Manchester United, winners of the competition in 2017, will have a lot of travelling to do to Eastern Europe after being drawn alongside Kazakhstan side Astana, Serbia's Partizan Belgrade and Dutch side AZ Alkmaar.
In the third-tier Europa Conference League, English Premier League club Leicester City will face Danish side Randers and Scottish club Celtic will take on Norwegian champions Bodo/Glimt in the knockout playoff round.
Tottenham Hotspur secured a place in the Europa League next season as they closed out their Premier League campaign with a 1-1 draw at Crystal Palace on Sunday.
Manchester City and Chelsea both secured their Champions League places with victories on the final day of the English Premier League season and Newcastle United joined them despite stumbling to a last-day defeat.
Images from Europa League matches played on Thursday.
However, there was a softening in tone over eventual cases where league seasons may be cancelled -- an outcome UEFA had been quick to oppose.
IMAGES from Europa League matches played on Thursday.
Sevilla in semis as Wolves miss penalty.
Europe's top club coaches gave their support on Thursday to the much-maligned Europa League.
Barcelona will face a struggling Galatasaray team who are 13th in the Turkish top-flight.
Son Heung-min said returning to his home country South Korea for the World Cup qualifiers against Oman and Jordan has brought him immense joy
AS Roma secured their place in the Europa League last 16 with a 3-2 home win over 10-man Porto on Thursday thanks to a Paulo Dybala double, advancing 4-3 on aggregate.
Arsenal can sustain a Europa League challenge but a top-four finish in the Premier League would be the best way to reach next season's Champions League, manager Arsene Wenger has said.
Pogba, who rejoined United from Juventus last year, started all 15 games and scored three times in Europe's second-tier competition to help United lift the trophy for the first time in May.
Arsenal defeated London rivals Chelsea 1-0 for their first win in four Premier League games on Sunday as a headed goal by stand-in striker Mikel Merino boosted their faint hopes of catching up with runaway leaders Liverpool.
Moroccan Yassine Bono denied Marcus Rashford, Bruno Fernandes, Mason Greenwood and Anthony Martial in either half of the match to keep the match alive
Tottenham defender Dragusin out with ACL injury
IMAGES from Europa League matches played on Thursday.
UEFA bowed to the inevitable on Wednesday and suspended all Champions League and Europa League matches 'until further notice' due to the coronavirus pandemic.
Real Madrid fight back to beat Mallorca and put Barca party on hold
Images from UEFA Europa League semi-finals played on Thursday.
The 24 sides through from the group phase join the eight third-placed finishers in the Champions League in Monday's draw, including Manchester United and Ajax Amsterdam.
Chelsea beat London rivals Tottenham Hotspur 1-0 on Thursday thanks to a goal by Argentina's Enzo Fernandez
IMAGES from Europa League matches played on Thursday.
Newcastle United registered a 2-0 home win over Chelsea on Sunday that moves the Magpies a step closer to Champions League football next season.
A round-up of Saturday's action the Bundesliga, Ligue 1
Liverpool roared back from a goal behind to thrash Tottenham Hotspur 5-1 and wrap up the English Premier League title in style.
AC Milan have been drawn to play Manchester United in what is the standout tie in next month's Europa League round of 16.
Manchester United manager Jose Mourinho said Friday's draw for the last 16 of the Europa League against Russian side Rostov has been unkind to his team, the favourites.
La Liga club Villarreal have been given Real Mallorca's place in this season's Europa League pending a Mallorca appeal.
We want to fight for that title and we are very excited to see the draw, says Ander Herrera
IMAGES from Premier League matches played on Sunday.
IMAGES from the Europa League matches played on Thursday
Defender Kolo Toure believes Liverpool can recover from Sunday's painful League Cup final shootout defeat against Manchester City at Wembley and rescue their season by winning the Europa League. Juergen Klopp's side, seeking their first trophy in four years, face bitter rivals Manchester United this month in the last-16 of the continent's second tier competition. "You have to learn to lose sometimes before you win. We learn as a team together. The Europa League can save the season and the Premier League is not over yet," Toure told British media. Liverpool, who are ninth in the table, can quickly avenge Sunday's defeat when they host fourth-placed City in the Premier League on Wednesday. Goalkeeper Simon Mignolet said it was important for the five-times European champions to bounce back quickly from their Wembley disappointment.
UEFA has postponed all Champions League and Europa League matches due to take place next week because of the coronavirus outbreak, European soccer's governing body said in a statement on Friday.
Eintracht Frankfurt won the Europa League final after holding their nerve to beat Rangers 5-4 in a clinical penalty shootout as they claimed their first European trophy in 42 years.
IMAGES from the Europa League matches played on Thursday
European champions Chelsea will play Czech side Sparta Prague in the last 32 of the Europa League after the draw was made in Switzerland on Thursday.
Alexandre Lacazette's free-kick sent Arsenal into the Europa League semi-finals with a comfortable 1-0 win away over Napoli, while Chelsea beat Slavia Prague 4-3 in a roller-coaster game, helped by a Pedro brace.
Tottenham Hotspur have been fined 15,000 euros ($18,600) by UEFA after their Europa League game against Partizan Belgrade last month was suspended for several minutes following three separate pitch invasions, the governing body said on Thursday.