The three Premier League and three La Liga clubs in the last eight avoided each other, with Manchester City up against Atletico Madrid and Liverpool to face Portuguese side Benfica.
Aymeric Laporte's late header sealed a deserved 1-0 victory over Tottenham Hotspur
Manchester won the English Premier League, the English League Cup and FA Cup this season
Should Manchester United win their next two games, the gap will be cut to four points and while only a collapse of astonishing proportions would deny Manchester City the title.
Images from Saturday's action in the Premier League.
Manchester City reached their fourth straight League Cup final as second-half goals from John Stones and Fernandinho gave Pep Guardiola's side a 2-0 win over Manchester United in Wednesday's semi-final at Old Trafford.
The winner will be named on August 26, along with UEFA's women's player of the year and Champions League positional award winners, at the Champions League group stage draw in Istanbul.
Although Spurs always looked more comfortable on the ball it was Sean Dyche's side, who have just a point from their opening five games, who had come the closest.
Manchester City's quadruple bid remained intact as Ilkay Gundogan and Kevin de Bruyne secured a 2-0 win at Everton in their FA Cup quarter-final clash
A summary of Saturday's matches in the Premier League.
Chelsea beat Manchester City 1-0 on Saturday to book a place in next month's FA Cup final, thanks to a second-half goal by Hakim Ziyech which ended City manager Pep Guardiola's dream of steering his side to an unprecedented quadruple of titles.
News of all that's transpired on and off the football field
Guardiola gave a debut to close-season signing Nathan Ake, the Dutch defender signed from Bournemouth, lining up alongside John Stones in the centre of defence.
Before the game, a few protesters handed out fliers outside the stadium where Man City played local outfit Kitchee.
News of all that transpired on and off the football field
German international Ilkay Gundogan scored twice and was at the heart of City's hugely impressive display as Pep Guardiola's side delivered the kind of football that took them to title wins in 2018 and 2019.
News of all that's transpired on and off the football field.
The 29-year-old missed the last three ManchesterCity games and both of Argentina's World Cup qualifiers earlier this month following his road traffic accident in the Netherlands.
Liam Delap, the son of former Stoke City defender Rory, scored the opener for Pep Guardiola's side in the 2-1 win at the Etihad Stadium
Liverpool manager Juergen Klopp is expecting his toughest test yet in a Merseyside derby when his side face local rivals Everton in the Premier League on Sunday.
Images from the English Premier League matches played on Wednesday night.
City's Guardiola defends Mendy after COVID protocol breach.
Real are on 81 points with four games to go. They are 17 points ahead of nearest rivals Sevilla.
Images from the English Premier League matches played on Wednesday night.
Arteta, who will lead City in their Champions League opener against Olympique Lyonnais on Wednesday because manager Pep Guardiola is suspended, also said that his team were better placed to challenge for top European honours this season.
Manchester City took a major step towards retaining their Premier League title with a 1-0 win over second-placed Chelsea on Saturday, opening up a 13-point lead at the top of the table for Pep Guardiola's side.
Manchester City marched into the quarter-finals of the Champions League
Sergio Aguero believes the 14-point gap between the defending champions and Premier League leaders Liverpool is 'too hard' to overturn
France winger Franck Ribery is highly unlikely to recover from an ankle injury in time to feature for Bayern Munich in the Champions League fixture against Porto, coach Pep Guardiola said on the eve of the match on Monday.
Champions Manchester City have won their last 10 home league matches scoring a total of 36 goals.
Kevin de Bruyne's first-half penalty and a superb strike by Raheem Sterling after the break earned holders Manchester City a comfortable 2-0 away win at Newcastle United in the weekend's last FA Cup quarter-final on Sunday.
Rediff.com brings a preview of the main matches coming up this weekend in the English Premier League.
News of all that's transpired on and off the football field
Manchester City manager Pep Guardiola has been named the Premier League manager of the month for February, while in-form Tottenham Hotspur striker Harry Kane picked up his fourth player of the month award.
Manchester City crushed Leeds United 7-0 at the Etihad Stadium on Tuesday to make it seven Premier League wins a row and move four points clear at the top of the table.
Guardiola said City had plenty of options, with Gabriel Jesus the only main striker fit and ready but Ilkay Gundogan and Raheem Sterling are able to slot into the role.
Manchester United manager Jose Mourinho will not stoke his rivalry with fellow new recruit Pep Guardiola at Manchester City next season because it could damage his team's Premier League title hopes.
It was not so much the maths, though Liverpool's nine-point advantage over defending champions City, with one point less over Leicester City and Chelsea, is a significant gap, especially as Juergen Klopp's side have lost one league game in 18 months.
Sterling has scored six goals in five starts for City this season and has impressed with his overall contribution to Guardiola's prolific attack which has struck 29 goals in eight Premier League games.