As tradition demands the Serb will open play on Centre Court on Monday as defending men's champion but rather than a gentle loosener the 28-year-old faces a real danger in the form of Germany's Philipp Kohlschreiber, the world number 33.
Serena Williams is a five-times Wimbledon champion but the American has surprisingly declared that she has "never really liked grass".
Angelique Kerber leapt into murky surroundings on Sunday, just hours after she became the first German since 1999 to win a grand slam tennis title by defeating world number one Serena Williams at the Australian Open. The 28-year-old's plunge into the Yarra River on Sunday, as a result of a bet with Eurosport journalist Matthias Stach, was an apt metaphor for what her life now holds. On Monday she is expected to rise to a career-high number two on the WTA Tour rankings. She can also expect a warm reception from her home country after she became the first German since her childhood idol Steffi Graf to clinch a grand slam, prompting congratulations from sportspeople and the country's President Angela Merkel. Kerber's victory also painted a large target on her back by proving that Williams was not invincible, though she was quick to acknowledge the American's powers were not on the wane.
Germany's experienced Angelique Kerber stands in the way of the 36-year-old American and an eighth, and arguably most impressive, All England Club singles crown which would see her match Margaret Court's all-time record of 24 Grand Slam titles.
Jana Novotna was a true winner but it was the misfortune of the brilliant Czech, who died on Monday aged 49, to always be recalled for one of sport's most famous and heart-rending meltdowns despite her collection of 100 tennis titles.
Serena Williams has buried the hatchet and will return to Indian Wells.
No 'Mean Girls' atmosphere in female tennis stars' locker rooms these days
Serena Williams kept her bid for a calendar-year Grand Slam on track, powering past big sister Venus 6-2, 1-6, 6-3 on a steamy star-studded night at the US Open in New York, on Tuesday.
'I'm not thinking ahead to the Open right now because I am here in Toronto and I haven't really played a hard court match in awhile. I'm thinking I want to get some of this under my belt and the Open will happen when the Open happens.'
If Serena Williams wanted to sound like someone who did not really care whether she won another Wimbledon or not, telling the world she just wanted to have fun, nobody was fooled on Thursday.
Twelve months on from making the most bizarre of exits from Wimbledon, drama queen Serena Williams will be back at the All England Club next week eager to complete the "Serena Slam".
Top seeds Novak Djokovic and Serena Williams face challenging early tests at the US Open following Friday's draws for the year's last Grand Slam starting on Monday.
The showdown will see world number one Serena Williams try to equal Steffi Graf's professional era record of 22 Grand Slam singles titles, while Angelique Kerber will seek to become the first German woman to lift the Wimbledon singles crown since her idol Graf 20 years ago.
A Champagne cork popped somewhere on Centre Court four games into Serena Williams's Wimbledon semi-final and while it was a tad premature, her 6-2 6-0 thrashing of Elena Vesnina suggested she could celebrating something special come Saturday. The top-seeded American will be taking nothing for granted, having seen her bid to match Steffi Graf's modern era record of grand slam titles stuck one short on 21 for a year, but it was a menacing show of strength, albeit against an overawed opponent.
The glittering career of Russian former World No 1 Maria Sharapova was in tatters after she was given a two-year ban by the International Tennis Federation. Check out the high points in her career...
Serena Williams enters the Australian Open as a strong favourite to lift the Daphne Akhurst Memorial Cup but is all too aware that a sixth Melbourne Park title has now eluded her for five years.
Following is a list of Serena Williams' 23 grand slam singles titles after the American surpassed Steffi Graf's professional era record with victory at the Australian Open on Saturday:
Serena Williams is on the brink of the grandest achievement in tennis, the single season Grand Slam, and even the leading men at the US Open championships starting on Monday are cheering her on.
For the second straight year Serena Williams saw her bid for a seventh U.S. Open title halted in the semi-finals with a 6-2 7-6(5) loss to Karolina Pliskova on Thursday that also ended her long reign as world number one.
American eighth seed Madison Keys claimed a dramatic 7-5, 4-6, 7-6(3) comeback win over a tearful Naomi Osaka on Friday to reach the fourth round of the US Open.
Serena Williams is third on the list of female Grand Slam title winners. She is one of only five women, after Maureen Connolly, Margaret Court, Martina Navratilova and Steffi Graf, to hold all four Grand Slam titles at same time.
If Williams is indeed 20 weeks into her term, that would mean she was approximately two months pregnant when she captured her record 23rd Grand Slam tournament singles title at the Australian Open in January.
"I prayed hard. Prayers not to win but for strength. All glory to God," the World No 1 said.
Serena Williams beat her sister Venus 6-4, 6-4 in the Australian Open final on Saturday to win her 23rd grand slam singles title and become the most successful tennis player in the open era.
Novak Djokovic and Rogerer Federer loom over Melbourne Park for the year's opening Grand Slam as favourites for the Australian Open as questions remain as to whether one of Generation Next could finally end their stranglehold.
Ailing knees, Father Time and even a resurgent Victoria Azarenka stand in the way of Serena Williams clinching her seventh Australian Open title and giving her one more shot at an achievement that would cap her storied career.
Serena Williams destroyed Romania's Simona Halep 6-3, 6-0 on Sunday to win the WTA Finals championship in Singapore, proving once again why she remains the most formidable force in women's tennis.
Mischa still finds time to tease 'Sascha', despite his little brother's rapid ascent up the tennis rankings.
Serena Williams crashed out of the US Open after losing in the semi-final to Karolina Pliskova costing her a shot at a 23rd Grand Slam title and resulted in her losing her record 187th straight week at number one.
List of Australian Open women's singles champions since the event began in 1922 (Australian unless stated):
It was third time lucky for American Serena Williams as she finally matched Steffi Graf's professional era record of 22 grand slam singles titles by beating Angelique Kerber to claim a seventh Wimbledon crown on Saturday.
It was Kristyna's first win over a top-five ranked player and she will go on to play fellow Czech Barbora Strycova in the quarter-finals.
Cricket aficionados' love, even passion, for their "god" Sachin Tendulkar is unlikely to recede even after his playing days.
World number four Petra Kvitova sealed the Fed Cup title for the Czech Republic with a thrilling win over Germany's Angelique Kerber, giving her country its third success in the premier team tournament in women's tennis in the last four years.
Sizzling hot Andy Murray roared into his seventh successive final with a commanding victory over Canadian Milos Raonic at the Western & Southern Open in Cincinnati on Saturday.
Serena Williams had been a vulnerable conqueror at this year's majors, living dangerously and dicing with defeat on numerous occasions as she tried to become only the fourth woman to complete the calendar Grand Slam.
Serena Williams battered Anastasia Pavlyuchenkova 6-4, 6-4 in the quarter-finals at Wimbledon on Tuesday, seizing on moments of weakness from the Russian to ram home her advantage.
Audacious coups by Andy Murray and Angelique Kerber have transformed the tennis landscape and they will begin 2017 eyeing the kind of domination that few would have thought possible at the start of a seismic year.
List of Australian Open women's singles champions since the event began in 1922 (Australian unless stated):
List of Wimbledon women's singles champions: