Inter Milan's aversion to Europa League football continued with a 3-1 defeat at Sparta Prague, while AS Roma ended a continental hoodoo stretching back seven games with a 4-0 home win over Romanian side FC Astra on Thursday.
Real Madrid earned their first-ever win over Liverpool with a wondrous Cristiano Ronaldo goal spearheading a 3-0 Champions League victory at Anfield on Wednesday which appeared as classy as it was dominant.
Bundesliga leaders Bayern Munich survived several first-half scares in a 1-1 home draw with midtable Schalke 04 on Saturday as Philipp Lahm made his 500th appearance for the Bavarian club.
Photos from matches played in the French Ligue 1 and Serie A matches played on Saturday
A beautifully-worked Antonio Di Natale goal saw lowly Udinese beat AC Milan 1-0 in Serie A on Saturday to deal a huge blow to the visitors' prospects of European football next season.
Liverpool manager Brendan Rodgers believes his team are back to their sizzling form of last season after a superb victory over Tottenham defied those who predicted a gloomy outlook in the post-Luis Suarez era.
Cristiano Ronaldo hit back at critical former boss Jose Mourinho in the best way possible on Wednesday with two goals to help Real Madrid beat Chelsea 3-1 and win the International Champions Cup pre-season tournament.
Nineteen-year-old forward Domenico Berardi scored four quickfire goals to give Sassuolo a 4-3 win over AC Milan on Sunday after they overturned an early two-goal deficit against the seven-times European champions.
Despite all the hype, however, the match will do well to live up to some of the Manchester derby tussles down the years. Here are five of the most memorable:
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A much-changed Real Madrid ground out a 2-0 victory at third-tier Fuenlabrada in their King's Cup last-32 first leg on Thursday, needing two dubious penalties to break down their stubborn hosts as both sides finished with 10 men.
Three time European champions Inter Milan were stunned 2-0 at home by Israeli side Hapoel Beer-Sheva and Manchester United were floored by a late goal from Feyenoord as the Europa League group stage got underway on Thursday.
Alan Pardew's dream of reprising a celebrated 25-year-old FA Cup triumph was scuppered by Liverpool as the seven-times champions came from behind to book a place in the quarter-finals with a 2-1 win at Crystal Palace on Saturday. This year's shock-laden competition had continued with second-tier Blackburn Rovers' 4-1 thrashing of the Premier League's Stoke City.
Real Madrid keeper Iker Casillas believes the European champions have a side with the potential to be one of the all-time greats and it will be with likely trepidation that an off-colour Liverpool visit the Bernabeu on Tuesday.
Liverpool scored a stunning 3-2 win over Queens Park Rangers with four of the five goals coming in the last seven minutes capping an astonishing finale to their Premier League match at Loftus Road on Sunday.
American swimmer Michael Phelps, the most decorated Olympian of all time, was suspended for six months by USA Swimming on Monday following his recent arrest on a drunken driving charge.
Holders Real Madrid breezed into the last 16 of the Champions League with two games to spare when a Karim Benzema strike secured a 1-0 win in their Group B match at home to a toothless Liverpool on Tuesday.
Playmaker Kaka breathed new life into struggling AC Milan by scoring twice and 18-year-old Bryan Cristante claimed his first professional goal as they beat Atalanta 3-0 on Monday for only their fifth league win of the season.
After qualifying for the 2014 World Cup with two games to spare everything looked positive for Italy but doubts are creeping in after two poor displays mean they are set to miss out on a place among the top seeds in Brazil.
Photos from the football matches played in the Serie A, Bundesliga and French Ligue 1 on Sunday
Karim Benzema came off the bench to score 13 minutes from time and ruin any chance of a dream result for resilient Ludogorets as holders Real Madrid carved out a patchy 2-1 win in Wednesday's Champions League Group B match.
Bayern Munich put upstarts RB Leipzig firmly in their place by sweeping to an emphatic 3-0 home win, with all the goals coming in the first half, in a disappointingly one-sided top-of-the-table Bundesliga clash on Wednesday.
Juventus striker Gonzalo Higuain again showed his killer instinct with two expertly-taken goals in a late 3-1 win at Torino after their less illustrious neighbours had scored first and dominated the Serie A game on Sunday.
This and more from the happenings in the world of football
In case they needed it, the short trip to Crystal Palace will re-focus Chelsea's globe-trotting players on matters at home as the Premier League slips back into gear this weekend after the second international break of the season.
Juventus goalkeeper Gianluigi Buffon saved a penalty and Andrea Pirlo curled in a trademark free kick late in the game to give the Serie A leaders a dramatic 1-0 win at Genoa on Sunday.
Barcelona and Atletico Madrid led a Spanish Armada into the Champions League last 16 with home wins on Wednesday and in-form Aaron Ramsey steadied Arsenal's boat with a battling win against rocky Borussia Dortmund.
West Ham United maintained their impressive start to the season when they beat champions Manchester City 2-1 at Upton Park on Saturday to consolidate their place in the top four of the Premier League.
Chelsea face the prospect of having veteran Didier Drogba as their only fit striker for their visit to Manchester United on Sunday in what is usually one of the standout matches of the Premier League season.
Liverpool target Chelsea after midweek tinkering, while third-placed Manchester City, whose hopes of qualifying for the Champions League knockout stage were dealt a severe blow in a humiliating 2-1 home defeat by CSKA Moscow on Wednesday, travel south to face struggling Queens Park Rangers.
Chelsea reached the Champions League knock-out stage on Tuesday despite a 1-0 defeat by Basel in Group E after a late Mohamed Salah goal shocked the 2012 title winners, with Jose Mourinho saying they deserved to lose. Barcelona, without Lionel Messi but already into the last 16, went two goals down in Amsterdam but looked a different side in the second half after Ajax's Joel Veltman was sent off.
News of all that's transpired on and off the football field
For Manchester United, the answer to a slump in form or a crisis of confidence comes in 50 pound notes. Millions of them.
Dejan Lovern talks about his ambition to become a Liverpool legend at Anfield and why victory in the Merseyside derby against Everton could propel Reds' chances this season.
Cristiano Ronaldo renewed his personal battle with Lionel Messi by scoring his 71st Champions League goal, putting him three behind the Argentine's newly-set record, in Real Madrid's 1-0 win at FC Basel on Wednesday.
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