Madrid went into halftime with a three-goal lead after Marco Asensio scored twice in three minutes and debutant Javi Sanchez also got on the scoresheet late in the half.
France and the Netherlands are level on four points at the top of the group standings, with Austria on three, while Poland have no points and cannot advance to the last 16.
Roy Makaay scored a first-half hat-trick to steer Feyenoord to a 3-1 win over FC Groningen and a place in the last 16 of the Dutch Cup on Thursday.
The Premier League's bottom two clubs met at Goodison Park and there was more woe for Everton as they bowed out on penalties to Southampton after a 1-1 draw.
Liverpool draw Sparta Prague in Europa League last 16
Slovakia, Hungary and Northern Ireland were all assured of qualifying for the last 16 at Euro 2016 on Tuesday despite not playing, or in Northern Ireland's case, losing.
Mudryk is known for his quirky, and very small, custom-made shin pads. He has one pair inscribed with a Christian-inspired message "Can't, Can't, Can't, Can"
Turkey defender Merih Demiral is to be banned for two games by UEFA following a gesture he made during his side's last-16 win against Austria on Tuesday and will miss Saturday's Euro 2024 quarter-final against Netherlands, German media reported.
Italy's media lambasted the country's soccer squad over their elimination from Euro 2024 at the hands of Switzerland on Saturday
Images from the Champions League matches played on Tuesday
Kai Havertz and Jamal Musiala's second-half goals sent Germany into the Euro 2024 quarter-finals with a 2-0 win over Denmark on Saturday after their last-16 clash was delayed by thunderstorm.
Manchester United and Liverpool, English football's two most decorated clubs, were drawn together in the last 16 of the Europa League on Friday.
Round up of the Champions League matches played on Wednesday.
The English champions will go through to the last 16 of the Champions League if they overcome Real Betis in Seville.
Christian Eriksen kept Tottenham Hotspur's hopes of completing a remarkable salvage job and reaching the last 16 of the Champions League alive with a late winner in his side's 1-0 victory over Inter Milan at Wembley on Wednesday.
In the latest of a slew of sanctions against participating countries for fan misbehaviour, UEFA also fined the English Football Association 10,000 euros for crowd disturbances and 1,000 euros for lighting of fireworks during the Slovakia game.
Arsenal will face manager Arsene Wenger's former club Monaco with defending champions Real Madrid pitted against German club Schalke.
'Samsung declared they would not allow the presence of any trade union.' 'This is unacceptable as the rule of law in India permits employees to have a trade union.' 'So, the crux of the strike is this.'
Rafael Nadal held off a fierce challenge from one of the hottest prospects in the game when he outlasted German teenager Alexander Zverev 4-6, 6-3, 6-7(5), 6-3, 6-2 to reach the last 16 of the Australian Open.
Two goals by Paraguay striker Oscar Cardozo helped Benfica to a 4-0 win over Hertha Berlin on Tuesday to clinch a place in the last 16 of the Europa League.
Images from the UEFA Champions League matches played on Wednesday.
Images from the Euro 2024 Group D match between France and Austria at Dusseldorf Arena, Dusseldorf, Germany, on Monday.
Here is a quick glance of all the highs and lows from Nadal's stupendous career:
Germany coach Joachim Loew is confident key centre back Jerome Boateng will be fit for his side's last-16 encounter despite coming off with a calf problem during Tuesday's 1-0 victory over Northern Ireland.
Switzerland edged closer to a place in the knockout stages of Euro 2016 when they fought back to draw 1-1 with Romania in a lively Group A game at the Parc des Princes on Wednesday.
Angelique Kerber, Naomi Osaka and Caroline Wozniacki have been handed wild cards into the main draw of next month's Wimbledon
With the loser likely to face hosts Brazil in the next round, the Netherlands and Chile will go all out for victory when they meet in their Group B match on Monday, even though both teams are through to the last 16.
Like a medieval army picking an elevated spot to engage in battle, Albania were happy to concede territory up the field in favour of packing the final third, safe in the knowledge that Croatia would not hurt them.
Group C leaders Barcelona should make it four wins from four matches against pointless Basel on Tuesday in the Champions League, while holders Manchester United can book their last 16 place with victory at Celtic.
Defending champion Novak Djokovic defeated Belgium's Steve Darcis 6-0, 7-5 on Monday to power into the last 16 of the Miami Open.
The Chirag-Satwik pair won the Thailand Open in May to reclaim the No.1 ranking but suffered loss of form and made a first-round exit from the Singapore Open last month.
Fresh off winning the Stuttgart Open by beating former world number six Matteo Berrettini, Draper put on a near flawless display
Benfica snatched a 2-2 draw at sloppy Manchester United to reach the Champions League last 16 and leave the three-times winners with work to do, while Inter Milan ambled through before even playing and Bayern Munich also progressed with ease on Tuesday.
Bhajan Kaur clinched India an Olympic individual quota in style, winning a gold medal
Can see growth, especially in women's table tennis in India: Manika Batra on UTT
A closer look reveals a team riddled with selection issues courtesy of a string of injuries to key players
Barcelona and AC Milan qualified for the last 16 of the Champions League as expected with room to spare on Tuesday and surprise package APOEL Nicosia are poised to join them after continuing to punch above their weight.
Images from the Euro 2024 quarter-final between Portugal and France, at Hamburg Volksparkstadion, Germany, on Friday.
Andy Murray reprised his familiar role of being the last British singles player heading into Wimbledon's second week.