Promoted Sunderland, who have defied expectations to stay in the top half of the Premier League table, could be the worst affected with six players going to the tournament, while the likes of Fulham, Manchester United, Burnley and Crystal Palace will also have to make do without some key personnel.
Everton enjoyed their first Premier League win at Manchester United for 12 years despite playing virtually the entire game with 10 men.
Everton have signed David Moyes for a second spell as their manager, the Premier League club said on Saturday.
Manchester City's Erling Haaland became the fastest player to reach 100 Premier League goals to ignite their charge on Tuesday.
England midfielder Jack Grealish joined Everton on a season-long loan from Manchester City on Tuesday as he seeks to restart his stalled international career.
A late penalty from new signing Lukas Nmecha earned promoted Leeds United a hard-fought 1-0 victory over Everton in their first match back in the Premier League.
Manchester United's exiled forward Marcus Rashford has delivered a scathing assessment of the Premier League side's struggles
Images from the English Premier League matches on Saturday, August 30.
Fulham held visitors Manchester United to a 1-1 draw in the Premier League on Sunday.
Arsenal snapped a season-long jinx against Newcastle United with a nervy 1-0 win in their last Premier League home game on Sunday.
Liverpool continued their march towards the Premier League title with a 1-0 victory over Everton in a scrappy Merseyside derby as Diogo Jota slotted home the winner in the second half on Wednesday.
Graham Potter is in talks to replace Lopetegui, according to British media reports, and the former Chelsea and Brighton & Hove Albion manager is expected to take charge of West Ham for their FA Cup third-round game at Aston Villa on Friday.
Champions Manchester City could only muster a 2-2 Premier League draw with Brighton & Hove Albion on Saturday.
A round-up of Saturday's action in the Premier League.
Leandro Trossard transformed the mood at Arsenal with the winning goal as they recovered from an early setback to beat Tottenham Hotspur 2-1 at home.
Images from Saturday's action in the Premier League.
IMAGES from the Premier League matches played on Saturday.
A round-up of Saturday's action in the Premier League.
A round-up of Wednesday's action in the Premier League
'I hope we will all look back and think: 'Maybe we were indulging too much'
The government last month opened the door for elite sport to resume and the Premier League said it would restart its season on June 17.
A round-up of Saturday's action in the English Premier League.
'That's what I do, I win. And I'm coming here to West Ham initially to try and get us wins and away from the wrong end of the table'
Alex Ferguson may have been stripped of his Manchester United ambassadorial role last week but his legacy as manager remains a stifling cloud for those following in his footsteps, with Erik ten Hag the latest to be jettisoned after failing to measure up.
IMAGES from the Premier League matches played on Sunday
Sunderland named David Moyes as their new manager on Saturday, replacing Sam Allardyce who was appointed as England manager.
Ruben Amorim is set to become the next manager of Manchester United with the Premier League club prepared to pay Sporting the 10 million euros ($10.79 million) release clause, the Portuguese club said on Tuesday.
Manchester United manager David Moyes has been charged with misconduct for his post-match comments about the referee after Tuesday's League Cup defeat at Sunderland, the Football Association said on Friday.
Manchester United appointed David Moyes to succeed Alex Ferguson as manager on Thursday and the Everton boss has signed a six-year contract with the Premier League champions.
Former Everton, Manchester United and Sunderland manager Moyes, who replaced the sacked Slaven Bilic, has a track record of turning to a good old-fashioned No. 9 to grind out results.
New Manchester United manager David Moyes was adamant on Friday that striker Wayne Rooney was not for sale but stopped short of saying the player had changed his mind about wanting to leave.
Villa remain fourth on 56 points, three points above Spurs in fifth, having played a game more. West Ham are seventh on 44, three points behind sixth-placed Manchester United who have a game in hand.
The Everton manager is to sue his former protege Wayne Rooney over comments made in the 20-year-old's autobiography.
Jose Mourinho has been charged with misconduct in the wake of his comments about referee Anthony Taylor before Manchester United's goalless draw with Liverpool last week, the Football Association said on Thursday.
Manchester United manager David Moyes said he would consider loaning out Wilfried Zaha, although he has not had any offers for the 21-year-old.
Everton manager David Moyes admitted an FA charge of improper conduct on Monday after his reaction to a decision by the referee in a Premier League match against Stoke City two weeks ago.
Former Everton and Manchester United manager David Moyes has agreed to take over as head coach of Real Sociedad until 30 June 2016, the La Liga club announced on their website
Everton chairman Bill Kenwright cut a resigned figure after meeting manager David Moyes late on Wednesday, admitting he could do little to prevent the Scot from making the seemingly inevitable move to Manchester United.
Everton manager David Moyes is to sue a newspaper over comments it published from Wayne Rooney's autobiography.
Bookmakers were quick to install Everton manager David Moyes as the favourite to replace Alex Ferguson, who announced he was stepping down as boss of Manchester United on Wednesday after more than 26 trophy-laden years in charge.
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