchester City's facade last season, but Pep Guardiola got a much earlier reminder of his side's fall from grace on Saturday in another defeat to Tottenham Hotspur.
Newcastle United made light work of north-east rivals Sunderland as Alexander Isak's double secured a 3-0 win and a place in the FA Cup fourth round at the Stadium of Light on Saturday.
A summary of Saturday's action in the Premier League.
A late penalty from new signing Lukas Nmecha earned promoted Leeds United a hard-fought 1-0 victory over Everton in their first match back in the Premier League.
Winning back-to-back titles for the first time since 1984 is likely to prove a rather more arduous challenge for Liverpool.
The commanding scoreline in the cross-town London derby came despite Chelsea's midfield talisman Cole Palmer being ruled out after he felt discomfort on the pitch during the pre-match warmup.
Fresh off a dominant title-winning campaign, Liverpool kick off the new Premier League season on Friday as the team to beat, as the Reds have transitioned from Juergen Klopp's high-octane chaos to a more measured possession-based style under Arne Slot.
Burnley beat Sheffield United 2-1 to seal automatic promotion to the English Premier League with the result also sending Championship leaders Leeds United up alongside them.
Norwich City winger Borja Sainz has been suspended for six matches and fined 12,000 pounds ($14,749) for spitting at an opponent.
To mark World Mental Health Day, English footballer Connolly opens up about alcoholism, rehab
Everton have signed David Moyes for a second spell as their manager, the Premier League club said on Saturday.
Dick Advocaat has quit as Sunderland's head coach after guiding them to Premier League safety, the north-east club said on Wednesday.
Sunderland named David Moyes as their new manager on Saturday, replacing Sam Allardyce who was appointed as England manager.
Dick Advocaat has stepped down as manager of Premier League Sunderland after less than seven months in the job, the club said in a statement on Sunday.
Sunderland became the first top-flight club in more than 100 years to fail to register a win in any of their first nine league games in two successive seasons when they suffered a 1-0 defeat by West Ham United on Saturday.
Roy Keane has agreed terms to take over as manager of second division Sunderland
Sunderland striker Jermain Defoe cashed in on a horrendous defensive mix-up to give his struggling side a much-needed 1-0 win at Crystal Palace in the Premier League on Monday.
Premier League teams Burnley and Middlesbrough were knocked out of the English Cup by lower-league teams in the second round on Wednesday.
Two goals from Kieran Richardson gave Sunderland a 2-0 victory over Portsmouth to boost their hopes of escaping the Premier League drop zone.
Sunderland are still not safe after losing 2-0 at Newcastle United in the day's second derby, Michael Owen scoring twice for Kevin Keegan's resurgent side at St James' Park.
Seb Larsson's late strike sent struggling Sunderland through to the League Cup quarter-finals with a 2-1 win over fellow Premier League side Southampton on Wednesday.
England international Adam Johnson has been sacked by Premier League Sunderland after he pleaded guilty to sexual activity with a child, the club said on Thursday.
English Premier League basement dwellers Sunderland have moved quickly to reinforce their frail defence by agreeing a loan move for Fiorentina fullback Marcos Alonso until the end of the season.
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