Chelsea manager Jose Mourinho was fuming after his team were denied what he described as a 'Big Ben' penalty.
A 3-0 reality check at the hands of Manchester City was always a moment waiting to happen for Southampton. Just how they bounce back from Sunday's defeat may now determine their fortunes this season.
With Premier League leaders Chelsea on top form, Manchester City will be hoping their Champions League win over Bayern Munich boosts confidence and re-ignites their title defence when they visit high-flying Southampton on Sunday (1900 IST) .
Chelsea's early season slump turned into a full-blown crisis on Saturday when they were beaten 3-1 by Southampton while Manchester City went top of the Premier League with Sergio Aguero scoring five in a 6-1 win over Newcastle United.
Leicester City failed to grasp their first chance to clinch the Premier League title when they drew 1-1 at Manchester United on Sunday but they moved ever closer to a first English top-flight crown.
A summary of Thursday's matches in Europe's second tier club football tournament
Roma teenager Afena-Gyan plays down apparent racist remark.
Antonio Valencia's early thunderbolt put Manchester United en route to a 4-0 Premier League victory over Everton on Sunday, but they needed a flurry of late goals to finally subdue their unfortunate visitors.
Lionel Messi was at the top of his game as Barcelona earned a 3-2 win at Athletic Bilbao on Wednesday to move up to third in La Liga.
Images from football action around European leagues played on Sunday
'Everton can confirm that Wayne Rooney has rejoined the club from Manchester United on a two-year deal for an undisclosed fee'
Barcelona continued their rampant run of domestic form to beat Osasuna 2-0 away from home on Saturday and move to within two points of La Liga leaders Atletico Madrid, with Lionel Messi setting up goals scored by Jordi Alba and teenager Ilaix Moriba.
While Chelsea and Manchester City slug it out at the top of the Premier League, Louis van Gaal's Old Trafford revolution gathers ever more momentum in the red half of Manchester.
A summary of Wednesday night's action in the UEFA Champions League.
Lionel Messi scored a 50th freekick goal for Barcelona as he led his side to a quick-fire comeback to win 3-2 at Valencia on Sunday and keep the pressure on La Liga title rivals Atletico Madrid and Real Madrid.
Czechs beat Slovaks 1-0 to ensure Nations League B survival
Manchester United manager Jose Mourinho has dismissed suggestions that midfielder Paul Pogba faces a lengthy lay-off because of a hamstring injury sustained in the Champions League defeat of Basel on Tuesday.
Following is a match by match look at the English Premier League's weekend fixtures:
Louis Van Gaal said it would take him three years to transform Manchester United into a potential title-winning team when he became manager last summer, but judged by Sunday's loss to Southampton, he might have to wait a lot longer than that.
News of all that's transpired on and off the football field
Images from the EPL match played between Manchester United and Southampton on Monday.
City salvage draw at home with Sterling's superb late volley after Rooney put Everton ahead. Rooney scored his second goal in as many games this season. The strike was his 200th in the Premier League, making him just the second player after former England forward Alan Shearer to reach that milestone.
Following is a match by match look at the English Premier League's weekend fixtures:
Images from the UEFA Champions League matches played on Tuesday night.
Angel Correa saw La Liga leaders Atletico Madrid snatch a 2-1 victory away to Granada on Saturday
Manchester United are optimistic ahead of a crucial period of fixtures as they are close to finding their best form, midfielder Ander Herrera said ahead of Sunday's top of the table showdown against Premier League leaders Manchester City.
News of all that's transpired on and off the football field.
Ashley Williams powered home a towering header in the 86th minute as Everton fought back to claim a 2-1 win over Arsenal as the title hopefuls blew the chance to return to the Premier League summit.
News of all that's transpired on and off the football field.
Barcelona's fourth defeat of the season left them seventh in the standings on 14 points after 10 games, 12 points behind leaders Atletico.
Lionel Messi scored a penalty for the third Champions League game in a row with the Spaniards maintaining their winning start to the group stage.
Images from the UEFA Champions League matches played on Tuesday night.
A last-gasp Christian Benteke penalty handed Tim Sherwood his first win as Aston Villa manager.
Wayne Rooney's Everton homecoming ended in a 1-0 win over Slovak side Ruzomberok with the former Manchester United striker having a quiet return to Goodison Park in the Europa League, third qualifying round, first-leg on Thursday.
Champions Manchester City galvanised their pursuit of Premier League leaders Chelsea on Sunday with an emphatic 3-0 victory over a Southampton side who have surprisingly come between the leading title protagonists.
Manchester United manager Jose Mourinho was sent off for the second time in a month on Sunday as the controversial coach watched his side draw 1-1 at home to West Ham United and lose more ground in the English Premier League title race.
A stoppage-time goal from Miranda gave Brazil a 1-0 win over South American rivals Argentina in a foul-strewn friendly, while Netherlands secured a 1-1 draw at neighbours Belgium.
News of all that's transpired on and off the football field.
West Ham United capitalised on two mistakes from Arsenal's new goalkeeper Petr Cech to claim a surprise 2-0 victory at the Emirates and bring the Gunners' early Premier League optimism down to earth with a bump on Sunday.