It was heartbreak for the Americans, who finished runners-up in 2008.
The three Premier League and three La Liga clubs in the last eight avoided each other, with Manchester City up against Atletico Madrid and Liverpool to face Portuguese side Benfica.
Barcelona were drawn in Group E with Bayern Munich, Benfica and Dynamo Kyiv.
Images from UEFA Europa League semi-finals played on Thursday.
Real Madrid's Karim Benzema, who won the 2022 Ballon d'Or award, is also in the shortlist.
UEFA opens investigation into Barca payments to ex-refereeing official
India open FIFA women's U-17 WC campaign against USA with hope to get at least a point
Tottenham Hotspur's Son Heung-min returned to form with two goals in his side's 3-0 defeat of second-tier Preston North End in the FA Cup fourth round and Casemiro also grabbed a brace in Manchester United's 3-1 win over Reading.
Atletico Madrid won the La Liga title for the first time since 2014
IMAGES from the football matches played across Europe on Sunday.
Bruno Fernandes and Edinson Cavani scored twice each as Manchester United took a giant step towards the Europa League final with a 6-2 drubbing of AS Roma in their semi-final first leg at Old Trafford on Thursday.
Victory in their first match on the league's resumption after the COVID-19 stoppage took basement team Espanyol to 23 points from 28 games, three points off the safety zone.
IMAGES from Europa League matches played on Thursday.
Manchester United were mistakenly drawn with Villarreal, even though both teams faced each other in the group stage while the Premier League side's ball was not added to the bowl as a potential opponent for Atletico Madrid.
Images from the UEFA Champions League matches on Tuesday night.
The FIFA 2022 World Cup will kick-off in Qatar on Sunday, November 20. Here is a list of the 26-man squads playing in the quadrennial global football extravaganza.
Players who have been ruled out or are doubtful for the 2022 World Cup.
Manchester United sacked manager Ole Gunnar Solskjaer on Sunday, a day after a 4-1 defeat by promoted Watford left the Old Trafford club seventh in the Premier League.
Barcelona clinched a 1-0 away win at Atletico Madrid, while AS Roma held AC Milan to a 2-2 draw.
Runaway Premier League leaders Manchester City will play Borussia Dortmund with the winners to face either Bayern or PSG in the semi-finals.
Cristiano Ronaldo has been voted Manchester United's Player of the Month for September by the club's supporters.
Champions Real Madrid earned a 2-0 win in a feisty LaLiga encounter at Athletic Bilbao on Sunday to ensure they stayed in the hunt for the LaLiga title with leaders Barcelona.
Midfielder Santi Cazorla gave the home side the lead in the fourth minute of the game, which was rescheduled due to Real's participation in last month's Club World Cup, by bending a wonderful shot into the bottom corner.
Given a contract until 2024, the 41-year-old made a winning start on Saturday with a victory over Espanyol that put Barcelona sixth in LaLiga on 20 points after 13 matches.
Roma teenager Afena-Gyan plays down apparent racist remark.
A summary of all things football.
Real Madrid clinched a record-extending 34th La Liga title with one game to spare by beating Villarreal 2-1 at home on Thursday thanks to two goals from their leading scorer Karim Benzema. Real have 86 points after 37 games, seven more than deposed champions Barcelona who were beaten 2-1 at home to Osasuna.
Sky reported Manchester United, Manchester City and Chelsea have been in touch with Kane's representatives.
Manchester United forward Marcus Rashford returned to full training after a recent shoulder operation and should be available after the international break, manager Ole Gunnar Solskjaer said.
Images from Tuesday's action in the UEFA Champions League.
Ferran Torres scored a brace and Ousmane Dembele made two assists as a red-hot Barcelona rolled over Osasuna 4-0 on Sunday to earn their fourth consecutive LaLiga win.
Porto's Radamel Falcao scored a hat-trick to help the newly-crowned Portuguese champions thrash Spartak Moscow 5-1 as goals flowed and South American players shone in Europa League quarter-final first leg ties on Thursday.
'It wasn't easy, but I called him last night (Sunday) and we had a difficult and tough conversation. I feel bad as he's a player who has always been at the top level and has a future with the national team.'
Atletico Madrid's problems deepened as they were held to a 0-0 draw at Villarreal in La Liga on Friday, stretching their winless run to four games in all competitions.
There were a few nerves at the end but Liverpool set up a Champions League semi-final with Spain's Villarreal after Roberto Firmino scored twice in a 3-3 second-leg draw with Benfica on Wednesday to ensure a 6-4 aggregate win.
Third-placed Inter Milan scored twice in the last six minutes through Stefan De Vrij and Alessandro Bastoni to snatch a 2-1 win at Parma in Serie A on Sunday despite a subdued display. The scarcely-deserved victory left Inter eight points behind leaders Juventus and four adrift of second-placed Lazio with 10 games each to play.
AC Milan grabbed a 1-1 draw at Manchester United in the blockbuster Europa League last-16 first-leg at Old Trafford on Thursday.
The 33-year-old Messi, who signed his last contract in 2017, has become more outspoken against the club's hierarchy in the last year and radio station Cadena Ser said last Thursday he is unhappy with how Barca is being run and wants to leave in 2021.
Paris Saint Germain's Neymar, Laywin Kurzawa and Leandro Paredes as well as Marseille's duo of Dario Benedetto and Jordan Amavi were given their marching orders after rival players threw punches and kicks at each other.
Villarreal youngster Ashique Kuruniyan, signed on loan from Indian Super League club FC Pune City, is set for a spell on the sidelines after picking up an injury.
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