Rewind five years and Liverpool hosted Chelsea with three games remaining, knowing victory would have left them six points clear and a first league title since 1990 almost secure.
After bagging the League Cup, being locked in a titanic battle with Liverpool for the Premier League title and in the Champions League quarter-finals, Pep Guardiola's side remain on course for an unprecedented clean sweep.
With no Champions League football for a third straight season, the financial realities are starting to bite and Arsenal will be desperate for some of their talented youngsters to come through.
Images from the UEFA Champions League matches played on Wednesday night.
A preview of the line-up action in the English Premier League
Chelsea beat Arsenal 3-2 in a pulsating London English Premier League derby on Saturday with defender Marcos Alonso scoring an 81st-minute winner after the Gunners had fought back from an early 2-0 deficit.
Liverpool beat Leicester City 2-1 to post a fourth successive Premier League victory but conceded their first goal of the season after a nightmare mistake by new keeper Alisson.
IMAGES from the English Premier League matches played on Tuesday
English Premier League matches have continued behind closed doors during the second lockdown announced on November 1. Supporters have not been allowed into sporting venues since the first lockdown was announced in March, barring a few exceptions.
Manchester United have scored 14 goals and earned maximum points from their four matches under interim boss Ole Gunnar Solskjaer.
Tottenham Hotspur missed the chance to move up to provisional fourth place in the Premier League after relegation-threatened Newcastle United held them to a 2-2 draw with a late equaliser from substitute Joe Willock at St James' Park on Sunday. Images from EPL matches played on Sunday.
Paris St Germain will play Borussia Dortmund and Barcelona were pitted against an unpredictable Napoli, while Chelsea were drawn against Bayern Munich. City, who will be at home in the second leg, have yet to beat the Spanish side with two draws and two defeats in their previous four meetings.
News of all that's transpired on and off the football field
Liverpool's Sadio Mane marked his return from injury with a late goal to break Norwich City's resistance and secure a 1-0 win on Saturday to extend his side's Premier League lead to 25 points.
News of all that's transpired on and off the football field
Real Madrid coach Zinedine Zidane said he was disappointed that he was only asked about the referee's decisions after his side earned a 2-1 victory at Real Sociedad on Sunday to climb above Barcelona and top La Liga.
Liverpool will attempt to sweep away the January blues on the last day of a wretched month when they host commanding Premier League leaders Chelsea at Anfield on Tuesday.
The only speculation around Old Trafford these days as one of the world's great clubs continue their laborious struggle to rediscover the halcyon days of the Alex Ferguson era seems to be not if, but when this dream alliance will end in divorce.
Images from the League Cup matches played on Tuesday
But for third-placed Spurs, who trail leaders Manchester City and Liverpool by five points, this may prove to be a loss that leaves them with too much ground to make up.
IMAGES from the EPL matches played on Saturday
High drama ensued during the English Premier League matches on Wednesday as Spurs manager Jose Mourinho was booked while Brighton stunned Chelsea via Alireza Jahanbakhsh's superb equaliser to deny the Blues victory. Here is all the EPL action in IMAGES from Wednesday's matches.
News of all that's transpired on and off the football field
Brighton & Hove Albion scored three times in the second half to fight back from two goals down and beat Manchester City
Chelsea's new signing Gonzalo Higuain netted his first two Premier League goals in Chelsea's 5-0 thrashing of Huddersfield Town while Tottenham Hotspur's Son Heung-min struck late for a 1-0 win over Newcastle United as they moved into second place.
Chelsea manager Antonio Conte was fuming at the final whistle after Pedro and Alvaro Morata were dismissed in extra time and two penalty appeals had been waved away, but the Premier League champions regained their composure to win the shootout 5-3.
'Soul might not win trophies. But, unlike trophies, soul actually matters,' says Shougat Dasgupta.
Manchester City's stellar season gathered yet more momentum as the runaway English Premier League leaders reached the League Cup semi-finals with a penalty shootout victory at Leicester City.
Manchester City stumbled to the most unexpected defeat of the Premier League season on Saturday before neighbours Manchester United began their brave new world under Ole Gunnar Solskjaer with a glorious reminder of long-forgotten attacking swagger.
Ten-man Arsenal suffered a 3-0 Premier League defeat at Leicester City on Sunday in another blow to their hopes of finishing in the top four and qualifying for the Champions League.
Messi, whose deal expires in 2021, had called his side "weak" and "inconsistent" after they lost the league title to Real Madrid.
Minor league Eastleigh suffered FA Cup heartbreak when they conceded a late equaliser to four-times winners Bolton Wanderers on a gluepot pitch at their snug Ten Acres ground on Saturday.
City's Aguero doubtful starter for Watford trip
IMAGES from the English Premier League matches played on Wednesday.
News of all that's transpired on and off the football field
Mourinho's tinkerings meant a first start of the season for midfielder Scott McTominay, playing on the right of a three-man defence, while Anthony Martial played instead of the dropped Alexis Sanchez. On this evidence, more changes may be needed when United take on Valencia in the Champions League on Tuesday.
Spaniard Herrera finished off a fine move with a precise header from Pogba's cross just past the half-hour and United's French midfielder scored himself when he nodded powerfully home from a Marcus Rashford delivery before the break.
News of all that's transpired on and off the football field
De Bruyne out for up to six weeks due to injury, says Guardiola.
Included in Barcelona squad to face Dortmund