Seven-time champion Williams had been bidding to claim a record-equalling 24th Grand Slam crown but made too many errors as Kerber ran out a comfortable winner in the final.
The exodus of seeded players has been so spectacular that only one of the top 10 remains -- number seven Karolina Pliskova.
Serena Williams likened the frustration she felt in Tuesday's shock defeat by Maria Sakkari at the Western and Southern Open to that of being stuck in a bad relationship.
Serena Williams had been a vulnerable conqueror at this year's majors, living dangerously and dicing with defeat on numerous occasions as she tried to become only the fourth woman to complete the calendar Grand Slam.
Meet the celebs who wowed at New York's biggest fashion gala of the year.
Serena Williams fuelled talk of a dream-team partnership with home favourite Andy Murray after declaring her availability for the Wimbledon mixed doubles.
American tennis star Serena Williams rose early on Saturday to get ready for her friend Meghan Markle's wedding to Britain's Prince Harry with a gold face treatment mask and personal make-up artist.
Daniil Medvedev and Karen Khachanov crushed second seed Dominic Thiem and third seed Alexander Zverev respectively to set up an all-Russian semi-final at the Rogers Cup in Montreal on Friday.
Tennis star Serena Williams says she is concerned about the Zika outbreak ahead of August's Rio Olympics, but has faith in the support team dealing with worries about the mosquito-carried virus.
Serena Williams became just the fourth player ever to win a particular tournament at least seven times when she triumphed in the Sony Open last week. Here's a look at three players who preceded the American to the feat.
Serena Williams clinched a record 23rd grand slam title at the Australian Open on Saturday but spent most of the immediate aftermath talking about her older sister Venus.
US Open champion Naomi Osaka grew up dreaming of competing against Serena Williams in a Grand Slam final but never would have dared to go as far as to think her idol would be reduced to tears in a drama-filled match.
The fourth-seeded Belgian will meet compatriot Kim Clijsters in the women's French Open final.
It will be the 22nd career match-up between the two long-time rivals, who somehow have avoided each other at the US Open throughout their long careers.
The world No. 1 was beaten by Justine Henin-Hardenne in the final of the Family Circle Cup.
Serena Williams is skipping practice on the eve of the French Open final as the World No 1 battles with illness, organisers said on Friday.
McEnroe had claimed that Serena, who is the best player of her gender, would be ranked 700 if she plays on the men's circuit.
Twenty-three time grand slam champion Serena Williams will play her first match since the birth of her daughter when she faces off against French Open winner Jelena Ostapenko at the Mubadala World Tennis Championship in Abu Dhabi next week.
Serena Williams has clicked into gear so quickly on her Wimbledon return it is hard to believe she has played only a handful of matches
Germany's experienced Angelique Kerber stands in the way of the 36-year-old American and an eighth, and arguably most impressive, All England Club singles crown which would see her match Margaret Court's all-time record of 24 Grand Slam titles.
The duo hailed each other in the post-match interview before the tennis titans captured the iconic moment in what Hopman Cup on Twitter described as the 'greatest selfie of all time'.
Once a simmering volcano of emotions that could erupt at any moment, Australian Open champion Serena Williams appears to be heading down a path that may perhaps lead to her being renamed Serene.
Halep has struggled for form and fitness since her first-round defeat at the US Open last August and came to Australia on a five-match losing streak and without a coach after long-serving Darren Cahill left for "family reasons".
Naomi Osaka faces a far more daunting task: Playing against her hero in the US Open final.
Steamrolls Dutch Rus to proceed to Round 2
The World No 1 Serena was joined by Hollywood actress Eva Longoria at a Champ'Seed party in Monaco.
Serena Williams plans to play fewer tournaments in the future to aid her quest to win more Grand Slam titles, according to her coach Patrick Mouratoglou.
The 28-year-old said beating American great Williams was the finest win of her career, outstripping her upset of world number one Ash Barty at last year's US Open.
Tennis player Serena Williams was recently spotted getting cozy with rapper Drake at a fancy downtown restaurant in Ohio.
Serena Williams is chasing Australian Margaret Court's record 24 Grand Slam singles titles
Former world number one Serena Williams has pulled out of the French Open because she has not fully recovered from health issues, organisers said on Thursday.
Holder Serena Williams beat Justine Henin 6-2, 6-0 to reach the semi-finals of the Sony Ericsson Open.
Naomi Osaka defeated Serena Williams 6-2, 6-4 in a dramatic women's singles final at the US Open to claim her first career Grand Slam title on Saturday.
US Open: Serena ready for Svitolina challenge
Tennis great Serena Williams on Wednesday said she would consider coaching after calling it quits.
Serena Williams recently faced a social media criticism after she posted a photoshopped picture of herself.
Serena Williams was forced to go on the attack once again to defend equal prize money after she reached a ninth Wimbledon final in a new record time. The world number one blasted Russia's Elena Vesnina off Centre Court in just 48mins 34sec, the fastest ever semi-final at the All England Club. Vesnina earned 500,000 ($649,000) by making the last four.
On the men's side, the fields have already been divided into two ATP 250 tournaments.
The new Da da ding Nike ad, featuring actor Deepika Padukone, has gone viral. It has been appreciated by most but panned by some, and despite the mixed reviews it has nearly crashed the internet.
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