Second half goals from Presnel Kimpembe and Kylian Mbappe gave the impressive French side a clear advantage ahead of the return in Paris on March 6.
Javier Pastore and Edinson Cavani scored late as Paris St Germain ignored their fans' boos and recovered from a shaky start to beat visiting strugglers Evian Thonon Gaillard 4-2 on Sunday.
Lens falter in title race after draw at Nice, Marseille hit six
Football news from Ligue 1, Bundesliga and La liga.
Zlatan Ibrahimovic, facing multiple suspensions, struck twice to lift Paris St Germain to a crushing 4-0 victory over Bastia.
(Reuters) - Real Madrid, Manchester United and Paris St Germain reached the last 16 of the Champions League on Wednesday on a night when the goals flowed all over Europe with United the highest scorers in a 5-0 win at Bayer Leverkusen.
"This was one of the reasons why I took this opportunity. To train with all these personalities and this talent."
News of all that's transpired on and off the football field
A summary of Wednesday's group matches in the UEFA Champions League.
Edinson Cavani silenced his critics when he scored four goals in Paris St Germain's 6-0 victory at Caen in Ligue 1 on Friday.
All the latest football news from around Europe.
Zlatan Ibrahimovic was again the chief tormentor as French champions Paris St Germain won 3-0 at Bastia to stay eight points clear at top of the Ligue 1 on Saturday.
Spanish and French media reported on Tuesday that Real Madrid had made a 160-million-euro ($187.81-million) bid for the 22-year-old World Cup winner, who scored 42 goals in all competitions for PSG last season and has reportedly said he wants to move to Spain.
A new chapter in the celebrated rivalry between Cristiano Ronaldo and Lionel Messi will unfurl on Thursday when they meet in an exhibition match as the Portugal forward gears up for his first game in Saudi Arabia since joining Al Nassr.
News of all that's transpired on and off the football field
Barcelona are still trying to lure Paris St Germain centre back Thiago Silva to the Nou Camp but will look elsewhere if they fail to snare the Brazil international, coach Tito Vilanova said on Tuesday.
Wayne Rooney said he would pick Paris St Germain boss Mauricio Pochettino over Ajax Amsterdam manager Erik ten Hag to take over his former club Manchester United.
Arsenal will face manager Arsene Wenger's former club Monaco with defending champions Real Madrid pitted against German club Schalke.
Paris St Germain continued their irrepressible march towards a fourth consecutive Ligue 1 title with a 5-1 home win against Olympique Lyonnais to move 17 points clear at the top.
The Brazilian had to be substituted in the second half of his side's 2-1 Premier League win at Tottenham Hotspur on Saturday after clashing with the hand of opposition defender Jan Vertonghen.
With names of players, both, big and upcoming, and their possible moves, this is the day made by the gods of football.
News of all that's transpired on and off the football field on Friday
Lionel Messi was presented to fans during a glitzy event called 'The Unveil' at Miami's home stadium.
Bollywood star Ranveer Singh had a day to remember as he caught up with some of the world's greatest sportspeople at the Abu Dhabi F1 Grand Prix at the Yas Marina Circuit on Sunday.
Holders Barcelona will face fellow Spaniards Atletico Madrid, runners-up two seasons ago, in the Champions League quarter-finals following the draw in Nyon on Friday.
Holders FC Barcelona have been placed in Group E, along with Bayer Leverkusen, AS Roma, Dinamo Zagreb.
Spanish prosecutors are seeking a two-year prison term and a 10 million euro ($9.8 million) fine for Neymar.
The Portuguese can expect a hostile reception in Valencia, who had to suffer 15 of his goals for Real Madrid and are returning to the Champions League for the first time in three years.
'If there is a possibility, I would like to contribute again because it's the club that I love and I would love for it to continue doing well, to continue growing and to continue being one of the best in the world.'
He is scheduled to testify on Friday.
Di Maria to retire from international soccer after World Cup
Photos from matches played in the French Ligue 1 and Serie A matches played on Saturday
'But when I arrived in Barcelona, I was told that it was no longer possible, that I could not stay and that I had to find another club, because Barca could not afford to extend my contract. That changed my plans.'
Pochettino, who is well aware of Messi's game-changing abilities having worked with the 35-year-old last season, said he was still the best player in the world.
News of all that's transpired on and off the football field
Bayern Munich put upstarts RB Leipzig firmly in their place by sweeping to an emphatic 3-0 home win, with all the goals coming in the first half, in a disappointingly one-sided top-of-the-table Bundesliga clash on Wednesday.
'To see a player that I have always followed, who is an example for me, to see him leave now brings me a lot of pain.'
A summary of the results of the football matches played across Europe on Sunday
Manager Carlo Ancelotti said striker Kylian Mbappe's decision to snub Real Madrid and stay at Paris St Germain was not a distraction ahead of Saturday's Champions League final