Lionel Messi, who is Barcelona's all-time top scorer with 634 goals in 731 games, is expected to spend three seasons at Manchester City before moving to CFG's Major League Soccer franchise New York City FC.
It will be a poignant evening, with both games -- City vs Arsenal and Aston Villa vs Sheffield United -- played inside empty stadiums and marked before kickoff by a minute's silence for the more than 40,000 people to die of the virus in the UK.
Barcelona hammered Real Valladolid 4-0 at home on Sunday to retain their La Liga crown and brushed aside any doubts that they were about to be usurped by Real Madrid as the top club in Spain.
Manchester City said in a statement that both players did not display any symptoms and are currently self-isolating in line with protocols established by the Premier League and the British government.
Aguero will not start against Man United: Guardiola.
Arsenal's defence of the trophy ended with something of a whimper as Mikel Arteta's side struggled with repeatedly sloppy defending.
The perfectionist in Pep Guardiola forbids him to get remotely carried away by Manchester City's 100 per cent record this season even though they made it 10 wins out of 10 under their new Spanish manager on Saturday.
PSG went ahead in the first half, but Mauricio Pochettino's side lost control after the break
Manchester City must rebuild for title challenge: Guardiola
"Barcelona and Sergio Busquets signed this morning an agreement to renew the player's contract, which will end on June 30 2023," Barca said in a statement.
The three Premier League and three La Liga clubs in the last eight avoided each other, with Manchester City up against Atletico Madrid and Liverpool to face Portuguese side Benfica.
Arsenal must trust in Arteta, says Guardiola.
City, storming towards their third league title in four years, scored three late goals to wrap up victory and move onto 65 points with 11 games left to play ahead of Manchester United on 50 points with a game in hand.
'I always said I wanted to play abroad but the only thing that would stop me was if I was winning and successful on home shores. I was lucky I found a great club at Manchester United it would've been almost impossible for me to leave'
All the action that transpired on and off the football field
Thousands of Manchester City fans lined the streets as the English Premier League champions celebrated with open-top bus parade.
Trippier suspension temporarily halted by FIFA
City winger Riyad Mahrez and defender Aymeric Laporte previously tested positive for the novel coronavirus earlier this month.
'By giving cameras unimpeded access to their world-class training facilities and coaches, and by showing off Guardiola's genius, All Or Nothing is a striking show of power, a declaration of their conviction of being the bigger club in Manchester,' says Dhruv Munjal.
Aymeric Laporte's late header sealed a deserved 1-0 victory over Tottenham Hotspur
Liverpool boss Juergen Klopp has beaten Manchester United only twice in his career and never at Old Trafford -- his worst record against any Premier League side.
Should Manchester United win their next two games, the gap will be cut to four points and while only a collapse of astonishing proportions would deny Manchester City the title.
The winner will be named on August 26, along with UEFA's women's player of the year and Champions League positional award winners, at the Champions League group stage draw in Istanbul.
Images from the English Premier League matches played on Wednesday night.
Images from Saturday's action in the Premier League.
Chelsea beat Manchester City 1-0 on Saturday to book a place in next month's FA Cup final, thanks to a second-half goal by Hakim Ziyech which ended City manager Pep Guardiola's dream of steering his side to an unprecedented quadruple of titles.
Manchester City's quadruple bid remained intact as Ilkay Gundogan and Kevin de Bruyne secured a 2-0 win at Everton in their FA Cup quarter-final clash
A clash between supposedly the two most expensive lineups in history overseen by two of the most decorated coaches will end the phoney war and ignite the Premier League season for real when Manchester United host Manchester City on Saturday.
Manchester City reached their fourth straight League Cup final as second-half goals from John Stones and Fernandinho gave Pep Guardiola's side a 2-0 win over Manchester United in Wednesday's semi-final at Old Trafford.
Real are on 81 points with four games to go. They are 17 points ahead of nearest rivals Sevilla.
A summary of Saturday's matches in the Premier League.
Although Spurs always looked more comfortable on the ball it was Sean Dyche's side, who have just a point from their opening five games, who had come the closest.
Pizzas are off the menu for Manchester City players as manager Pep Guardiola has imposed strict weight parameters on the squad breaching which will result in training bans, left back Gael Clichy has said.
Guardiola gave a debut to close-season signing Nathan Ake, the Dutch defender signed from Bournemouth, lining up alongside John Stones in the centre of defence.
Images from the English Premier League matches played on Wednesday night.
German international Ilkay Gundogan scored twice and was at the heart of City's hugely impressive display as Pep Guardiola's side delivered the kind of football that took them to title wins in 2018 and 2019.
Manchester won the English Premier League, the English League Cup and FA Cup this season
News of all that's transpired on and off the football field.
News of all that transpired on and off the football field