Ole Gunnar Solskjaer's side, who had won their last ten away games in the Premier League, stay third on 27 points, a point behind second-placed Leicester.
IMAGES from the Champions League matches played on Wednesday.
Images from the UEFA Champions League matches on Tuesday night.
The loss was the joint-heaviest defeat by a side already crowned Premier League champions. Arsenal were beaten 4-0 at Liverpool in 1997-98 in the game after they clinched the title.
Images from football matches played in the Italian Serie A and the La Liga on Friday.
Unstoppable Bayern Munich forward Robert Lewandowski scored a hat-trick, taking his tally to 10 goals in five Bundesliga games, as the defending champions thumped hapless Eintracht Frankfurt 5-0 on Saturday.
Premier League leaders Manchester City recovered from two goals down to beat Championship side Swansea City 3-2 at the Liberty Stadium on Saturday and progress to the FA Cup semi-finals.
Images from the UEFA Champions League matches played on Wednesday night.
Leon Goretzka's 86th minute goal gave Bayern Munich a 2-1 victory over visitors Borussia Moenchengladbach on Saturday, meaning they need to win just one of their last three matches to secure the Bundesliga title.
News of all that's transpired on and off the football field
Liverpool started the ball rolling with a convincing 4-1 win at home to promoted Norwich and City responded a day later with an even more emphatic 5-0 victory at West Ham United.
The referee consulted with the VAR (video assistant referee) system before awarding the spot kick to Cueva after a foul by Yussuf Poulsen, but he spurned the chance to break the deadlock, firing the ball high over the bar.
IMAGES from Serie A matches played in Italy on Wednesday.
Kevin Gameiro grabbed a stoppage-time equaliser for Valencia after Denis Cheryshev had reduced the deficit with 20 minutes remaining, leaving the tie in the balance heading into the second leg at the Mestalla stadium on February 28.
Uruguay crushed Ecuador 4-0 in their Copa America opener on Sunday with help from an early sending off that deflated their opponents and assured the 15-times champions the simplest of starts to their campaign.
Mexico, needing only a draw to reach the World Cup round of 16, were level 0-0 with Sweden at half-time in their Group F match on Wednesday, after surviving an aerial bombardment and a VAR review.
Jubilant fans thronged central Belgrade, bringing traffic at the main Republic Square to a halt as they waved Serbian flags and hooted their car horns.
'But this was our first match point, if we compare this to tennis, our second match point comes against Portugal. We're still alive and dreaming'
New of all that's transpired on and off the football field on Saturday.
Images from football matches played in Europe on Sunday.
Liverpool prevailed to equal the record of 18 consecutive top-flight wins set by Manchester City in 2017.
Mourinho's side failed to turn their domination into more goals and things got edgy late on when Saville's shot evaded Gazzaniga who seemed slow to get down.
Images from football matches played in the La Liga, Serie A and Bundesliga on Saturday.
Images from Sunday's action in the Premier League.
News of all that's transpired on and off the football field
Lionel Messi dragged a nervous Barcelona to a 1-0 win at home to Levante in La Liga, while Cristiano Ronaldo converted two late penalties on his 100th appearance for Juventus in all competitions as the Serie A titleholders ground out a 3-1 win away to a dogged Genoa side.
Several brokers used shares of dormant or inactive clients to provide margins for other more active clients. This prompted Sebi to rework its entire system of pledging.
A last-minute own goal gave Liverpool a 2-1 win over Tottenham Hotspur to keep them top of the Premier League but Manchester City stayed two points behind having won at Fulham. Huddersfield Town were relegated after their defeat by Crystal Palace.
Serie A leaders Juventus scored twice in the last five minutes to win 3-2 at Inter Milan, who had earlier come from behind to lead despite playing with 10 men in an extraordinary match on Saturday.
Griezmann goal earns Atletico first win of season
Images from the FIFA World Cup qualifiers matches.
IMAGES from the UEFA Champions League quarter-final 2nd leg matches played on Tuesday
IMAGES from the English Premier League matches played on Sunday.
The draw interrupted a run of four straight league wins for Zinedine Zidane's side and left them second on 67 points after 31 games, three behind leaders Atletico who thrashed Eibar 5-0 earlier in the day.
Carlo Ancelotti's side held a two-goal lead at halftime thanks to strikes from Dries Mertens and Kostas Manolas, but Balotelli pulled one back as Brescia rallied after the break.
The World No 1 sustained the pace in the climbs up to the Col de Vars and the Col d'Izoard, both culminating at more than 2,000 metres, but then lost ground when his compatriot Thibaut Pinot accelerated to rein in defending champion Geraint Thomas.
Lionel Messi scored his maiden goal for Paris St Germain in Tuesday's 2-0 Champions League victory against Manchester City.
Sevilla in semis as Wolves miss penalty.
Bruno Fernandes and Edinson Cavani scored twice each as Manchester United took a giant step towards the Europa League final with a 6-2 drubbing of AS Roma in their semi-final first leg at Old Trafford on Thursday.
Ronaleo netted his 14th league goal for Juve this season while PSG's winning streak was snapped by Monaco in a 3-3 draw. Here are images from the matches played on Sunday
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