Messi's lawyers informed Barcelona, on Tuesday, that the Argentine wanted to take up a release clause in his contract which could allow him to leave for nothing.
News of all that's transpired on and off the football field
A 3-0 reality check at the hands of Manchester City was always a moment waiting to happen for Southampton. Just how they bounce back from Sunday's defeat may now determine their fortunes this season.
The Argentine then lifted his shirt to reveal a red and black replica kit of his hometown club Newell's Old Boys bearing the number 10 which Maradona wore during his brief spell at the Rosario side in 1993.
Under the terms of the contract which expires in 2021, the only way Messi can leave without the club's consent is if a rival side pays his release clause of 700 million euros (629.7 million pounds).
Real and Barca have won the title in 15 of the last 16 seasons, with Atletico breaking the duopoly in 2014.
According to widespread Spanish media reports, Netherlands coach and former Barca defender Ronald Koeman is set to be named as Setien's successor.
Packed soccer schedule is a major problem as players will struggle to deliver their best
Barcelona continued their rampant run of domestic form to beat Osasuna 2-0 away from home on Saturday and move to within two points of La Liga leaders Atletico Madrid, with Lionel Messi setting up goals scored by Jordi Alba and teenager Ilaix Moriba.
A summary of Wednesday night's action in the UEFA Champions League.
Real Madrid coach Carlo Ancelotti said it was a "special feeling" and an extra motivation knowing he is poised to become the first man to coach six different clubs in the Champions League.
The 55-year-old Ernesto Valverde, who led Barcelona to successive La Liga titles in 2018 and 2019, came under fire this season for the team's dip in performance levels even though they top the league standings at the halfway point of the campaign.
Liverpool and Manchester United's globe-trotting squads must shake off the effects of international duty for one of English football's most eagerly-anticipated clashes on Saturday.
Lionel Messi scored twice as Barcelona crushed Getafe 5-2 on Thursday to stay in the hunt for the La Liga title.
Chelsea took a major step towards the Premier League title with an impressive 3-0 win over Everton at Goodison Park on Sunday.
News of all that transpired on and off the football field.
Alaba strike on Clasico debut gives Real Madrid 2-1 win at Barcelona.
Bayern Munich thrashed Bayer Leverkusen 5-1, while Barcelona came from behind to beat Valencia 3-1 in LaLiga at Camp Nou on Sunday.
Everton's Romelu Lukaku ended his longest goal drought in English football with an 11-minute hat-trick to power the visitors to an emphatic 3-0 win over Sunderland on Monday and third place in the Premier League table.
Atletico Madrid won the La Liga title for the first time since 2014
Lionel Messi has clearly become disenchanted with life at Barcelona.
Images from the soccer matches played across Europe on Saturday.
News of all that's transpired on and off the football field.
Champions Liverpool suffered a shock 1-0 defeat to lowly Burnley on Thursday, ending their 68 match unbeaten home record in the Premier League as their title defence continued to fade.
'Everton can confirm that Wayne Rooney has rejoined the club from Manchester United on a two-year deal for an undisclosed fee'
Italy returned to winning ways as Nicolo Barella's header just before halftime secured a 1-0 victory away to a below-par Netherlands in their Nations League clash at an empty Johan Cruyff Arena on Monday.
Images from the UEFA Champions League matches played on Tuesday night.
Wijnaldum followed up after France goalkeeper Hugo Lloris made a fine stop from point-blank range just before halftime and Depay sealed the victory to give the Dutch a chance to win the group when they meet Germany in Gelsenkirchen on Monday.
Former European champions Steaua Bucharest and English Premier League Southampton suffered shock defeats by Scandinavian teams in Europa League qualifiers on Thursday.
News of all that's transpired on and off the football field
Blunt manners, a willingness to adapt to local surroundings and the love of adventurous, attacking soccer make Dutch coaches favourites around the world.
Swedish striker Zlatan Ibrahimovic returned to Manchester United on a year-year contract "to finish what I started," the 35-year-old announced in a club statement on Thursday.
New AZ Alkmaar coach Dick Advocaat suffered a 1-0 defeat at former club PSV Eindhoven on his comeback to management in the Dutch league on Saturday.
Barcelona forwards Ousmane Dembele and Lionel Messi fired the Catalans to a confidence-boosting 2-0 win at in-form Sevilla on Saturday to keep the pressure on La Liga leaders Atletico Madrid.
Chelsea manager Jose Mourinho was fuming after his team were denied what he described as a 'Big Ben' penalty.
Roma teenager Afena-Gyan plays down apparent racist remark.
IMAGES from the Champions League matches played on Tuesday.
Yet even without a transfer fee, Messi's colossal salary, reported to be the highest in world football, means very few clubs would be able to afford him.
Lionel Messi scored his 650th goal for Barcelona while Antoine Griezmann struck the winner in a 2-1 home success over Athletic Bilbao
Images from football action around European leagues played on Sunday