While Africa, Asia and North America will not be represented, dashing any hope of a revolutionary breakthrough in the eventual destination of the trophy, at least one of this year's finalists will not have reached the title decider for half a century, if at all.
Manchester United climbed two places up to second in the Premier League after Marcus Rashford scored deep into stoppage time to give them a fortuitous 1-0 home win over Wolverhampton Wanderers on Tuesday.
Uruguay sealed their spot at the 2014 World Cup finals after a goalless draw at home to Jordan in the second leg of their intercontinental playoff on Wednesday saw them advance 5-0 on aggregate.
Radamel Falcao answered Zlatan Ibrahimovic's early opening goal for Paris St Germain with a quick equaliser for a 1-1 draw that kept Monaco top of Ligue 1 on Sunday.
Second half goals from Presnel Kimpembe and Kylian Mbappe gave the impressive French side a clear advantage ahead of the return in Paris on March 6.
Robert Lewandowski struck twice in the first half as holders Bayern Munich cruised past Schalke 04 3-0 on Wednesday to reach the German Cup semi-finals.
Milan replaced Gennaro Gattuso with former Sampdoria coach Giampaolo during the close season in a bid to improve on last season's fifth place and to take them back to the Champions League.
News of all that's transpired on and off the football field
News of all that's transpired on and off the football field
Uruguay crushed Ecuador 4-0 in their Copa America opener on Sunday with help from an early sending off that deflated their opponents and assured the 15-times champions the simplest of starts to their campaign.
News of all that's transpired on and off the football field
Eden Hazard finally scored his first goal for Real Madrid as his side beat second-placed Granada 4-2 in a highly entertaining game at the Santiago Bernabeu on Saturday to go four points clear at the top of La Liga.
Paraguay drew 1-1 with Uruguay at the Copa America to go top of Group B, one point ahead of Argentina before the tournament favourites take on eliminated Jamaica later on Saturday.
A summary of Wednesday's matches in the UEFA Champions League.
Images from the Champions League matches played on Tuesday
News of all that's transpired on and off the football field
Cristiano Ronaldo scored the 750th goal of his remarkable career in a 3-0 win over Dynamo Kyiv on Wednesday
News of all that's transpired on and off the football field
News of all that's transpired on and off the football field
Paris St Germain's Zlatan Ibrahimovic scored his first Ligue 1 goal this season before missing a penalty as they beat En Avant Guingamp 3-0 to extend their lead to four points on Tuesday.
Five-times European champions Barca, with their trident of Lionel Messi, Luis Suarez and Neymar subdued, have not exited in the last 16 since going out to Liverpool in the 2006/07 season and the score equalled their worst Champions league loss.
News of all that's transpired on and off the football field
Barcelona look well set to wrap up the La Liga title.
News of all that's transpired on and off the football field
A much-changed Real Madrid ground out a 2-0 victory at third-tier Fuenlabrada in their King's Cup last-32 first leg on Thursday, needing two dubious penalties to break down their stubborn hosts as both sides finished with 10 men.
Barcelona battled back from a goal down and scored twice in the second half to overcome hosts Borussia Moenchengladbach 2-1 in their Champions League Group C match on Wednesday despite the absence of the injured Lionel Messi.
News of all that's transpired on and off the football field
Juventus progressed to the Champions League last 16 after a Cristiano Ronaldo goal and a late header from substitute Alvaro Morata gave them a comeback 2-1 home win over Hungarians Ferencvaros on Tuesday.
World champion Marc Marquez underlined his dominance of MotoGP when he swept to a record-equalling 12th pole position of the season on a good day for Spain at the Australian Grand Prix on Saturday.
Ruthless Bayern Munich scored five goals in the first 35 minutes on the way to a 7-1 demolition of AS Roma on Tuesday which bore an uncanny resemblance to Germany's win over Brazil by the same score in the World Cup semi-final.
Brazil midfielder Casemiro stretched Real's advantage right before halftime with a gut-busting run to meet a cross from compatriot Vinicius, but Levante hit back shortly after the interval through former Madrid forward Borja Mayoral.
News of all that's transpired on and off the football field
News of all that's transpired on and off the football field
Mbappe struck in the 74th minute to put PSG on 80 points from 29 games and on the brink of retaining the title with second-placed Lille, who beat Nantes 3-2 away earlier on Sunday, still 20 points behind having played a game more.
RB Leipzig continued their remarkable first season in the Bundesliga when they brushed aside Mainz 05 3-1, their fifth win in a row, to go level on points with leaders Bayern Munich on Sunday.
Thomas Meunier volleyed a spectacular last-minute goal to give Paris St Germain a 2-1 win at FC Basel, which took them into the last 16 of the Champions League on Tuesday.
News of all that's transpired on and off the football field
A summary of Saturday's action in Ligue 1, La Liga and Serie A.
News of all that's transpired on and off the football field
Following this stunning turn-around of fortunes for Barcelona, here is a flashback of some of the best come-from-behind wins recorded in Europe's premier club competition.
