A round-up of Wednesday's night's UEFA Chmpions League matches.
Manchester City displayed champions' swagger as they roared clear at the top with a 5-0 trouncing of Burnley but it was drama which engulfed their neighbours Manchester United and Jose Mourinho that dominated the Premier League agenda on Saturday.
Liverpool had won each of their previous four home leagues games in which they conceded first and 12 minutes later they had turned another match on its head as Roberto Firmino's trickery set up Mane to give the hosts the lead at the second attempt.
Klopp fined by FA for referee comments after West Ham draw
Inter Milan's aversion to Europa League football continued with a 3-1 defeat at Sparta Prague, while AS Roma ended a continental hoodoo stretching back seven games with a 4-0 home win over Romanian side FC Astra on Thursday.
News of all that's transpired on and off the football field
Barca captain Messi opened the scoring with a "Panenka" penalty chipped straight down the middle in the 17th minute after Luis Suarez was fouled in the area, putting the home side ahead in the tie after a goalless first leg in France.
Ahead of their high-profile clash on Saturday, check out the five standout clashes between Arsenal and Chelsea.
Chelsea manager Jose Mourinho stoked up his war of words with Manuel Pellegrini on Monday by questioning the Manchester City manager's sums.
IMAGES from the English Premier League match played on Saturday
La Liga champions Real Madrid beat Getafe 3-1 on Saturday with a goal from Gareth Bale and two strikes from Cristiano Ronaldo to go 12 points behind leaders Barcelona and warm up for next week's Champions League game at Paris St Germain.
Cristiano Ronaldo scored twice as Real Madrid came from behind to beat Paris St Germain 3-1, while Sadio Mane grabbed a hat-trick as Liverpool demolished Porto 5-0 away in the Champions League round-of-16 on Wednesday.
Photos from the Premier League matches played on Sunday
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Manchester United manager Jose Mourinho has promised to show plenty of restraint and respect if he inflicts a first Premier League defeat of the season on his former side Chelsea on Saturday.
A Neymar double and a clinical finish from Luis Suarez handed Barcelona a comfortable 3-0 victory over BATE Borisov that put them on the verge of qualifying for the last 16 of the Champions League for the 12th consecutive season.
Sergio Aguero scored a hat-trick as free-scoring Manchester City climbed to the top of the Premier League with an irresistible 6-0 victory against Watford on Saturday.
While Lyon rallied to hold Leipzig 2-2 after a Memphis Depay strike, it was the English clubs who made a mark on the night. Liverpool and Chelsea moved into the last 16 with contrasting wins and now all four English clubs, including Manchester City and Tottenham Hotspur, are in the Champions League knockouts this season.
A summary of Thursday night's UEFA Champions League matches.
Mauricio Pochettino's Tottenham Hotspur can cement their status as the top dogs in the capital if they end an eight-year wait and defeat Arsenal in the North London derby on Sunday.
Barcelona's Lionel Messi rescued a 1-1 draw at Villarreal with a sensational late free-kick on Sunday but could not prevent the champions finishing the weekend third in La Liga, five points behind leaders Real Madrid.
He increasingly looks like a manager unable to cope with the modern tactical realities of football. His display of a fear of failure has been appalling to watch. But Mourinho getting the sack at this juncture will hardly solve the problem, says Dhruv Munjal.
Alex Oxlade-Chamberlain became the second England international to leave Arsenal in two days when he joined Premier League rivals Liverpool for a reported 40 million pounds on Thursday.
A summary of Saturday's matches in the English Premier League.
Injuries have blighted Liverpool's start but Adam Lallana is back in full training after damaging his thigh pre-season and is expected to feature while another injury concern, Sadio Mane, also trained on Wednesday after tweaking a hamstring on international duty with Senegal.
Ole Gunnar Solskjaer continued his dream start as Manchester United caretaker manager with a 3-1 Premier League win over Huddersfield on his Old Trafford debut in the dugout on Wednesday.
Tottenham Hotspur brutally exposed Liverpool's defensive frailties as Harry Kane plundered two more goals in his side's 4-1 romp at Wembley on Sunday.
Liverpool had to be satisfied with a 1-1 Premier League draw at Arsenal on Saturday as their usually prolific attacking trio were well shackled by their improving hosts.
A summary of Wednesday's matches in the UEFA Champions League.
Ethiopia ended the hopes of 2010 World Cup hosts South Africa from making next year's finals in Brazil after a dramatic round of African group stage qualifying matches on Sunday.
IMAGES from Saturday's English Premier League matches.
News of all that transpired on and off the football field.
Leicester's Mahrez finds form in time for January sales
Two big derbies and an eventful weekend of football awaits us all...
With Liverpool still to visit Chelsea, who trail them by nine points with two games in hand, Juergen Klopp's side may have to beat Brighton & Hove Albion on May 13 and rely on their superior goal difference to qualify for the Champions League, assuming they do not secure it by winning this year's trophy.
Real Madrid's Cristiano Ronaldo was the scourge of AS Roma again as he inspired the hosts to a 2-0 win and a place in the Champions League quarter-finals on Tuesday, scoring and setting up a goal Rodriguez to seal a 4-0 aggregate victory.
Jose Mourinho said he was sad to see midfielder Juan Mata leaving Stamford Bridge after confirming that the Spaniard's move to Manchester United was imminent on Friday.
News of all that's transpired on and off the football field
A summary of Tuesday's Group stage matches in the UEFA Champions League.
Manchester City claimed the win required to finally end Liverpool's relentless attempt to dethrone them as Premier League champions as they hit back from a goal down to crush Brighton and Hove Albion on the south coast on Sunday.