In other ties, Serie A champions Juventus face Europa League winners Atletico Madrid and Barcelona take on Olympique Lyonnais.
Their work in the transfer market has also added to the positivity around the club after German manager Juergen Klopp made some major moves that have clearly strengthened his squad.
Liverpool face Spurs in the game of the weekend, a day after title rivals Manchester City travel to struggling Fulham.
Bundesliga leaders Bayern Munich were made to work extremely hard for a 3-1 victory at VfB Stuttgart on Saturday that sent them eight points clear at the top of the table with five games left.
Manchester City's midfield powerhouse Yaya Toure will leave the club at the end of the season having not been offered a new contract, his agent said on Monday.
IMAGES from the English Premier League matches played on Saturday.
The league said last week that the deal, called 'Boost La Liga', would strengthen its clubs and give them funds to spend on new infrastructure and modernisation projects as well as increasing how much they could spend on players' salaries.
Manchester United should sack Louis Van Gaal and install his assistant Ryan Giggs as manager, according to former striker Dwight Yorke who wants to launch his own managerial career at struggling Aston Villa. The former Trinidad and Tobago striker said changes were needed at United, with the 20-times English champions sixth in the Premier League, out of the Champions League and suffering a 2-0 loss to arch-rivals Liverpool in the Europa League this week. "At the end of the day, it's all about results," Yorke was quoted as saying by Singaporean daily The New Paper on Saturday after a promotional event in the Southeast Asian citystate. "In the two years that he's (Van Gaal) been there, he's spent tons of money, brought in tons of players, and simply hasn't got the results that he and everyone else had hoped to. "You see a lot of young managers, Zinedine Zidane's been given the opportunity at Real Madrid, you got Luis Enrique at Barcelona, Pep Guardiola who's coming to Manchester City, Tottenham's Mauricio Pochettino, they're all ex-players. "And I feel that the game is going down that road, and maybe this is the right time to give Giggsy the job." Yorke won three Premier League titles and the 1999 Champions League with United under former manager Alex Ferguson after joining from Aston Villa.
News of all that's transpired on and off the football field
Images from the English Premier League matches played on Wednesday night.
Manager Arsene Wenger wants Arsenal to reinforce their title credentials by beating Manchester City in the Premier League on Sunday and called on his players to show no fear at the Etihad Stadium.
Manchester City's hopes of closing the gap on the Premier League pacesetters were frustrated as they were held to a 1-1 draw at home to lowly West Bromwich Albion on Tuesday.
Manchester City now need, at most, 11 points from their remaining seven matches to secure their third Premier League title in four seasons.
Arsenal's new manager Unai Emery faces a baptism of fire after the Gunners were handed an opening day fixture at home to Premier League champions Manchester City.
Guardiola said City had plenty of options, with Gabriel Jesus the only main striker fit and ready but Ilkay Gundogan and Raheem Sterling are able to slot into the role.
Sarri unmoved as Chelsea capitulation harms top-four hopes
Manchester City to beat second-tier Sheffield Wednesday 1-0 and reach the FA Cup quarter-finals but Jose Mourinho's problems piled up as his Tottenham Hotspur side were bundled out in a penalty shootout by Norwich City.
Liverpool boss Juergen Klopp has beaten Manchester United only twice in his career and never at Old Trafford -- his worst record against any Premier League side.
Manchester City marched into the quarter-finals of the Champions League
English clubs took their spending on players for the season soaring past 1 billion pounds on Monday, but the biggest signing on transfer deadline day was that of a manager as Manchester City confirmed Pep Guardiola will take over this summer.
Manchester City barely got out of second gear as they easily beat bottom club Huddersfield Town to close the gap on Premier League leaders Liverpool to four points on Sunday.
UEFA announced in a statement that City had committed "serious breaches" of the rules while the Premier League club swiftly said on their website that they will appeal the decision to the Lausanne-based Court of Arbitration for Sport (CAS).
Yet even without a transfer fee, Messi's colossal salary, reported to be the highest in world football, means very few clubs would be able to afford him.
Robert Lewandowski's hat-trick helped give coach Carlo Ancelotti a flying start to his first Bundesliga campaign as Bayern Munich cruised to an easy 6-0 win over Werder Bremen at the Allianz Arena on Friday.
Late goals by Mohamed Salah and Jordan Henderson earned Liverpool a crucial 3-1 victory at Southampton to move them back to the top of the Premier League on Friday.
Real Madrid will be without forward pair Cristiano Ronaldo and Gareth Bale, midfielder Toni Kroos and defender Pepe for Tuesday's UEFA Super Cup encounter with Sevilla in Trondheim, Norway.
The Danish international scored the winner as Spurs beat Bournemouth 1-0 in the Premier League on Saturday and Eriksen has set his sights on another good showing against the European champions at the Santiago Bernabeu.
Leicester City's attempts to sign Adrien Silva from Sporting Lisbon were dealt a blow on Wednesday, with FIFA saying it had rejected an FA petition to grant the midfielder an international transfer certificate.
On Sunday the Ukrainian Tennis Federation urged the sport's governing body the International Tennis Federation (ITF) to immediately expel Russia and Belarus from the organisation and ban Russia from team and individual tournaments. Also, athletes from Ukraine and other nations have called on the International Olympic Committee (IOC) to suspend Russia and Belarus and ban their athletes from events immediately.
Images from Saturday's action in the Premier League.
A preview of the line-up action in the English Premier League
News of all that's transpired on and off the football field.
Catalans will have to cope without their inspirational captain Andres Iniesta, the man who has pedigree when it comes to beating the Blues.
Pep Guardiola hailed Sergio Aguero's 'unique' skill of sniffing out chances in front of goal, and David Silva's ability to ghost past defenders
News of all that transpired on and off the football field
Pep Guardiola is a 'proven winner' who will take Manchester City to a 'whole new level', the Premier League club's chairman Khaldoon Al Mubarak has said.
Barcelona forward Luis Suarez scored a hat-trick as his side thrashed arch-rivals Real Madrid 5-1 on Sunday in a highly entertaining 'Clasico' which surely will signal the end of hapless coach Julen Lopetegui's spell in charge of Real.
Sheffield United's David McGoldrick scored twice as they stunned Chelsea with a 3-0 win at Bramall Lane on Saturday, loosening the visitors' grip on a Premier League top-four place. Raheem Sterling struck a hat-trick as Manchester City crushed Brighton 5-0 at the AmEx Stadium in the Premier League on Saturday.
Manchester City boss Pep Guardiola has warned his side to beware of Monaco's "killers in the box" when they host the principality club in the first leg of their Champions League, last 16 tie on Tuesday.
As Manchester City fans left Goodison Park after a 2-0 victory over Everton on Wednesday that sent their team back to the top of the Premier League, they aimed their chants across adjacent Stanley Park to title rivals Liverpool.
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